Search Results - "Kulkarni, Paresh P."

Mitochondrial ATP generation in stimulated platelets is essential for granule secretion but dispensable for aggregation and procoagulant activity by Kulkarni, Paresh P, Ekhlak, Mohammad, Sonkar, Vijay K, Dash, Debabrata

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D-dimer, disease severity, and deaths (3D-study) in patients with COVID-19: a systematic review and meta-analysis of 100 studies by Varikasuvu, Seshadri Reddy, Varshney, Saurabh, Dutt, Naveen, Munikumar, Manne, Asfahan, Shahir, Kulkarni, Paresh P., Gupta, Pratima

“…Hypercoagulability and the need for prioritizing coagulation markers for prognostic abilities have been highlighted in COVID-19. We aimed to quantify the…”
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Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents by Kulkarni, Paresh P, Tiwari, Arundhati, Singh, Nitesh, Gautam, Deepa, Sonkar, Vijay K, Agarwal, Vikas, Dash, Debabrata

“…Platelets are critical to arterial thrombosis, which underlies myocardial infarction and stroke. Activated platelets, regardless of the nature of their…”
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Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation by Kulkarni, Paresh P, Ekhlak, Mohammad, Dash, Debabrata

“…Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express…”
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Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4 by Prakash, Prem, Kulkarni, Paresh P., Lentz, Steven R., Chauhan, Anil K.

“…Cellular fibronectin containing extra domain A (Fn-EDA+), which is produced in response to tissue injury in several disease states, has prothrombotic activity…”
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Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release by Chaurasia, Susheel N, Kushwaha, Geeta, Kulkarni, Paresh P, Mallick, Ram L, Latheef, Nazmy A, Mishra, Jai K, Dash, Debabrata

“…Oxygen-compromised environments, such as high altitude, are associated with platelet hyperactivity. Platelets confined within the relatively impervious core of…”
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Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice by Prakash, Prem, Kulkarni, Paresh P., Chauhan, Anil K.

“…Thrombospondin 1 (TSP1) has been suggested as a counter receptor to platelet glycoprotein Ibα that supports initial platelet adhesion in absence of von…”
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Regulatory Role of Proteasome in Determination of Platelet Life Span by Nayak, Manasa K., Kulkarni, Paresh P., Dash, Debabrata

“…Limit of platelet life span (8–10 days) is determined by the activity of a putative “internal clock” composed of Bcl-2 family proteins, whereas the role of…”
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Editorial: COVID-19 and thrombo-inflammatory responses by Subramaniam, Saravanan, Reinhardt, Christoph, Kulkarni, Paresh P, Spiezia, Luca

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Correction to: Plasma Fibrinogen Is a Natural Deterrent to Amyloid β-Induced Platelet Activation and Neuronal Toxicity by Sonkar, Vijay K, Kulkarni, Paresh P, Chaurasia, Susheel N, Dash, Ayusman, Jauhari, Abhishek, Parmar, Devendra, Yadav, Sanjay, Dash, Debabrata

“…Following publication of the original article [1], the author reported an error in Figure 1. The correct version of Figure 1 is as follows…”
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Plasma Fibrinogen Is a Natural Deterrent to Amyloid β-Induced Platelet Activation and Neuronal Toxicity by Sonkar, Vijay K, Kulkarni, Paresh P, Chaurasia, Susheel N, Dash, Ayusman, Jauhari, Abhishek, Parmar, Devendra, Yadav, Sanjay, Dash, Debabrata

“…Alzheimer’s disease (AD) is a devastating neurodegenerative disorder, characterized by extensive loss of neurons and deposition of amyloid β (Aβ) in the form…”
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Energy metabolism in platelets fuels thrombus formation: Halting the thrombosis engine with small-molecule modulators of platelet metabolism by Kulkarni, Paresh P., Ekhlak, Mohammad, Dash, Debabrata

“…Platelets are circulating cells central to haemostasis that follows vessel injury, as well as thrombosis that ensues as a consequence of pathological stasis or…”
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Fatty acid oxidation fuels agonist‐induced platelet activation and thrombus formation: Targeting β‐oxidation of fatty acids as an effective anti‐platelet strategy by Kulkarni, Paresh P., Ekhlak, Mohammad, Singh, Vipin, Kailashiya, Vikas, Singh, Nitesh, Dash, Debabrata

“…Platelet mitochondria possess remarkable plasticity for oxidation of energy substrates, where metabolic dependency on glucose or fatty acids is higher than…”
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Necroptosis executioner MLKL plays pivotal roles in agonist-induced platelet prothrombotic responses and lytic cell death in a temporal order by Ekhlak, Mohammad, Kulkarni, Paresh P., Singh, Vipin, Chaurasia, Susheel N., Mohapatra, Saroj Kant, Chaurasia, Rameshwar Nath, Dash, Debabrata

“…Necroptosis is a form of programmed cell death executed by receptor-interacting serine/threonine protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase…”
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Amine-Modified Graphene: Thrombo-Protective Safer Alternative to Graphene Oxide for Biomedical Applications by Singh, Sunil K, Singh, Manoj K, Kulkarni, Paresh P, Sonkar, Vijay K, Grácio, José J. A, Dash, Debabrata

“…Graphene and its derivatives have attracted significant research interest based on their application potential in different fields including biomedicine…”
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Amyloid β peptide stimulates platelet activation through RhoA‐dependent modulation of actomyosin organization by Sonkar, Vijay K., Kulkarni, Paresh P., Dash, Debabrata

“…Platelets contribute to 95% of circulating amyloid precursor protein in the body and have widely been employed as a “peripheral” model of neurons in…”
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Role of Thrombosis in Neurodegenerative Diseases: An Intricate Mechanism of Neurovascular Complications by Beura, Samir Kumar, Panigrahi, Abhishek Ramachandra, Yadav, Pooja, Kulkarni, Paresh P, Lakhanpal, Vikas, Singh, Bhupinder, Singh, Sunil Kumar

“…Thrombosis, the formation of blood clots in arteries or veins, poses a significant health risk by disrupting the blood flow. It can potentially lead to major…”
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AMPK inhibition protects against arterial thrombosis while sparing hemostasis through differential modulation of platelet responses by Kulkarni, Paresh P., Sonkar, Vijay K., Gautam, Deepa, Dash, Debabrata

“…AMP-activated protein kinase (AMPK) is a metabolic master switch that has critical role in wide range of pathologies including cardiovascular disorders. As…”
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Lysophosphatidylcholine induces oxidative stress and calcium‐mediated cell death in human blood platelets by Yadav, Pooja, Beura, Samir K., Panigrahi, Abhishek R., Kulkarni, Paresh P., Yadav, Mithlesh K., Munshi, Anjana, Singh, Sunil K.

“…Platelets are essential component of circulation that plays a major role in hemostasis and thrombosis. During activation and its demise, platelets release…”
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Nanogold-coated stent facilitated non-invasive photothermal ablation of stent thrombosis and restoration of blood flow by Singh, Nitesh, Kulkarni, Paresh P, Tripathi, Prashant, Agarwal, Vikas, Dash, Debabrata

“…In-stent restenosis (ISR) and stent thrombosis (ST) are the most serious complications of coronary angioplasty and stenting. Although the evolution of…”
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