Search Results - "Kuljis, Dika"

Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington's Disease by Kuljis, Dika A, Gad, Laura, Loh, Dawn H, MacDowell Kaswan, Zoë, Hitchcock, Olivia N, Ghiani, Cristina A, Colwell, Christopher S

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies…”
Get full text

Gonadal- and Sex-Chromosome-Dependent Sex Differences in the Circadian System by Kuljis, Dika A, Loh, Dawn H, Truong, Danny, Vosko, Andrew M, Ong, Margaret L, McClusky, Rebecca, Arnold, Arthur P, Colwell, Christopher S

“…Compelling reasons to study the role of sex in the circadian system include the higher rates of sleep disorders in women than in men and evidence that sex…”
Get full text

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease by Whittaker, Daniel S., Loh, Dawn H., Wang, Huei-Bin, Tahara, Yu, Kuljis, Dika, Cutler, Tamara, Ghiani, Cristina A., Shibata, Shigenobu, Block, Gene D., Colwell, Christopher S.

“…Huntington’s disease (HD) patients suffer from progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction…”
Get full text

Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons by Kuljis, Dika A, Micheva, Kristina D, Ray, Ajit, Wegner, Waja, Bowman, Ryan, Madison, Daniel V, Willig, Katrin I, Barth, Alison L

“…Gephyrin has long been thought of as a master regulator for inhibitory synapses, acting as a scaffold to organize γ-aminobutyric acid type A receptors (GABA…”
Get full text

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease by Kudo, Takashi, Schroeder, Analyne, Loh, Dawn H., Kuljis, Dika, Jordan, Maria C., Roos, Kenneth P., Colwell, Christopher S.

“…Many patients with Huntington's disease (HD) exhibit disturbances in their daily cycle of sleep and wake as part of their symptoms. These patients have…”
Get full text

Substrate Availability of Mutant SPT Alters Neuronal Branching and Growth Cone Dynamics in Dorsal Root Ganglia by Jun, Byung Kyu, Chandra, Ankush, Kuljis, Dika, Schmidt, Brian P, Eichler, Florian S

“…Serine palmitoyltransferase (SPT) is a key enzyme in the first step of sphingolipid biosynthesis. Mutations in the SPTLC1 gene that encodes for SPT subunits…”
Get full text

Fast delayed rectifier potassium current: critical for input and output of the circadian system by Kudo, Takashi, Loh, Dawn H, Kuljis, Dika, Constance, Cara, Colwell, Christopher S

“…The ability to generate intrinsic circadian rhythms in electrical activity appears to be a key property of central pacemaker neurons and one essential to the…”
Get full text

Tagging of Endogenous BK Channels with a Fluorogen-Activating Peptide Reveals β4-Mediated Control of Channel Clustering in Cerebellum by Pratt, Christopher P, Kuljis, Dika A, Homanics, Gregg E, He, Jianjun, Kolodieznyi, Dmytro, Dudem, Srikanth, Hollywood, Mark A, Barth, Alison L, Bruchez, Marcel P

“…BK channels are critical regulators of neuronal activity, controlling firing, neurotransmitter release, cerebellar function, and BK channel mutations have been…”
Get full text

Fluorescence-Based Quantitative Synapse Analysis for Cell Type-Specific Connectomics by Kuljis, Dika A, Park, Eunsol, Telmer, Cheryl A, Lee, Jiseok, Ackerman, Daniel S, Bruchez, Marcel P, Barth, Alison L

“…Anatomical methods for determining cell type-specific connectivity are essential to inspire and constrain our understanding of neural circuit function. We…”
Get full text

Role of vasoactive intestinal peptide in the light input to the circadian system by Vosko, Andrew, van Diepen, Hester C., Kuljis, Dika, Chiu, Andrew M., Heyer, Djai, Terra, Huub, Carpenter, Ellen, Michel, Stephan, Meijer, Johanna H., Colwell, Christopher S.

“…The neuropeptide vasoactive intestinal peptide (VIP) is expressed at high levels in a subset of neurons in the ventral region of the suprachiasmatic nucleus…”
Get full text

Overexpression of the Wild-Type SPT1 Subunit Lowers Desoxysphingolipid Levels and Rescues the Phenotype of HSAN1 by Eichler, Florian S, Hornemann, Thorsten, McCampbell, Alex, Kuljis, Dika, Penno, Anke, Vardeh, Daniel, Tamrazian, Eric, Garofalo, Kevin, Lee, Ho-Joon, Kini, Lohit, Selig, Martin, Frosch, Matthew, Gable, Ken, von Eckardstein, Arnold, Woolf, Clifford J, Guan, Guiman, Harmon, Jeffrey M, Dunn, Teresa M, Brown, Robert H., Jr

“…Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT) cause an adult-onset, hereditary sensory, and autonomic neuropathy type I (HSAN1). We…”
Get full text

Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington’s disease by Kuljis, Dika, Kudo, Takashi, Tahara, Yu, Ghiani, Cristina A., Colwell, Christopher S.

“…Disturbances in sleep/wake cycle are a common complaint of individuals with Huntington's disease (HD) and are displayed by HD mouse models. The underlying…”
Get full text

Circadian dysfunction in the Q175 model of Huntington's disease: Network analysis by Smarr, Benjamin, Cutler, Tamara, Loh, Dawn H., Kudo, Takashi, Kuljis, Dika, Kriegsfeld, Lance, Ghiani, Cristina A., Colwell, Christopher S.

“…Disturbances in sleep/wake cycle are a common complaint of individuals with Huntington's disease (HD) and are displayed by HD mouse models. The underlying…”
Get full text

Early developmental abnormalities in hippocampal synapse distribution in a mouse model of Alzheimer’s disease: Development of new models and analysis methods/novel assays and technologies by Ray, Ajit, Bernhard, Sarah M., Kuljis, Dika A., Bruchez, Marcel P., Barth, Alison L

Get full text

Early developmental abnormalities in hippocampal synapse distribution in a mouse model of Alzheimer’s disease by Ray, Ajit, Bernhard, Sarah M., Kuljis, Dika A., Bruchez, Marcel P., Barth, Alison L

“…Background Alzheimer’s disease (AD) has long been described as a disease arising from progressive loss of synapses and cell death. While this is certainly true…”
Get full text

Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: Insights from a transgenic mouse model by Willison, L. David, Kudo, Takashi, Loh, Dawn H., Kuljis, Dika, Colwell, Christopher S.

“…Sleep disorders are nearly ubiquitous among patients with Parkinson's disease (PD), and they manifest early in the disease process. While there are a number of…”
Get full text

Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: Insights from a transgenic mouse model: Circadian rhythms and sleep disorders by WILLISON, L. David, KUDO, Takashi, LOH, Dawn H, KULJIS, Dika, COLWELL, Christopher S

Get full text

Disrupted reproduction, estrous cycle, and circadian rhythms in female vasoactive intestinal peptide deficient mice by Loh, Dawn Hsiao-Wei, Kuljis, Dika Ana, Azuma, Lauren, Wu, Yingfei, Truong, Danny, Wang, Huei-Bin, Colwell, Christopher Scott

“…The female reproductive cycle is gated by the circadian timing system and may be vulnerable to disruptions in the circadian system. Prior work suggests that…”
Get full text

Ionic mechanisms of circadian disruption by Kuljis, Dika Ana

“…The temporal patterning of biological function is regulated by the circadian system on the cellular and systemic levels. In mammals, rhythmic neural output…”
Get full text

Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington's Disease: e0147583 by Kuljis, Dika A, Gad, Laura, Loh, Dawn H, Kaswan, Zoee MacDowell, Hitchcock, Olivia N, Ghiani, Cristina A, Colwell, Christopher S

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies…”
Get full text