Search Results - "Kulkarni, Rahul V"

Transcriptional Bursting in Gene Expression: Analytical Results for General Stochastic Models by Kumar, Niraj, Singh, Abhyudai, Kulkarni, Rahul V

“…Gene expression in individual cells is highly variable and sporadic, often resulting in the synthesis of mRNAs and proteins in bursts. Such bursting has…”
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Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN by Morris, Elizabeth R., Hall, Gareth, Li, Chan, Heeb, Stephan, Kulkarni, Rahul V., Lovelock, Laura, Silistre, Hazel, Messina, Marco, Cámara, Miguel, Emsley, Jonas, Williams, Paul, Searle, Mark S.

“…In bacteria, the highly conserved RsmA/CsrA family of RNA-binding proteins functions as global posttranscriptional regulators acting on mRNA translation and…”
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The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae by Lenz, Derrick H, Mok, Kenny C, Lilley, Brendan N, Kulkarni, Rahul V, Wingreen, Ned S, Bassler, Bonnie L

“…Quorum-sensing bacteria communicate with extracellular signal molecules called autoinducers. This process allows community-wide synchronization of gene…”
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Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach by Zarringhalam, Kourosh, Tay, Yvonne, Kulkarni, Prajna, Bester, Assaf C., Pandolfi, Pier Paolo, Kulkarni, Rahul V.

“…Regulation by microRNAs (miRNAs) and modulation of miRNA activity are critical components of diverse cellular processes. Recent research has shown that…”
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Queueing Up for Translation by Kulkarni, Rahul V.

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CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae by Lenz, Derrick H., Miller, Melissa B., Zhu, Jun, Kulkarni, Rahul V., Bassler, Bonnie L.

“…Summary Bacteria communicate using a process called quorum sensing which involves production, secretion and detection of signalling molecules called…”
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Exact distributions for stochastic gene expression models with bursting and feedback by Kumar, Niraj, Platini, Thierry, Kulkarni, Rahul V

“…Stochasticity in gene expression can give rise to fluctuations in protein levels and lead to phenotypic variation across a population of genetically identical…”
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Neurosyphilis, A true chameleon of neurology by Pujari, Shripad, Kulkarni, Rahul, Duberkar, Dhananjay, Nirhale, Satish, Nadgir, Dattatraya, Dhonde, Pramod, Sakale, Tejas, Shembalkar, Prafulla, Meshram, Chandrashekhar

“…Background: Neurosyphilis (NS) is a rarely encountered scenario today. Manifestations are heterogeneous, and their characteristics have changed in the…”
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Myelin Oligodendrocyte Glycoprotein (MOG)-IgG associated demyelinating disease: Our experience with this distinct syndrome by Pujari, Shripad, Kulkarni, Rahul, Nadgir, Dattatraya, Ojha, Pawan, Nagendra, Shashank, Aglave, Vikram, Nadgir, Rashmi, Sant, Hemant, Palasdeokar, Nilesh, Nirhale, Satish, Bandishti, Sunil

“…Background: Discovery of serum myelin oligodendrocyte glycoprotein (MOG) antibody testing in demyelination segregated MOG-IgG disease from AQ-4-IgG positive…”
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Intrinsic noise in stochastic models of gene expression with molecular memory and bursting by Jia, Tao, Kulkarni, Rahul V

“…Regulation of intrinsic noise in gene expression is essential for many cellular functions. Correspondingly, there is considerable interest in understanding how…”
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Direct Regulation by the Vibrio cholerae Regulator ToxT To Modulate Colonization and Anticolonization Pilus Expression by Hsiao, Ansel, Xu, Xiao, Kan, Biao, Kulkarni, Rahul V, Zhu, Jun

“…The pathogen Vibrio cholerae uses a large number of coordinated transcriptional regulatory events to transition from its environmental reservoir to the host…”
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Constraining the complexity of promoter dynamics using fluctuations in gene expression by Kumar, Niraj, Kulkarni, Rahul V

“…Gene expression is an inherently stochastic process with transcription of mRNAs often occurring in bursts: short periods of activity followed by typically…”
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Stochastic Modeling of Gene Regulation by Noncoding Small RNAs in the Strong Interaction Limit by Kumar, Niraj, Zarringhalam, Kourosh, Kulkarni, Rahul V.

“…Noncoding small RNAs (sRNAs) are known to play a key role in regulating diverse cellular processes, and their dysregulation is linked to various diseases such…”
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Exact protein distributions for stochastic models of gene expression using partitioning of Poisson processes by Pendar, Hodjat, Platini, Thierry, Kulkarni, Rahul V

“…Stochasticity in gene expression gives rise to fluctuations in protein levels across a population of genetically identical cells. Such fluctuations can lead to…”
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Acute haemorrhagic leukoencephalitis (AHLE) – our experience and a short review by Pujari, Shripad S., Kulkarni, Rahul V., Ojha, Pawan, Gursahani, Roop, Nadgir, Dattatraya, Patil, Sarika, Soni, Girish, Bangar, Sachin, Harshe, Amol, Mandolkar, Mahesh, Joshi, Aniruddha, Kadam, Sagar, Goyal, Aditi

“…Acute haemorrhagic leukoencephalitis (AHLE), a rare variant of acute disseminated encephalomyelitis (ADEM), often presents differently from classical ADEM,…”
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Stochastic modeling of phenotypic switching and chemoresistance in cancer cell populations by Kumar, Niraj, Cramer, Gwendolyn M., Dahaj, Seyed Alireza Zamani, Sundaram, Bala, Celli, Jonathan P., Kulkarni, Rahul V.

“…Phenotypic heterogeneity in cancer cells is widely observed and is often linked to drug resistance. In several cases, such heterogeneity in drug sensitivity of…”
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Stochastic gene expression conditioned on large deviations by Horowitz, Jordan M, Kulkarni, Rahul V

“…The intrinsic stochasticity of gene expression can give rise to large fluctuations and rare events that drive phenotypic variation in a population of…”
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Bioinformatic Approach for Prediction of CsrA/RsmA-Regulating Small RNAs in Bacteria by Fakhry, Carl T, Zarringhalam, Kourosh, Kulkarni, Rahul V

“…CsrA/RsmA is a RNA-binding protein that functions as a global regulator controlling important processes such as virulence, secondary metabolism, motility, and…”
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Entropy regularized reinforcement learning using large deviation theory by Arriojas, Argenis, Adamczyk, Jacob, Tiomkin, Stas, Kulkarni, Rahul V.

“…Reinforcement learning (RL) is an important field of research in machine learning that is increasingly being applied to complex optimization problems in…”
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Post-transcriptional regulation of noise in protein distributions during gene expression by Jia, Tao, Kulkarni, Rahul V

“…The intrinsic stochasticity of gene expression can lead to a large variability of protein levels across a population of cells. Variability (or noise) in…”
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