Search Results - "Kukreti, Ritushree"

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases by Singh, Anju, Kukreti, Ritushree, Saso, Luciano, Kukreti, Shrikant

“…Oxidative stress is proposed as a regulatory element in ageing and various neurological disorders. The excess of oxidants causes a reduction of antioxidants,…”
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Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes by Singh, Anju, Kukreti, Ritushree, Saso, Luciano, Kukreti, Shrikant

“…Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the biochemical processes leading to elevated production of reactive oxygen…”
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Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management by Rawat, Chitra, Kukal, Samiksha, Dahiya, Ujjwal Ranjan, Kukreti, Ritushree

“…Epilepsy, a common multifactorial neurological disease, affects about 69 million people worldwide constituting nearly 1% of the world population. Despite…”
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Oxidative Stress: Role and Response of Short Guanine Tracts at Genomic Locations by Singh, Anju, Kukreti, Ritushree, Saso, Luciano, Kukreti, Shrikant

“…Over the decades, oxidative stress has emerged as a major concern to biological researchers. It is involved in the pathogenesis of various lifestyle-related…”
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Multidrug efflux transporter ABCG2: expression and regulation by Kukal, Samiksha, Guin, Debleena, Rawat, Chitra, Bora, Shivangi, Mishra, Manish Kumar, Sharma, Priya, Paul, Priyanka Rani, Kanojia, Neha, Grewal, Gurpreet Kaur, Kukreti, Shrikant, Saso, Luciano, Kukreti, Ritushree

“…The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was originally discovered in a multidrug-resistant breast cancer cell line…”
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Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment by Thakran, Sarita, Guin, Debleena, Singh, Pooja, Singh, Priyanka, Kukal, Samiksha, Rawat, Chitra, Yadav, Saroj, Kushwaha, Suman S, Srivastava, Achal K, Hasija, Yasha, Saso, Luciano, Ramachandran, Srinivasan, Kukreti, Ritushree

“…Epilepsy, a neurological disease characterized by recurrent seizures, is highly heterogeneous in nature. Based on the prevalence, epilepsy is classified into…”
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Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies by Verma, Sagar, Singh, Priyanka, Khurana, Shiffali, Ganguly, Nirmal Kumar, Kukreti, Ritushree, Saso, Luciano, Rana, Devinder Singh, Taneja, Vibha, Bhargava, Vinant

“…Moderate levels of endogenous reactive oxygen species (ROS) are important for various cellular activities, but high levels lead to toxicity and are associated…”
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Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease by Talwar, Puneet, Silla, Yumnam, Grover, Sandeep, Gupta, Meenal, Agarwal, Rachna, Kushwaha, Suman, Kukreti, Ritushree

“…Alzheimer's disease (AD) is one of the leading genetically complex and heterogeneous disorder that is influenced by both genetic and environmental factors. The…”
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Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile by Mishra, Manish Kumar, Kukal, Samiksha, Paul, Priyanka Rani, Bora, Shivangi, Singh, Anju, Kukreti, Shrikant, Saso, Luciano, Muthusamy, Karthikeyan, Hasija, Yasha, Kukreti, Ritushree

“…Valproic acid (VPA) is a well-established anticonvulsant drug discovered serendipitously and marketed for the treatment of epilepsy, migraine, bipolar disorder…”
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In Vitro Assessment of the Effect of Antiepileptic Drugs on Expression and Function of ABC Transporters and Their Interactions with ABCC2 by Grewal, Gurpreet Kaur, Kukal, Samiksha, Kanojia, Neha, Madan, Krateeka, Saso, Luciano, Kukreti, Ritushree

“…ABC transporters have a significant role in drug disposition and response and various studies have implicated their involvement in epilepsy pharmacoresistance…”
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Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance by Grewal, Gurpreet Kaur, Kukal, Samiksha, Kanojia, Neha, Saso, Luciano, Kukreti, Shrikant, Kukreti, Ritushree

“…Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures…”
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Downregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy by Rawat, Chitra, Kutum, Rintu, Kukal, Samiksha, Srivastava, Ankit, Dahiya, Ujjwal Ranjan, Kushwaha, Suman, Sharma, Sangeeta, Dash, Debasis, Saso, Luciano, Srivastava, Achal K., Kukreti, Ritushree

“…Antiepileptic drug therapy has significant inter-patient variability in response towards it. The current study aims to understand this variability at the…”
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Viral Induced Oxidative and Inflammatory Response in Alzheimer's Disease Pathogenesis with Identification of Potential Drug Candidates: A Systematic Review using Systems Biology Approach by Talwar, Puneet, Gupta, Renu, Kushwaha, Suman, Agarwal, Rachna, Saso, Luciano, Kukreti, Shrikant, Kukreti, Ritushree

“…Alzheimer’s disease (AD) is genetically complex with multifactorial etiology. Here, we aim to identify the potential viral pathogens leading to aberrant…”
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The deleterious impact of a non-synonymous SNP on protein structure and function is apparent in hypertension by Sharma, Kavita, Hema, Kanipakam, Bhatraju, Naveen Kumar, Kukreti, Ritushree, Das, Rajat Subhra, Gupta, Mohit Dayal, Syed, Mansoor Ali, Pasha, M. A. Qadar

“…Essential hypertension (EH) is a significant health issue around the globe. The indifferent therapy regimen suggests varied physiological functions due to the…”
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Validating a Genomic Convergence and Network Analysis Approach Using Association Analysis of Identified Candidate Genes in Alzheimer's Disease by Talwar, Puneet, Kushwaha, Suman, Rawat, Chitra, Kaur, Harpreet, Srivastava, Ankit, Agarwal, Rachna, Chandna, Puneet, Tucci, Paolo, Saso, Luciano, Kukreti, Ritushree

“…Previously, we demonstrated an integrated genomic convergence and network analysis approach to identify the candidate genes associated with the complex…”
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Critical evaluation of challenges and future use of animals in experimentation for biomedical research by Singh, Vijay Pal, Pratap, Kunal, Sinha, Juhi, Desiraju, Koundinya, Bahal, Devika, Kukreti, Ritushree

“…Animal experiments that are conducted worldwide contribute to significant findings and breakthroughs in the understanding of the underlying mechanisms of…”
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Systems Approach to Identify Common Genes and Pathways Associated with Response to Selective Serotonin Reuptake Inhibitors and Major Depression Risk by Srivastava, Ankit, Singh, Priyanka, Gupta, Hitesh, Kaur, Harpreet, Kanojia, Neha, Guin, Debleena, Sood, Mamta, Chadda, Rakesh Kumar, Yadav, Jyoti, Vohora, Divya, Saso, Luciano, Kukreti, Ritushree

“…Despite numerous studies on major depressive disorder (MDD) susceptibility, the precise underlying molecular mechanism has not been elucidated which restricts…”
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Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex by Verma, Meenakshi, Sharma, Abhishek, Naidu, Swarna, Bhadra, Ankan Kumar, Kukreti, Ritushree, Taneja, Vibha

“…Small molecules with antioxidative properties have been implicated in amyloid disorders. Curcumin is the active ingredient present in turmeric and known for…”
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Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure by Chanana, Neha, Palmo, Tsering, Sharma, Kavita, Kumar, Rahul, Shah, Bhushan, Mahajan, Sudhanshu, Palleda, Girish M, Gupta, Mohit D, Kukreti, Ritushree, Faruq, Mohammad, Thinlas, Tashi, Graham, Brian B, Pasha, Qadar

“…Dexamethasone can be taken prophylactically to prevent hypobaric hypoxia-associated disorders of high-altitude. While dexamethasone-mediated protection against…”
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Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients by Kaur, Harpreet, Jajodia, Ajay, Grover, Sandeep, Baghel, Ruchi, Gupta, Meenal, Jain, Sanjeev, Kukreti, Ritushree

“…Literature suggests that disease severity and neurotransmitter signaling pathway genes can accurately identify antipsychotic response in schizophrenia…”
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