Search Results - "Kulinich, T.  M."

Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells by Kulinich, T. M., Kiseleva, Ya. Yu, Shishkin, A. M., Kudinova, E. A., Knyazeva, O. B., Ranjit, R., Bozhenko, V. K., Solodky, V. A.

“…Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR)…”
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Analysis of Cell Response to Ultrahigh Dose-Rate Proton Irradiation by Akulinichev, S. V., Gavrilov, Yu. K., Glukhov, S. I., Ivanov, A. V., Kokontsev, D. A., Kulinich, T. M., Kuznetsova, E. A., Martynova, V. V., Yakovlev, I. A.

“…The biological effects of proton irradiation with high and ultrahigh dose rates (up to 0.3 MGy/s) of cultured human tumor and normal cells at the Bragg peak…”
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Analysis of the expression of matrix RNA of a panel of genes of morphologically unchanged rectal epithelium as a method of early diagnosis of colon pathology by Bozhenko, V.  C., Goncharov, S. V., Zakharenko, M. V., Kiseleva, Ya.  Yu. , Karmakova, T. A., Kulinich, T.  M., Stanoevich, U. S., Melnikova, N.  V., Senchukova, A. L., Grunin,  I.  B. , Bliznyukov, O.  P., Solodky, V. A.

“…Introduction . The absence of specific clinical symptoms in the early stages of colorectal cancer development leads to the fact that a quarter of patients who…”
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Study of the suppression of a tumor growth expressing a carcinoembryonic antigen with a new high-tech drug carplasmin (CAR-T therapy) in Balb/c nude mice by Bozhenko, V. K., Shishkin, A. M., Shkoporov, A. N., Kiseleva, Y. Yu, Kulinich, T. M., Bolshakova, O. B., Kudinova, E. A., Solodkiy, V. A.

“…Introduction. Adoptive immunotherapy based on chimeric antigen receptors (CAR) is considered as a promising direction in the treatment of solid malignant…”
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Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells by Bozhenko, V. K., Ivanov, A. V., Kulinich, T. M., Smirnov, V. P., Shishkin, A. M., Solodky, V. A.

“…We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic…”
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Study of cytostatic and cytotoxic characteristics of modified peptide CDK4/6 inhibitors – functional analogs of p16INK4a (90-97) by Bozhenko, V. K., Kulinich, T. M., Kudinova, E. A., Ivanov, A. V., Shishkin, A. M., Solodkiy, V. A.

“…Background. Application of mathematical modeling for search for biologically active molecules is currently a promising scientific approach. Application of…”
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The Study of mRNA Expression Profiles of Main Cell Function Regulator Genes in Unchanged Colon Mucosa from Healthy Donors by Zakharenko, M. V., Bozhenko, V. K., Kiseleva, Ya. Yu, Dzhikiya, E. L., Stanoevich, U. S., Kulinich, T. M., Melnikova, N. V., Senchukova, A. L., Urakova, A. B., Grunin, I. B., Goncharov, S. V., Bliznyukov, O. P., Solodkiy, V. A.

“…A comparative analysis of molecular genetic phenotypes of mucous membrane cells has been carried out in five anatomical regions of the large intestine in a…”
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Investigation of the expression level of genes-markers of proliferative activity in the mucosa at normal and various pathologies of the colon by Kulinich, T. M., Zakharenko, M. V., Dzhikiya, E. L., Senchukova, A. L., Stanoevich, U. S., Grunin, I. B., Melnikova, N. V., Goncharov, S. V., Krashikhina, T. V., Kudinova, E. A., Bliznyukov, O. P., Bozhenko, V. K.

“…Background. The search for molecular markers of colon diseases allowing highly specific and sensitive identification and differentiation of pathological…”
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Changes in the concentration of freely circulating mutant DNA and wild-type DNA of the H3F3А (K27M) gene in the blood and cerebrospinal fluid of children with diffuse midline gliomas during a course of radiation therapy by O. S. Regentova, V. K. Bozhenko, E. A. Kudinova, T. M. Kulinich, E. L. Dzhikiya, V. V. Kaminskiy, F. F. Antonenko, R. A. Parkhomenko, N. I. Zelinskaya, N. Sidibe, P. V. Polushkin, A. I. Shevtsov, M. A. Bliznichenko, V. A. Solodkiy

“…Purpose of the study. To study the possibility of detecting freely circulating DNA of the H3F3A (K27M) gene in blood plasma and cerebrospinal fluid in the…”
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Cytostatic and cytotoxic properties of chimeric peptides containing cyclin-inhibiting fragments by Kulinich, T. M., Kharchenko, V. P., Filyasova, E. I., Shishkin, A. M., Bozhenko, V. K.

“…Properties of chimeric peptides containing cell-penetrating sequences and p16INK4a and E2F fragments were studied in vitro on immurtal cultures of human cells…”
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Results from the First Biological Experiments on FLASH Therapy on the Accelerator at the Russian Academy of Sciences’ Institute for Nuclear Research by Akulinichev, S. V., Bozhenko, V. K., Gavrilov, Yu. K., Kokontsev, D. A., Kulinich, T. M., Martynova, V. V., Pozhenko, N. S., Shishkin, A. M., Yakovlev, I. A.

“…Modern means of radiation therapy are limited by the toxicity and healthy tissues overexposure . FLASH proton therapy is an innovative technique designed to…”
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Safety assessment and determination of a maximally tolerated dose of an RAS-GTPase inhibitor (iRAS) in the treatment of gastrointestinal tumors: preliminary results of the phase I trial by Bozhenko, Vladimir K., Goncharov, Sergey V., Kudinova, Elena A., Kulinich, Tatiana M., Kukoleva, Elena A., Filippov, Mikhail S., Bykova, Anna F., Knyazeva, Oksana B., Puchkov, Ilya A., Solodkiy, Vladimir A.

“…Background: Ras oncogene mutations leading to hyperactivation of the MAPK/ERK signaling pathway occur in 25% of all human tumors, and for gastrointestinal…”
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Comparison of Biological Effects of [gamma]-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells by Bozhenko, V.K, Ivanov, A.V, Kulinich, T.M, Smirnov, V.P, Shishkin, A.M, Solodky, V.A

“…We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic…”
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Ductal cytofluorometry of urine sediment level in the diagnosis of bladder cancer by Kaprin, A D, Bozhenko, V K, Kulinich, T M, Nesterov, P V, Kostin, A A

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Effect of metabolizable peptide p16INK4a on short-lived human tumor cultures by Bozhenko, V K, Kulinich, T M, Ivanov, A V, Kudinova, E A, Shishkin, A M, Kharchenko, V P

“…The study was concerned with antitumor action of internalized peptide incorporating a fragment of p161INK4a using a model of short-lived human tumor cultures…”
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Use of flow cytometry in diagnosis of urinary bladder cancer by Bozhenko, V K, Kaprin, A D, Kostin, A A, Kulinich, T M, Kudinova, E A, Chazova, N L, Mel'nikova, N V, Nesterov, P V

“…Urinary bladder cancer ranks 11th (10-15 cases per 100,000 annually) in the oncological morbidity registry. Morphological diagnosis is generally confirmed by…”
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Ductal cytometry of urinary sediment in the diagnosis of bladder cancer by Bozhenko, B K, Kaprin, A D, Kulinich, T M, Nesterov, P V

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