Search Results - "Kuligina, Elena V"
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Molecular Mechanisms of Drug Resistance in Glioblastoma
Published in International journal of molecular sciences (15-06-2021)“…Glioblastoma multiforme (GBM) is the most common and fatal primary brain tumor, is highly resistant to conventional radiation and chemotherapy, and is not…”
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Regulatory Role of Small Nucleolar RNAs in Human Diseases
Published in BioMed research international (01-01-2015)“…Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells. The canonical function of box C/D and box H/ACA snoRNAs is…”
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Tumor Cell-Specific 2′-Fluoro RNA Aptamer Conjugated with Closo-Dodecaborate as A Potential Agent for Boron Neutron Capture Therapy
Published in International journal of molecular sciences (07-07-2021)“…Boron neutron capture therapy (BNCT) is a binary radiotherapeutic approach to the treatment of malignant tumors, especially glioblastoma, the most frequent and…”
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Aptamers for Addressed Boron Delivery in BNCT: Effect of Boron Cluster Attachment Site on Functional Activity
Published in International journal of molecular sciences (24-12-2022)“…Among the great variety of anti-cancer therapeutic strategies, boron neutron capture therapy (BNCT) represents a unique approach that doubles the targeting…”
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Tumor-Targeting Peptides Search Strategy for the Delivery of Therapeutic and Diagnostic Molecules to Tumor Cells
Published in International journal of molecular sciences (30-12-2020)“…The combination of the unique properties of cancer cells makes it possible to find specific ligands that interact directly with the tumor, and to conduct…”
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Characterizing Aptamer Interaction with the Oncolytic Virus VV-GMCSF-Lact
Published in Molecules (Basel, Switzerland) (01-02-2024)“…Aptamers are currently being investigated for their potential to improve virotherapy. They offer several advantages, including the ability to prevent the…”
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Human Blood Extracellular Vesicles Activate Transcription of NF-kB-Dependent Genes in A549 Lung Adenocarcinoma Cells
Published in Current issues in molecular biology (30-11-2022)“…Extracellular vesicles (EVs) produced by various cell types are heterogeneous in size and composition. Changes in the RNA sets of EVs in biological fluids are…”
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Aptamers Enhance Oncolytic Viruses' Antitumor Efficacy
Published in Pharmaceutics (31-12-2022)“…Oncolytic viruses are highly promising for cancer treatment because they target and lyse tumor cells. These genetically engineered vectors introduce…”
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Structural and Aggregation Features of a Human κ-Casein Fragment with Antitumor and Cell-Penetrating Properties
Published in Molecules (Basel, Switzerland) (12-08-2019)“…Intrinsically disordered proteins play a central role in dynamic regulatory and assembly processes in the cell. Recently, a human κ-casein proteolytic fragment…”
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10
Characterization of primary normal and malignant breast cancer cell and their response to chemotherapy and immunostimulatory agents
Published in BMC cancer (09-07-2018)“…The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic…”
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MicroRNA and mRNA Expression Changes in Glioblastoma Cells Cultivated under Conditions of Neurosphere Formation
Published in Current issues in molecular biology (30-10-2022)“…Glioblastoma multiforme (GBM) is one of the most highly metastatic cancers. The study of the pathogenesis of GBM, as well as the development of targeted…”
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12
Tumor-Specific Peptide, Selected from a Phage Peptide Library, Enhances Antitumor Activity of Lactaptin
Published in PloS one (11-08-2016)“…A recombinant analogue of lactaptin (RL2), a new potential anticancer molecule, induces apoptosis in cultured tumor cells. The tumor suppression efficacy of…”
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Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts
Published in PloS one (01-04-2014)“…Lactaptin, the proteolytic fragment of human milk kappa-casein, induces the death of various cultured cancer cells. The mechanisms leading to cell death after…”
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Transcriptome Changes in Glioma Cells Cultivated under Conditions of Neurosphere Formation
Published in Cells (Basel, Switzerland) (01-10-2022)“…Glioma is the most common and heterogeneous primary brain tumor. The development of a new relevant preclinical models is necessary. As research moves from…”
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Transcriptome Changes in Glioma Cells upon Infection with the Oncolytic Virus VV-GMCSF-Lact
Published in Cells (Basel, Switzerland) (01-11-2023)“…Oncolytic virotherapy is a rapidly evolving approach that aims to selectively kill cancer cells. We designed a promising recombinant vaccinia virus,…”
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16
Variety of RNAs in Peripheral Blood Cells, Plasma, and Plasma Fractions
Published in BioMed research international (01-01-2017)“…Human peripheral blood contains RNA in cells and in extracellular membrane vesicles, microvesicles and exosomes, as well as in cell-free ribonucleoproteins…”
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Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors
Published in BioMed research international (2019)“…Autophagy is a degradative process in which cellular organelles and proteins are recycled to restore homeostasis and cellular metabolism. Autophagy can be…”
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Vesicular and Extra-Vesicular RNAs of Human Blood Plasma
Published in Advances in experimental medicine and biology (2016)“…Human blood contains a great variety of membrane-covered RNA carrying vesicles which are spherical or tubular particles enclosed by a phospholipid bilayer…”
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Artificial Analogues of Circulating Box C/D RNAs Induce Strong Innate Immune Response and MicroRNA Activation in Human Adenocarcinoma Cells
Published in Advances in experimental medicine and biology (2016)“…Fragments of small nucleolar RNAs (snoRNAs) were found among various non-coding RNAs (ncRNAs) circulating in human blood. Currently, the function of such…”
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Analysis of the efficiency of recombinant Escherichia coli strain cultivation in a gas‐vortex bioreactor
Published in Biotechnology and applied biochemistry (01-09-2017)“…The levels of aeration and mass transfer are critical parameters required for an efficient aerobic bioprocess, and directly depend on the design features of…”
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