Search Results - "Kukharchuk, Valery V"

iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial Hypercholesterolemia by Zakharova, Irina S, Shevchenko, Alexander I, Arssan, Mhd Amin, Sleptcov, Aleksei A, Nazarenko, Maria S, Zarubin, Aleksei A, Zheltysheva, Nina V, Shevchenko, Vlada A, Tmoyan, Narek A, Saaya, Shoraan B, Ezhov, Marat V, Kukharchuk, Valery V, Parfyonova, Yelena V, Zakian, Suren M

“…Defects in the low-density lipoprotein receptor (LDLR) are associated with familial hypercholesterolemia (FH), manifested by atherosclerosis and cardiovascular…”
Get full text

Calling and Phasing of Single-Nucleotide and Structural Variants of the LDLR Gene Using Oxford Nanopore MinION by Nazarenko, Maria S, Sleptcov, Aleksei A, Zarubin, Aleksei A, Salakhov, Ramil R, Shevchenko, Alexander I, Tmoyan, Narek A, Elisaphenko, Eugeny A, Zubkova, Ekaterina S, Zheltysheva, Nina V, Ezhov, Marat V, Kukharchuk, Valery V, Parfyonova, Yelena V, Zakian, Suren M, Zakharova, Irina S

“…The locus has clinical significance for lipid metabolism, Mendelian familial hypercholesterolemia (FH), and common lipid metabolism-related diseases (coronary…”
Get full text

Induced pluripotent stem cell line ICGi036-A generated by reprogramming peripheral blood mononuclear cells from a patient with familial hypercholesterolemia caused due to compound heterozygous p.Ser177Leu/p.Cys352Arg mutations in LDLR by Zakharova, Irina S., Shevchenko, Alexander I., Tmoyan, Narek A., Elisaphenko, Eugeny A., Zubkova, Ekaterina S., Sleptcov, Aleksei A., Nazarenko, Maria S., Ezhov, Marat V., Kukharchuk, Valery V., Parfyonova, Yelena V., Zakian, Suren M.

“…Familial hypercholesterolemia (FH) is a monogenic disease, leading to atherosclerosis due to a high level of low-density lipoprotein cholesterol. Most cases of…”
Get full text

Induced pluripotent stem cell line ICGi037-A, obtained by reprogramming peripheral blood mononuclear cells from a patient with familial hypercholesterolemia due to heterozygous p.Trp443Arg mutations in LDLR by Zakharova, Irina S., Shevchenko, Alexander I., Tmoyan, Narek A., Elisaphenko, Eugeny A., Kalinin, Alexander P., Sleptcov, Aleksei A., Nazarenko, Maria S., Ezhov, Marat V., Kukharchuk, Valery V., Parfyonova, Yelena V., Zakian, Suren M.

“…Familial hypercholesterolemia (FH) is an autosomal dominant disorder increasing premature cardiovascular diseases risk due to atherosclerosis. Pathogenic…”
Get full text

Induced pluripotent stem cell line ICGi038-A, obtained by reprogramming peripheral blood mononuclear cells from a patient with familial hypercholesterolemia due to compound heterozygous c.1246C > T/c.940 + 3_940 + 6del mutations in LDLR by Zakharova, Irina S., Shevchenko, Alexander I., Tmoyan, Narek A., Elisaphenko, Eugeny A., Zubkova, Ekaterina S., Sleptcov, Aleksei A., Nazarenko, Maria S., Ezhov, Marat V., Kukharchuk, Valery V., Parfyonova, Yelena V., Zakian, Suren M.

“…The development of cellular models for familial hypercholesterolemia (FH) is an important direction for creating new approaches to atherosclerosis treatment…”
Get full text

Lipoprotein(a) level and apolipoprotein(a) phenotype as predictors of long-term cardiovascular outcomes after coronary artery bypass grafting by Ezhov, Marat V, Safarova, Maya S, Afanasieva, Olga I, Kukharchuk, Valery V, Pokrovsky, Sergei N

“…Abstract Objective To evaluate the relationships of lipoprotein(a) (Lp(a)) concentration and apolipoprotein(a) (apo(a)) phenotype to major adverse…”
Get full text

Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins by Lankin, Vadim Z, Tikhaze, Alla K, Kukharchuk, Valery V, Konovalova, Galina G, Pisarenko, Oleg I, Kaminnyi, Alexander I, Shumaev, Konstantin B, Belenkov, Yury N

“…The oxidative modification of low density lipoprotein (LDL) is thought to play an important role in atherogenesis. Drugs of beta-hydroxy-beta-methylglutaryl…”
Get full text

Identification of Patients at High Cardiovascular Risk by Igor V. Sergienko, PhD, ScD, Saule J. Urazalina, PhD, Valery V. Kukharchuk, PhD, ScD, Yuri A. Karpov, PhD, ScD, Sergey A. Boytsov, PhD, ScD

“…Objective: To identify individuals at high cardiovascular risk (CVR) to check for an additional estimate of CVR with the use of the ESH/ESC Guidelines (2003,…”
Get full text

Sialyltransferase activity of human plasma and aortic intima is enhanced in atherosclerosis by Gracheva, Elena V, Samovilova, Nelya N, Golovanova, Natalia K, Il’inskaya, Olga P, Tararak, Edward M, Malyshev, Peter P, Kukharchuk, Valery V, Prokazova, Nina V

“…Sialyltransferase activity has been determined in membrane preparations containing the Golgi apparatus that were isolated from atherosclerotic and normal human…”
Get full text

Calling and Phasing of Single-Nucleotide and Structural Variants of the ILDLR/I Gene Using Oxford Nanopore MinION by Nazarenko, Maria S, Sleptcov, Aleksei A, Zarubin, Aleksei A, Salakhov, Ramil R, Shevchenko, Alexander I, Tmoyan, Narek A, Elisaphenko, Eugeny A, Zubkova, Ekaterina S, Zheltysheva, Nina V, Ezhov, Marat V, Kukharchuk, Valery V, Parfyonova, Yelena V, Zakian, Suren M, Zakharova, Irina S

“…The LDLR locus has clinical significance for lipid metabolism, Mendelian familial hypercholesterolemia (FH), and common lipid metabolism-related diseases…”
Get full text

The Role of Red Yeast Rice Based Preparations for Non-Pharmacological Correction of Dyslipidemia in Patients with Low and Moderate Cardiovascular Risk (Expert Opinion) by Ezhov, M. V., Catapano, A., Escobar, C., Kukharchuk, V. V., Voevoda, M. I., Drapkina, O. M., Shalnova, S. A., Starodubova, A. V., Gurevich, V. S., Shaposhnik, I. I., Bolshakova, O. O., Oynotkinova, O. S., Alieva, A. S.

“…The Russian Federation is among countries with high cardiovascular risk. Hypercholesterolemia is a leading risk factor for the development of atherosclerotic…”
Get full text

C3a and C5a anaphylatoxins bind to heparin-based sorbent in low density lipoprotein apheresis: in vitro and in vivo investigations by Sinitsyn, V V, Bokchubaev, E T, Mamontova, A G, Ovtrakht, N V, Nasonov, E L, Konovalov, G A, Kukharchuk, V V

“…Plasmasorption on a heparin-based sorbent was performed in vitro. It demonstrated affinity of the C3a and C5a anaphylatoxins for the sorbent: C3a was removed…”
Get more information

Extracorporeal Methods in the Management of Severe and Malignant Arterial Hypertension by Arabidze, Gurami G, Kukharchuk, Valery V, Kutsenko, Anatoli I, Legkonogov, Alexander V, Zaruba, Alexander Yu

“…Novel approaches to managing refractory arterial hypertension (AH) have been tested in 130 patients ages 28 to 59 years with severe or malignant hypertension…”
Get full text

HMG-CoA inhibitors induced the LDL oxidation by Lankin, Vadim Z., Tikhaze, Alla K., Konovelova, Galina G., Kukharchuk, Valery V.

Get full text

Extracorporeal immunoadsorption for the specific removal of lipoprotein (a) (Lp(a) apheresis): preliminary clinical data by Pokrovsky, S N, Sussekov, A V, Afanasieva, O I, Adamova, I Y, Lyakishev, A A, Kukharchuk, V V

“…The extracorporeal procedure for the specific removal of lipoprotein (a) (Lp(a)) from human plasma--Lp(a) apheresis--was applied to the treatment of three…”
Get more information

Development of immunosorbents for apoB-containing lipoproteins apheresis by Pokrovsky, S N, Sussekov, A V, Adamova, I Y, Afanasieva, O I, Benevolenskaya, G F, Konovalov, G A, Kukharchuk, V V

“…Three types of sorbents were developed for the specific removal of atherogenic apoB-containing low-density lipoprotein (LDL) and lipoprotein LDL (a) (Lp[a])…”
Get more information