Search Results - "Kukral, D"

BMS-986089 is a high affinity anti-myostatin adnectin that increases muscle volume in three preclinical species by Madireddi, M, Malone, H, Kukral, D, Chimalakonda, A, Kozhich, A, Xiling, Y, Swain, J, Yamniuk, A, Ahlijanian, M

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Prophylactic administration of abatacept prevents disease and bone destruction in a rat model of collagen-induced arthritis by Kliwinski, C., Kukral, D., Postelnek, J., Krishnan, B., Killar, L., Lewin, A., Nadler, S., Townsend, R.

“…Abatacept is the first in a new class of agents that selectively modulates T-cell activation by attenuating CD28-mediated co-stimulation. This study examined…”
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Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors by Borzilleri, Robert M, Zheng, Xiaoping, Qian, Ligang, Ellis, Christopher, Cai, Zhen-wei, Wautlet, Barri S, Mortillo, Steve, Jeyaseelan, Robert, Kukral, Daniel W, Fura, Aberra, Kamath, Amrita, Vyas, Viral, Tokarski, John S, Barrish, Joel C, Hunt, John T, Lombardo, Louis J, Fargnoli, Joseph, Bhide, Rajeev S

“…A series of substituted 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines was identified as potent and selective inhibitors of the…”
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P.14 - BMS-986089 is a high affinity anti-myostatin adnectin that increases muscle volume in three preclinical species by Madireddi, M., Malone, H., Kukral, D., Chimalakonda, A., Kozhich, A., Xiling, Y., Swain, J., Yamniuk, A., Ahlijanian, M.

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Discovery and Preclinical Studies of (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an In Vivo Active Potent VEGFR-2 Inhibitor by Bhide, Rajeev S, Cai, Zhen-Wei, Zhang, Yong-Zheng, Qian, Ligang, Wei, Donna, Barbosa, Stephanie, Lombardo, Louis J, Borzilleri, Robert M, Zheng, Xiaoping, Wu, Laurence I, Barrish, Joel C, Kim, Soong-Hoon, Leavitt, Kenneth, Mathur, Arvind, Leith, Leslie, Chao, Sam, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Kukral, Daniel, Hunt, John T, Kamath, Amrita, Fura, Aberra, Vyas, Viral, Marathe, Punit, D'Arienzo, Celia, Derbin, George, Fargnoli, Joseph

“…A series of substituted 4-(4-fluoro-1H-indol-5-yloxy)pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of vascular endothelial growth factor receptor-2 kinase is…”
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Prophylactic administration of abatacept (CTLA4-Ig; BMS-188667) prevents disease induction and bone destruction in a rat model of collagen-induced arthritis by Kliwinski, C, Kukral, D, Postelnek, J, Krishnan, B, Killar, L, Nadler, S, Townsend, R

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A function theoretic method forΔ 4 2 u+Q(x)u=0 by Gilbert, R. P., Kukral, D.

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