Search Results - "Kulesa, Paul M"

Multiscale mechanisms of cell migration during development: theory and experiment by McLennan, Rebecca, Dyson, Louise, Prather, Katherine W, Morrison, Jason A, Baker, Ruth E, Maini, Philip K, Kulesa, Paul M

“…Long-distance cell migration is an important feature of embryonic development, adult morphogenesis and cancer, yet the mechanisms that drive subpopulations of…”
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Neural crest cells bulldoze through the microenvironment using Aquaporin 1 to stabilize filopodia by McLennan, Rebecca, McKinney, Mary C, Teddy, Jessica M, Morrison, Jason A, Kasemeier-Kulesa, Jennifer C, Ridenour, Dennis A, Manthe, Craig A, Giniunaite, Rasa, Robinson, Martin, Baker, Ruth E, Maini, Philip K, Kulesa, Paul M

“…Neural crest migration requires cells to move through an environment filled with dense extracellular matrix and mesoderm to reach targets throughout the…”
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Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration by Martinson, William Duncan, McLennan, Rebecca, Teddy, Jessica M, McKinney, Mary C, Davidson, Lance A, Baker, Ruth E, Byrne, Helen M, Kulesa, Paul M, Maini, Philip K

“…Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this…”
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CXCR4 controls ventral migration of sympathetic precursor cells by Kasemeier-Kulesa, Jennifer C, McLennan, Rebecca, Romine, Morgan H, Kulesa, Paul M, Lefcort, Frances

“…The molecular mechanisms that sort migrating neural crest cells (NCCs) along a shared pathway into two functionally discrete structures, the dorsal root…”
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Single-cell transcriptome analysis of avian neural crest migration reveals signatures of invasion and molecular transitions by Morrison, Jason A, McLennan, Rebecca, Wolfe, Lauren A, Gogol, Madelaine M, Meier, Samuel, McKinney, Mary C, Teddy, Jessica M, Holmes, Laura, Semerad, Craig L, Box, Andrew C, Li, Hua, Hall, Kathryn E, Perera, Anoja G, Kulesa, Paul M

“…Neural crest cells migrate throughout the embryo, but how cells move in a directed and collective manner has remained unclear. Here, we perform the first…”
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In vivo evidence for short- and long-range cell communication in cranial neural crest cells by Teddy, Jessica M, Kulesa, Paul M

“…The proper assembly of craniofacial structures and the peripheral nervous system requires neural crest cells to emerge from the neural tube and navigate over…”
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The neural crest cell cycle is related to phases of migration in the head by Ridenour, Dennis A, McLennan, Rebecca, Teddy, Jessica M, Semerad, Craig L, Haug, Jeffrey S, Kulesa, Paul M

“…Embryonic cells that migrate long distances must critically balance cell division in order to maintain stream dynamics and population of peripheral targets…”
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In vivo analysis reveals a critical role for neuropilin-1 in cranial neural crest cell migration in chick by McLennan, Rebecca, Kulesa, Paul M.

“…The neural crest provides an excellent model system to study invasive cell migration, however it is still unclear how molecular mechanisms direct cells to…”
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Multidisciplinary approaches to understanding collective cell migration in developmental biology by Schumacher, Linus J., Kulesa, Paul M., McLennan, Rebecca, Baker, Ruth E., Maini, Philip K.

“…Mathematical models are becoming increasingly integrated with experimental efforts in the study of biological systems. Collective cell migration in…”
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Reprogramming Metastatic Melanoma Cells to Assume a Neural Crest Cell-Like Phenotype in an Embryonic Microenvironment by Kulesa, Paul M., Kasemeier-Kulesa, Jennifer C., Teddy, Jessica M., Margaryan, Naira V., Seftor, Elisabeth A., Seftor, Richard E. B., Hendrix, Mary J. C.

“…Human metastatic melanoma cells express a dedifferentiated, plastic phenotype, which may serve as a selective advantage, because melanoma cells invade various…”
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Quantitative single cell gene expression profiling in the avian embryo by Morrison, Jason A., Box, Andrew C., McKinney, Mary C., McLennan, Rebecca, Kulesa, Paul M.

“…Background: Single cell gene profiling has been successfully applied to cultured cells. However, isolation and preservation of a cell's native gene expression…”
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Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia by Kasemeier-Kulesa, Jennifer C, Bradley, Roger, Pasquale, Elena B, Lefcort, Frances, Kulesa, Paul M

“…Previous studies have suggested that the segmental pattern of neural-crest-derived sympathetic ganglia arises as a direct result of signals that restrict…”
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An in vivo comparison of photoactivatable fluorescent proteins in an avian embryo model by Stark, Danny A., Kulesa, Paul M.

“…Tracing the lineage or neighbor relationships of cells in a migratory population or deep within an embryo is difficult with current methods. The recent…”
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Imaging neural crest cell dynamics during formation of dorsal root ganglia and sympathetic ganglia by Kasemeier-Kulesa, J C, Kulesa, P M, Lefcort, F

“…The neural crest is a migratory population of cells that produces many diverse structures within the embryo. Trunk neural crest cells give rise to such…”
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A role for RhoA in the two-phase migratory pattern of post-otic neural crest cells by Rupp, Paul A., Kulesa, Paul M.

“…Neural crest (NC) cells have been elegantly traced to follow stereotypical migratory pathways throughout the vertebrate embryo, yet we still lack complete…”
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Cell Dynamics during Somite Boundary Formation Revealed by Time-Lapse Analysis by Kulesa, Paul M., Fraser, Scott E.

“…We follow somite segmentation in living chick embryos and find that the shaping process is not a simple periodic slicing of tissue blocks but a much more…”
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Developmental imaging: The avian embryo hatches to the challenge by Kulesa, Paul M., McKinney, Mary C., McLennan, Rebecca

“…The avian embryo provides a multifaceted model to study developmental mechanisms because of its accessibility to microsurgery, fluorescence cell labeling, in…”
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NGF reprograms metastatic melanoma to a bipotent glial-melanocyte neural crest-like precursor by Kasemeier-Kulesa, Jennifer C, Romine, Morgan H, Morrison, Jason A, Bailey, Caleb M, Welch, Danny R, Kulesa, Paul M

“…Melanoma pathogenesis from normal neural crest-derived melanocytes is often fatal due to aggressive cell invasion throughout the body. The identification of…”
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Live Imaging of the Neural Crest Cell Epithelial-to-Mesenchymal Transition in the Chick Embryo by McKinney, Mary Cathleen, Kulesa, Paul M

“…Live embryo imaging may provide a wealth of information on intact cell and tissue dynamics, but can be technically challenging to sustain embryo orientation…”
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In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis by McLennan, Rebecca, Kulesa, Paul M

“…In ovo electroporation enables transfection of non-viral plasmid DNA and/or morpholinos to fluorescently label and/or perturb gene function in cells of…”
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