Search Results - "Kular, L"

Epigenetic insights into multiple sclerosis disease progression by Kular, L., Jagodic, M.

“…Multiple sclerosis (MS), a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system, is today a leading cause of…”
Get full text

The CCN family: A new class of inflammation modulators? by Kular, L., Pakradouni, J., Kitabgi, P., Laurent, M., Martinerie, C.

“…Uncontrolled or sustained inflammation is the underlying cause of or actively contributes to the progression of many chronic pathologies such as…”
Get full text

Decreased Expression of IFNG‐AS1, IFNG and IL‐1B Inflammatory Genes in Medicated Schizophrenia and Bipolar Patients by Ghafelehbashi, H., Pahlevan Kakhki, M., Kular, L., Moghbelinejad, S., Ghafelehbashi, S. H.

“…Although aberrant expression of cytokines such as IL‐1B and IFNG in blood from psychiatric patients supports a role of inflammation in the pathogenesis of the…”
Get full text

NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through β1 and β5 integrins by Le Dréau, G., Kular, L., Nicot, A.B., Calmel, C., Melik-Parsadaniantz, S., Kitabgi, P., Laurent, M., Martinerie, C.

“…Increasing evidence suggests that CCN matricellular proteins play important roles in inflammation. One of the major cell types that handle inflammation in the…”
Get full text

Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview by Piket, Eliane, Zheleznyakova, Galina Yurevna, Kular, Lara, Jagodic, Maja

“…Multiple sclerosis (MS) is a leading cause of progressive disability among young adults caused by inflammation, demyelination and axonal loss in the central…”
Get full text

The lung-brain axis in multiple sclerosis: Mechanistic insights and future directions by Kular, Lara

“…Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system with progressive lifelong disability. Current treatments are…”
Get full text

Epigenetics applied to psychiatry: Clinical opportunities and future challenges by Kular, Lara, Kular, Sonia

“…Psychiatric disorders are clinically heterogeneous and debilitating chronic diseases resulting from a complex interplay between gene variants and environmental…”
Get full text

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells by Lund, Harald, Pieber, Melanie, Parsa, Roham, Han, Jinming, Grommisch, David, Ewing, Ewoud, Kular, Lara, Needhamsen, Maria, Espinosa, Alexander, Nilsson, Emma, Överby, Anna K., Butovsky, Oleg, Jagodic, Maja, Zhang, Xing-Mei, Harris, Robert A.

“…Circulating monocytes can compete for virtually any tissue macrophage niche and become long-lived replacements that are phenotypically indistinguishable from…”
Get full text

DNA methylation as a mediator of HLA-DRB1 15:01 and a protective variant in multiple sclerosis by Kular, Lara, Liu, Yun, Ruhrmann, Sabrina, Zheleznyakova, Galina, Marabita, Francesco, Gomez-Cabrero, David, James, Tojo, Ewing, Ewoud, Lindén, Magdalena, Górnikiewicz, Bartosz, Aeinehband, Shahin, Stridh, Pernilla, Link, Jenny, Andlauer, Till F.M, Gasperi, Christiane, Wiendl, Heinz, Zipp, Frauke, Gold, Ralf, Tackenberg, Björn, Weber, Frank, Hemmer, Bernhard, Strauch, Konstantin, Heilmann-Heimbach, Stefanie, Rawal, Rajesh, Schminke, Ulf, Schmidt, Carsten O, Kacprowski, Tim, Franke, Andre, Laudes, Matthias, Dilthey, Alexander T, Celius, Elisabeth Gulowsen, Søndergaard, Helle Bach, Tegnér, Jesper, Harbo, Hanne Flinstad, Oturai, Annette B, Olafsson, Sigurgeir, Eggertsson, Hannes P, Halldorsson, Bjarni V, Hjaltason, Haukur, Olafsson, Elias, Jonsdottir, Ingileif, Stefansson, Kari, Olsson, Tomas, Piehl, Fredrik, Ekström, Tomas J, Kockum, Ingrid, Feinberg, Andrew P, Jagodic, Maja

“…The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated…”
Get full text

Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS by Windener, Farina, Grewing, Laureen, Thomas, Christian, Dorion, Marie-France, Otteken, Marie, Kular, Lara, Jagodic, Maja, Antel, Jack, Albrecht, Stefanie, Kuhlmann, Tanja

“…Aging affects all cell types in the CNS and plays an important role in CNS diseases. However, the underlying molecular mechanisms driving these age-associated…”
Get full text

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients by Kular, Lara, Ewing, Ewoud, Needhamsen, Maria, Pahlevan Kakhki, Majid, Covacu, Ruxandra, Gomez-Cabrero, David, Brundin, Lou, Jagodic, Maja

“…Multiple Sclerosis (MS), the leading cause of non-traumatic neurological disability in young adults, is a chronic inflammatory and neurodegenerative disease of…”
Get full text

Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration by Li, Dongqing, Kular, Lara, Vij, Manika, Herter, Eva K., Li, Xi, Wang, Aoxue, Chu, Tongbin, Toma, Maria-Alexandra, Zhang, Letian, Liapi, Eleni, Mota, Ana, Blomqvist, Lennart, Sérézal, Irène Gallais, Rollman, Ola, Wikstrom, Jakob D., Bienko, Magda, Berglund, David, Ståhle, Mona, Sommar, Pehr, Jagodic, Maja, Landén, Ning Xu

“…An increasing number of studies reveal the importance of long noncoding RNAs (lncRNAs) in gene expression control underlying many physiological and…”
Get full text

C-type lectin receptors Mcl and Mincle contro development of multiple sclerosis like neuroinflammation by N'diaye, M, Brauner, S, Flytzani, S, Kular, L, Warnecke, A, Adzemovic, MZ, Piket, E, Min, J-H, Edwards, W, Mela, F

Get full text

Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis by Maltby, Vicki, Xavier, Alexandre, Ewing, Ewoud, Campagna, Maria-Pia, Sampangi, Sandeep, Scott, Rodney J, Butzkueven, Helmut, Jokubaitis, Vilija, Kular, Lara, Bos, Steffan, Slee, Mark, van der Mei, Ingrid A, Taylor, Bruce V, Ponsonby, Anne-Louise, Jagodic, Maja, Lea, Rodney, Lechner-Scott, Jeannette

“…In multiple sclerosis (MS), accelerated aging of the immune system (immunosenescence) may be associated with disease onset or drive progression. DNA…”
Get full text

Epigenetic changes in the CYP2D6 gene are related to severity of suicide attempt: A cross-sectional study of suicide attempters by Boström, Adrian E. Desai, Jamshidi, Esmail, Manu, Diana-Maria, Kular, Lara, Schiöth, Helgi B., Åsberg, Marie, Jokinen, Jussi

“…The ability to accurately estimate risk of suicide deaths on an individual level remains elusive. This study reports on a case-control study set-up from a…”
Get full text

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling by Lund, Harald, Pieber, Melanie, Parsa, Roham, Grommisch, David, Ewing, Ewoud, Kular, Lara, Han, Jinming, Zhu, Keying, Nijssen, Jik, Hedlund, Eva, Needhamsen, Maria, Ruhrmann, Sabrina, Guerreiro-Cacais, André Ortlieb, Berglund, Rasmus, Forteza, Maria J., Ketelhuth, Daniel F. J., Butovsky, Oleg, Jagodic, Maja, Zhang, Xing-Mei, Harris, Robert A.

“…The cytokine transforming growth factor- β (TGF- β ) regulates the development and homeostasis of several tissue-resident macrophage populations, including…”
Get full text

Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis by Lohcharoenkal, Warangkana, Das Mahapatra, Kunal, Pasquali, Lorenzo, Crudden, Caitrin, Kular, Lara, Akkaya Ulum, Yeliz Z., Zhang, Lingyun, Xu Landén, Ning, Girnita, Leonard, Jagodic, Maja, Ståhle, Mona, Sonkoly, Enikö, Pivarcsi, Andor

“…Melanoma is one of the deadliest human cancers with limited therapeutic options. MicroRNAs are a class of short noncoding RNAs regulating gene expression at…”
Get full text

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship by Marabita, Francesco, Almgren, Malin, Sjöholm, Louise K., Kular, Lara, Liu, Yun, James, Tojo, Kiss, Nimrod B., Feinberg, Andrew P., Olsson, Tomas, Kockum, Ingrid, Alfredsson, Lars, Ekström, Tomas J., Jagodic, Maja

“…Cigarette smoking is an established environmental risk factor for Multiple Sclerosis (MS), a chronic inflammatory and neurodegenerative disease, although a…”
Get full text

Smoking affects epigenetic ageing of lunch bronchoalveolar lavage cells in Multiple Sclerosis by Klose, D, Needhamsen, M, Ringh, M, Hagemann-Jensen, M, Jagodic, M, Kular, L

Get full text

The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology by Linnerbauer, Mathias, Lößlein, Lena, Vandrey, Oliver, Peter, Anne, Han, Yanan, Tsaktanis, Thanos, Wogram, Emile, Needhamsen, Maria, Kular, Lara, Nagel, Lisa, Zissler, Julia, Andert, Marie, Meszaros, Lisa, Hanspach, Jannis, Zuber, Finnja, Naumann, Ulrike J., Diebold, Martin, Wheeler, Michael A., Beyer, Tobias, Nirschl, Lucy, Cirac, Ana, Laun, Frederik B., Günther, Claudia, Winkler, Jürgen, Bäuerle, Tobias, Jagodic, Maja, Hemmer, Bernhard, Prinz, Marco, Quintana, Francisco J., Rothhammer, Veit

“…Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their…”
Get full text