Search Results - "Kukla, Mike"

In Search of a Novel Anti-HIV Drug:  Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine) by Janssen, Paul A. J, Lewi, Paul J, Arnold, Eddy, Daeyaert, Frits, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Vinkers, Maarten, Guillemont, Jérôme, Pasquier, Elisabeth, Kukla, Mike, Ludovici, Don, Andries, Koen, de Béthune, Marie-Pierre, Pauwels, Rudi, Das, Kalyan, Clark, Art D, Frenkel, Yulia Volovik, Hughes, Stephen H, Medaer, Bart, De Knaep, Fons, Bohets, Hilde, De Clerck, Fred, Lampo, Ann, Williams, Peter, Stoffels, Paul

“…Ideally, an anti-HIV drug should (1) be highly active against wild-type and mutant HIV without allowing breakthrough; (2) have high oral bioavailability and…”
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On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data by Lewi, Paul J, de Jonge, Marc, Daeyaert, Frits, Koymans, Luc, Vinkers, Maarten, Heeres, Jan, Janssen, Paul A J, Arnold, Eddy, Das, Kalyan, Clark, Jr, Art D, Hughes, Stephen H, Boyer, Paul L, de Béthune, Marie-Pierre, Pauwels, Rudi, Andries, Koen, Kukla, Mike, Ludovici, Donald, De Corte, Bart, Kavash, Robert, Ho, Chih, Lewis, Paul J

“…There are several indications that a given compound or a set of related compounds can bind in different modes to a specific binding site of a protein. This is…”
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