Search Results - "Kukharsky, Michail S"

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis by Shelkovnikova, Tatyana A, Kukharsky, Michail S, An, Haiyan, Dimasi, Pasquale, Alexeeva, Svetlana, Shabir, Osman, Heath, Paul R, Buchman, Vladimir L

“…Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic…”
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Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy by Matsukawa, Koji, Kukharsky, Michail S., Park, Sei-Kyoung, Park, Sangeun, Watanabe, Naruaki, Iwatsubo, Takeshi, Hashimoto, Tadafumi, Liebman, Susan W., Shelkovnikova, Tatyana A.

“…Pathological changes involving TDP-43 protein ('TDP-43 proteinopathy') are typical for several neurodegenerative diseases, including frontotemporal lobar…”
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Editorial of the Special Issue: Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease by Ninkina, Natalia, Kukharsky, Michail S

“…Extensive studies of α-synuclein function and dysfunction revealed its involvement in multiple normal and aberrant molecular processes and, consequently,…”
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Stem cells in human breast milk by Ninkina, Natalia, Kukharsky, Michail S., Hewitt, Maria V., Lysikova, Ekaterina A., Skuratovska, Larissa N., Deykin, Alexey V., Buchman, Vladimir L.

“…Recent studies have demonstrated that breast milk contains a population of cells displaying many of the properties typical of stem cells. This review outlines…”
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Therapeutic effect of exogenous hsp70 in mouse models of Alzheimer's disease by Bobkova, Natalia V, Garbuz, David G, Nesterova, Inna, Medvinskaya, Natalia, Samokhin, Alexander, Alexandrova, Irina, Yashin, Valerii, Karpov, Vadim, Kukharsky, Michail S, Ninkina, Natalia N, Smirnov, Andrey A, Nudler, Evgeny, Evgen'ev, Michael

“…Brain deterioration resulting from "protein folding" diseases, such as the Alzheimer's disease (AD), is one of the leading causes of morbidity and mortality in…”
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Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly by Shelkovnikova, Tatyana A, Dimasi, Pasquale, Kukharsky, Michail S, An, Haiyan, Quintiero, Annamaria, Schirmer, Claire, Buée, Luc, Galas, Marie-Christine, Buchman, Vladimir L

“…Dysregulation of stress granules (SGs) and their resident proteins contributes to pathogenesis of a number of (neuro)degenerative diseases. Phosphorylation of…”
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Gamma-Synuclein Dysfunction Causes Autoantibody Formation in Glaucoma Patients and Dysregulation of Intraocular Pressure in Mice by Pavlenko, Tatiana A, Roman, Andrei Y, Lytkina, Olga A, Pukaeva, Nadezhda E, Everett, Martha W, Sukhanova, Iuliia S, Soldatov, Vladislav O, Davidova, Nina G, Chesnokova, Natalia B, Ovchinnikov, Ruslan K, Kukharsky, Michail S

“…Dysregulation of intraocular pressure (IOP) is one of the main risk factors for glaucoma. γ-synuclein is a member of the synuclein family of widely expressed…”
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Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain by Tarasova, Tatiana V, Lytkina, Olga A, Goloborshcheva, Valeria V, Skuratovskaya, Larisa N, Antohin, Alexandr I, Ovchinnikov, Ruslan K, Kukharsky, Michail S

“…Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson's disease (PD). Alpha-synuclein is a protein that is a major…”
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In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches by Kukharsky, Michail S., Skvortsova, Veronika I., Bachurin, Sergey O., Buchman, Vladimir L.

“…Recent progress in understanding the pathological changes in the nervous system and in certain other body systems (e.g., immune system) that lead to the…”
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Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice by Ninkina, Natalia, Tarasova, Tatiana V., Chaprov, Kirill D., Roman, Andrei Yu, Kukharsky, Michail S., Kolik, Larisa G., Ovchinnikov, Ruslan, Ustyugov, Aleksey A., Durnev, Andrey D., Buchman, Vladimir L.

“…The etiology and pathogenesis of Parkinson’s disease (PD) are tightly linked to the gain-of-function of α-synuclein. However, gradual accumulation of…”
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Low‐symmetry A3B‐type 6H‐1,4‐diazepinoporphyrazines with anti‐Kasha effect as promising photosensitizers by Tarakanov, Pavel A, Neganova, Margarita E, Mishchenko, Denis V, Bondarenko, Sergey D, Sergeeva, Irina A, Krot, Aleksey R, Goryachev, Nikolay S, Simakov, Anton O, Kukharsky, Michail S, Pukhov, Sergey A, Pushkarev, Victor E

“…A series of tribenzo[g,l,q]‐6H‐1,4‐diazepino[2,3‐b]porphyrazines has been synthesized. A temperature‐dependent steric effect was applied in the mixed Linstead…”
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Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice by Kukharsky, Michail S., Ninkina, Natalia N., An, Haiyan, Telezhkin, Vsevolod, Wei, Wenbin, Meritens, Camille Rabesahala de, Cooper-Knock, Johnathan, Nakagawa, Shinichi, Hirose, Tetsuro, Buchman, Vladimir L., Shelkovnikova, Tatyana A.

“…NEAT1 is a highly and ubiquitously expressed long non-coding RNA (lncRNA) which serves as an important regulator of cellular stress response. However, the…”
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Massive Proteogenomic Reanalysis of Publicly Available Proteomic Datasets of Human Tissues in Search for Protein Recoding via Adenosine-to-Inosine RNA Editing by Levitsky, Lev I., Ivanov, Mark V., Goncharov, Anton O., Kliuchnikova, Anna A., Bubis, Julia A., Lobas, Anna A., Solovyeva, Elizaveta M., Pyatnitskiy, Mikhail A., Ovchinnikov, Ruslan K., Kukharsky, Michail S., Farafonova, Tatiana E., Novikova, Svetlana E., Zgoda, Victor G., Tarasova, Irina A., Gorshkov, Mikhail V., Moshkovskii, Sergei A.

“…The proteogenomic search pipeline developed in this work has been applied for reanalysis of 40 publicly available shotgun proteomic datasets from various human…”
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Low Level of Expression of C-Terminally Truncated Human FUS Causes Extensive Changes in the Spinal Cord Transcriptome of Asymptomatic Transgenic Mice by Lysikova, Ekaterina A., Funikov, Sergei, Rezvykh, Alexander P., Chaprov, Kirill D., Kukharsky, Michail S., Ustyugov, Aleksey, Deykin, Alexey V., Flyamer, Ilya M., Boyle, Shelagh, Bachurin, Sergey O., Ninkina, Natalia, Buchman, Vladimir L.

“…A number of mutations in a gene encoding RNA-binding protein FUS have been linked to the development of a familial form of amyotrophic lateral sclerosis known…”
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Behavioural impairments in mice of a novel FUS transgenic line recapitulate features of frontotemporal lobar degeneration by Lysikova, Ekaterina A., Kukharsky, Michail S., Chaprov, Kirill D., Vasilieva, Nataliia A., Roman, Andrei Y., Ovchinnikov, Ruslan K., Deykin, Alexey V., Ninkina, Natalia, Buchman, Vladimir L.

“…Multiple clinical and experimental evidences suggest that amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are members of a…”
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A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice by Chaprov, Kirill, Rezvykh, Alexander, Funikov, Sergei, Ivanova, Tamara A., Lysikova, Ekaterina A., Deykin, Alexei V., Kukharsky, Michail S., Yu. Aksinenko, Alexey, Bachurin, Sergey O., Ninkina, Natalia, Buchman, Vladimir L.

“…Aims To assess effects of DF402, a bioisostere of Dimebon/Latrepirdine, on the disease progression in the transgenic model of amyotrophic lateral sclerosis…”
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Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice by Kulikova, Alexandra A., Cheglakov, Ivan B., Kukharsky, Michail S., Ovchinnikov, Ruslan K., Kozin, Sergey A., Makarov, Alexander A.

“…Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer’s disease patients result in the acceleration of cerebral β-amyloidosis in…”
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Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis by Kukharsky, Michail S, Quintiero, Annamaria, Matsumoto, Taisei, Matsukawa, Koji, An, Haiyan, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Buchman, Vladimir L, Shelkovnikova, Tatyana A

“…Mutations in calcium-responsive transactivator (CREST) encoding gene have been recently linked to ALS. Similar to several proteins implicated in ALS, CREST…”
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Retinal Damage in Amyotrophic Lateral Sclerosis: Underlying Mechanisms by Soldatov, Vladislav O, Kukharsky, Michail S, Belykh, Andrey E, Sobolev, Andrey M, Deykin, Alexey V

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in a gradual loss of motor neuron function. Although ophthalmic complaints…”
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C9ORF72 hexanucleotide repeat expansion in ALS patients from the Central European Russia population by Abramycheva, Natalya Y, Lysogorskaia, Elena V, Stepanova, Maria S, Zakharova, Maria N, Kovrazhkina, Elena A, Razinskaya, Olga D, Smirnov, Andrey P, Maltsev, Andrey V, Ustyugov, Alexey A, Kukharsky, Michail S, Khritankova, Inna V, Bachurin, Sergey O, Cooper-Knock, Johnathan, Buchman, Vladimir L, Illarioshkin, Sergey N, Skvortsova, Veronika I, Ninkina, Natalia

“…Abstract Cohorts of amyotrophic lateral sclerosis (ALS) patients and control individuals of Caucasian origin from the Central European Russia (Moscow city and…”
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