Search Results - "Kulbay, Merve"

The role of the DFF40/CAD endonuclease in genomic stability by Kulbay, Merve, Bernier-Parker, Nathan, Bernier, Jacques

“…Maintenance of genomic stability in cells is primordial for cellular integrity and protection against tumor progression. Many factors such as ultraviolet…”
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In vitro and in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis by Benabdoun, Houda Abir, Kulbay, Merve, Rondon, Elsa-Patricia, Vallières, Francis, Shi, Qin, Fernandes, Julio, Fahmi, Hassan, Benderdour, Mohamed

“…Resolvin D1 (RvD1), an important member of resolvins, exerts a wide spectrum of biological effects, including resolution of inflammation, tissue repair, and…”
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An Overview of the Dry Eye Disease in Sjögren's Syndrome Using Our Current Molecular Understanding by Wu, Kevin Y, Kulbay, Merve, Tanasescu, Cristina, Jiao, Belinda, Nguyen, Bich H, Tran, Simon D

“…Sjögren's syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present…”
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Nonspecific Orbital Inflammation (NSOI): Unraveling the Molecular Pathogenesis, Diagnostic Modalities, and Therapeutic Interventions by Wu, Kevin Y, Kulbay, Merve, Daigle, Patrick, Nguyen, Bich H, Tran, Simon D

“…Nonspecific orbital inflammation (NSOI), colloquially known as orbital pseudotumor, sometimes presents a diagnostic and therapeutic challenge in ophthalmology…”
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The RyfA small RNA regulates oxidative and osmotic stress responses and virulence in uropathogenic Escherichia coli by Bessaiah, Hicham, Pokharel, Pravil, Loucif, Hamza, Kulbay, Merve, Sasseville, Charles, Habouria, Hajer, Houle, Sébastien, Bernier, Jacques, Massé, Éric, Van Grevenynghe, Julien, Dozois, Charles M

“…Urinary tract infections (UTIs) are a common bacterial infectious disease in humans, and strains of uropathogenic Escherichia coli (UPEC) are the most frequent…”
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Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development by Wu, Kevin Y, Kulbay, Merve, Toameh, Dana, Xu, An Qi, Kalevar, Ananda, Tran, Simon D

“…Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by progressive degeneration of retinal photoreceptors leading to…”
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Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies by Kulbay, Merve, Wu, Kevin Y, Nirwal, Gurleen K, Bélanger, Paul, Tran, Simon D

“…This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in cataract formation and evaluates the potential of antioxidant…”
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Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications by Kulbay, Merve, Wu, Kevin Y., Truong, Doanh, Tran, Simon D.

“…This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning…”
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The Role of Reactive Oxygen Species in Age-Related Macular Degeneration: A Comprehensive Review of Antioxidant Therapies by Kulbay, Merve, Wu, Kevin Y, Nirwal, Gurleen K, Bélanger, Paul, Tran, Simon D

“…This review article delves into the intricate roles of reactive oxygen species (ROS) in the pathogenesis of age-related macular degeneration (AMD). It presents…”
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Uveal Melanoma: Comprehensive Review of Its Pathophysiology, Diagnosis, Treatment, and Future Perspectives by Kulbay, Merve, Marcotte, Emily, Remtulla, Raheem, Lau, Tsz Hin Alexander, Paez-Escamilla, Manuel, Wu, Kevin Y, Burnier, Jr, Miguel N

“…Uveal melanoma (UM) is the most common intraocular malignancy in adults. Recent advances highlight the role of tumor-derived extracellular vesicles (TEV) and…”
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Review of cancer cell resistance mechanisms to apoptosis and actual targeted therapies by Kulbay, Merve, Paimboeuf, Adeline, Ozdemir, Derman, Bernier, Jacques

“…The apoptosis pathway is a programmed cell death mechanism that is crucial for cellular and tissue homeostasis and organ development. There are three major…”
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Clinical Impact and Outcomes of Socioeconomic Status on Patients with Sickle Cell Disease: A Pilot Study and Literature Review by Ozdemir, Derman, Kulbay, Merve, Erdinc, Burak, Avezbakiyev, Boris

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DNA fragmentation factor 40 expression in T cells confers sensibility to tributyltin-induced apoptosis by Kulbay, Merve, Johnson, Bruno, Bernier, Jacques

“…DNA fragmentation factor 40 (DFF40), an endonuclease, mediates the final and irreversible step of apoptosis by conducting oligonucleosomal DNA fragmentation…”
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TAMI-14. REDUCTION IN S. CEREVISIAE GROWTH AND CELL VIABILITY IN RESPONSE TO D-2-HYDROXYGLUTARATE ACCUMULATION IS DAMPENED BY GROWTH CONDITIONS PERMISSIVE OF OXIDATIVE PHOSPHORYLATION by Fiola, Sophie, Kulbay, Merve, Beaulieu, Jamie, Diaz, Roberto

“…Abstract BACKGROUND Elevated levels of D-2-hydroxyglutarate (D2HG) have been detected in several cancers, including IDH1/2 mutant gliomas, PHGDH-amplified…”
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DFF40 deficiency in cancerous T cells is implicated in chemotherapy drug sensitivity and resistance through the regulation of the apoptotic pathway by Kulbay, Merve, Johnson, Bruno, Fiola, Sophie, Diaz, Roberto J., Bernier, Jacques

“…[Display omitted] The regulation of the apoptotic pathway is one of the most studied mechanisms regarding cancer cell resistance. Many mutations have been…”
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Energetic metabolic reprogramming in Jurkat DFF40-deficient cancer cells by Kulbay, Merve, Johnson, Bruno, Ricaud, Guillaume, Séguin-Grignon, Marie-Noëlle, Bernier, Jacques

“…DNA fragmentation factor 40 (DFF40), or the caspase-activated DNase (CAD), is an endonuclease specific for double-stranded DNA. Alterations in its function and…”
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Exploring the impact of Choroideremia on women with phenotypic and/or genotypic evidence of disease: insights from a global survey by Bonneau, Steven, Kulbay, Merve, Kahn-Ali, Shigufa, Qian, Cynthia X

“…Choroideremia (CHM) is an X-linked inherited retinal disease mostly affecting males. However, women with phenotypic and/or genotypic evidence of CHM may…”
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A Comprehensive Review of Thyroid Eye Disease Pathogenesis: From Immune Dysregulations to Novel Diagnostic and Therapeutic Approaches by Kulbay, Merve, Tanya, Stuti M, Tuli, Nicolas, Dahoud, Jade, Dahoud, Andrea, Alsaleh, Fares, Arthurs, Bryan, El-Hadad, Christian

“…Thyroid eye disease is a complex inflammatory disorder of the orbit that has gained tremendous interest over the past years, and numerous scientific efforts…”
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Inter-visit and inter-reader reproducibility of multi-parametric diffusion-weighted MR imaging in longitudinally imaged patients with metabolic dysfunction-associated fatty liver disease and healthy volunteers by Volniansky, Anton, Lefebvre, Thierry L., Kulbay, Merve, Fan, Boyan, Aslan, Emre, Vu, Kim-Nhien, Montagnon, Emmanuel, Nguyen, Bich Ngoc, Sebastiani, Giada, Giard, Jeanne-Marie, Sylvestre, Marie-Pierre, Gilbert, Guillaume, Cloutier, Guy, Tang, An

“…Despite the widespread use of diffusion-weighted imaging (DWI) in metabolic dysfunction-associated fatty liver disease (MAFLD), MRI acquisition and…”
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Orbital inflammatory disease as a presenting feature of suspected Lyme neuroborreliosis: case report by Tanya, Stuti M., Kulbay, Merve, Remtulla, Raheem, Pundir, Sheetal, Arthurs, Bryan, El-Hadad, Christian

“…Orbital inflammatory disease (OID) is an inflammatory condition of the orbital and periorbital region. This case reports suspected Lyme neuroborreliosis…”
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