Search Results - "Kulikova, Elizabeth A."
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Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish ( Danio rerio )
Published in International journal of molecular sciences (27-11-2021)“…The mechanisms of resistance to antidepressant drugs is a key and still unresolved problem of psychopharmacology. Serotonin (5-HT) and brain-derived…”
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On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153
Published in International journal of molecular sciences (04-01-2023)“…The (brain-derived neurotrophic factor) gene contains eight regulatory exons (I-VIII) alternatively spliced to the protein-coding exon IX. Only exons I, II,…”
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Kaiso Protein in the Regulation of Brain and Behavior
Published in Current protein & peptide science (01-01-2018)“…Kaiso is a bimodal transcriptional repressor. It binds methylated CpG islands or the sequence- specific consensus in the DNA molecule with the Kaiso…”
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Age-Related Alterations in the Behavior and Serotonin-Related Gene mRNA Levels in the Brain of Males and Females of Short-Lived Turquoise Killifish ( Nothobranchius furzeri )
Published in Biomolecules (Basel, Switzerland) (28-09-2021)“…Short-lived turquoise killifish ( ) have become a popular model organism for neuroscience. In the present paper we study for the first time their behavior in…”
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Knockout of the Tnfa Gene Decreases Influenza Virus-Induced Histological Reactions in Laboratory Mice
Published in International journal of molecular sciences (18-01-2024)“…Tumor necrosis factor alpha (TNF-α) is a cytokine that is responsible for many processes associated with immune response and inflammation. It is involved in…”
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Alterations of STEP46 and STEP61 Expression in the Rat Retina with Age and AMD-Like Retinopathy Development
Published in International journal of molecular sciences (22-07-2020)“…Tyrosine phosphatase STEP (striatal-enriched tyrosine protein phosphatase) is a brain-specific protein phosphatase and is involved in the pathogenesis of many…”
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C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress
Published in Neuroscience letters (15-02-2017)“…•C1473G polymorphism in Tph2 gene regulates enzyme activity in mouse brain.•The stress-induced c-Fos mRNA rise is more intensive in the brain of B6-1473G…”
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Knockout Zbtb33 gene results in an increased locomotion, exploration and pre-pulse inhibition in mice
Published in Behavioural brain research (15-01-2016)“…•Kaiso-deficient mice show increased locomotor activity.•Reduction of the lateral ventricles volume is observed in Kaiso-deficient mice.•Kaiso deficiency…”
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Tryptophan hydroxylase 2 as a therapeutic target for psychiatric disorders: focus on animal models
Published in Expert opinion on therapeutic targets (03-08-2019)“…: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human gene are…”
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On association of the lethal yellow (AY) mutation in the agouti gene with the alterations in mouse brain and behavior
Published in Behavioural brain research (01-02-2019)“…•Mutation AY increases depressive like behavior in the forced swim test in mice.•AY/a mice have reduced volume of cortex compared with their wild-type…”
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Effects of the Cc2d1a/Freud-1 Knockdown in the Hippocampus of BTBR Mice on the Autistic-Like Behavior, Expression of Serotonin 5-HT1A and D2 Dopamine Receptors, and CREB and NF-kB Intracellular Signaling
Published in Biochemistry (Moscow) (01-10-2022)“…The mechanisms of autism are of extreme interest due to the high prevalence of this disorder in the human population. In this regard, special attention is…”
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Key Enzymes of the Serotonergic System – Tryptophan Hydroxylase 2 and Monoamine Oxidase A – In the Brain of Rats Selectively Bred for a Reaction toward Humans: Effects of Benzopentathiepin TC-2153
Published in Biochemistry (Moscow) (01-06-2024)“…At the Institute of Cytology and Genetics (Novosibirsk, Russia) for over 85 generations, gray rats have been selected for high aggression toward humans…”
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Effect of photoperiodic alterations on depression-like behavior and the brain serotonin system in mice genetically different in tryptophan hydroxylase 2 activity
Published in Neuroscience letters (23-04-2019)“…•C1473G polymorphism decreases the expression of Htr2a gene in hippocampus in mice.•Exposition to short day increases depressive-like immobility in B6–1473C…”
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The neuropeptide cycloprolylglycine produces antidepressant-like effect and enhances BDNF gene expression in the mice cortex
Published in Journal of psychopharmacology (Oxford) (01-02-2022)“…Background: Cycloprolylglycine (CPG) is an endogenous dipeptide with a wide range of psychotropic activity and putative therapeutic potential for depression. A…”
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Studying the Brain Monoaminergic Systems and Neurotrophic Factors in Minipigs with High and Low Tolerance to the Presence of Human
Published in Brain, behavior and evolution (01-06-2023)“…Here, we present the first evidence for brain adaptation in pigs tolerant to the human presence, as a behavioral trait favoring domestication. The study was…”
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5-HT2A receptors control body temperature in mice during LPS-induced inflammation via regulation of NO production
Published in Pharmacological research (01-01-2016)“…[Display omitted] G protein-coupled 5-HT2A receptors are involved in the regulation of numerous normal and pathological physiological functions. At the same…”
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No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice
Published in Neuroscience letters (13-07-2017)“…•C1473G polymorphism does not affect 5-HT, 5-HIAA, Tph2 mRNA levels in mouse brain.•Significant effect of fluoxetine on 5-HT, 5-HIAA, Tph2 mRNA levels was…”
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A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice
Published in Psychopharmacologia (01-06-2012)“…Rationale The creation of effective psychotropic drugs is the key problem of psychopharmacology. Natural compounds and their synthetic analogues attract…”
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Hereditary catalepsy in mice is associated with the brain dysmorphology and altered stress response
Published in Behavioural brain research (15-04-2013)“…► Catalepsy-prone mice had the reduced pituitary gland and enlarged thalamus. ► Restraint stress facilitates catalepsy. ► Stress-induced corticosterone…”
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Novel Approach to the Study of Fur Cleaning in Inbred Mice: Effects of Genotype, Stress, and Lipopolysaccharide
Published in ILAR journal (2010)“…Body care (grooming) is a behavioral adaptation for removing litter particles, pathogenic microbes, and parasites from animal fur and skin. It also serves as…”
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