Search Results - "Kukhanova, M.K."

Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase by Yanvarev, D.V., Korovina, A.N., Usanov, N.N., Khomich, O.A., Vepsäläinen, J., Puljula, E., Kukhanova, M.K., Kochetkov, S.N.

“…Inorganic pyrophosphate (PPi) mimetics designed on a basis of methylenediphosphonic acid backbone are promising inhibitors of two key HIV replication enzymes,…”
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Human herpes simplex virus: Life cycle and development of inhibitors by Kukhanova, M. K., Korovina, A. N., Kochetkov, S. N.

“…WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes,…”
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Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity by Yanvarev, D.V., Korovina, A.N., Usanov, N.N., Khomich, O.A., Vepsäläinen, J., Puljula, E., Kukhanova, M.K., Kochetkov, S.N.

“…The structure-function analysis of 36 methylenebisphosphonates (BPs) as inhibitors of the phosphorolytic activity of native and drug-resistant forms of HIV-1…”
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Study of Antiherpetic Efficiency of Phosphite of Acycloguanosine Ableto Over come the Barrier of Resistance to Acyclovir by Andronova, V L, Jasko, M V, Kukhanova, M K, Galegov, G A, Skoblov, Yr S, Kochetkov, S N

“…As has been shown previously, phosphite of acycloguanosine (Hp-ACG) exhibits equal efficacy against ACV-sensitive and ACV-resistant HSV-1 strains in cell…”
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1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors by Deev, S.L., Yasko, M.V., Karpenko, I.L., Korovina, A.N., Khandazhinskaya, A.L., Andronova, V.L., Galegov, G.A., Shestakova, T.S., Ulomskii, E.N., Rusinov, V.L., Chupakhin, O.N., Kukhanova, M.K.

“…Structure of synthesized compounds. A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from…”
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Synthesis of thioamide bond catalyzed by E. coli ribosomes by Victorova, L.S., Kotusov, V.V., Azhaev, A.V., Krayevsky, A.A., Kukhanova, M.K., Gottikh, B.P.

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New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters by Kukhanova, M.K., Jasco, M.V., Shipitzyn, A.V., Yanvarev, D.V., Khandazhynskaya, A.L.

“…Abstract New phosphonate depot forms of AZT and 3TC were synthesized and their anti-HIV properties in cell systems, cellular uptake, intracellular…”
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2′, 3′-Dideoxy-3′ amlnonudeo 5′ .triphosphates are the terminators of DNA synthesis catalyzed by DNA polymerases by Chidgeavadze, Z.G., Beabealashvilli, R.Sh, Atrazhev, A.M., Kukhanova, M.K., Azhayev, A.V., Krayevsky, A.A.

“…It is shown that 2′,3′-dideoxy-3′-aminonucleoside 5′-tri-phosphates with adenine, guanine, cytosine and thymine bases are effective inhibitors of DNA…”
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Aminonucleosides and their derivatives. IVI Synthesis of the 3′-amino-3′-deoxynucleoside 5′-phosphates by Azhayev, A.V., Ozols, A.M., Bushnev, A.S., Dyatkina, N.B., Kochetkova, S.V., Victorova, L.S., Kukhanova, M.K., Krayevsky, A.A., Gottikh, B.P.

“…A new procedure hes been developed for the synthesis of 3′-amino-3′-deoxyribonucleosides of adenine, cytosine end uracil by condensing the trimethylsilylated…”
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Aminonucleosides and their derivatives. IV I Synthesis of the 3′-amino-3′-deoxynucleoside 5′-phosphates by Azhayev, A.V., Ozols, A.M., Bushnev, A.S., Dyatkina, N.B., Kochetkova, S.V., Victorova, L.S., Kukhanova, M.K., Krayevsky, A.A., Gottikh, B.P.

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Peptidyl transferase centre of bacterial ribosomes: substrate specificity and binding sites by Krayevsky, A.A., Kukhanova, M.K., Gottikh, B.P.

“…A detailed scheme of the Peptidyl Transferase Centre of bacterial ribosomes is proposed by summarizing the literature data on the substrate specificity of the…”
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Synthesis of an unnatural P-N bond catalyzed with Escherichia coli ribosomes by Tarussova, N.B., Jacovleva, G.M., Victorova, L.S., Kukhanova, M.K., Khomutov, R.M.

“…The formation of peptide bonds catalyzed by ribosomes has been studied using a number of 2'(3')-0-peptidyladenosine-5'-phosphates or analogs of tRNA. The…”
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Ribosomes of rat liver catalyze ‘minimal’ donor reaction by Kukhanova, M.K., Krayevsky, A.A., Gottikh, B.P., Stahl, J.

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Peptidyltransferase activity of 60S ribosomal subunit from wheat germ by Sikorski, M.M, Kukhanova, M.K, Krayevsky, A.A, Kegocki, A.B

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The study of the stimulating mechanism of the peptidyl donor activity of 2′(3′)- O-( N-formylmethionyl)-adenosine-5′-phosphate in peptidyl transferase of E. coli ribosome by Krayevsky, A.A., Victorova, L.S., Kotusov, V.V., Kukhanova, M.K., Treboganov, A.D., Tarussova, N.B., Gottikh, B.P.

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Thioacyl esters of nucleotides: synthesis of 3′(2′)-O-thiobenzoyl nucleoside 5′-phosphates by Azhayev, A.V., Krayevsky, A.A., Florentiev, V.L., Kukhanova, M.K., Gottikh, B.P.

“…The synthesis of 3′(2′)-0-thiobenzoyl nucleoside 5′-phosphates based on the condensation of N-(thiobenzoyl)-imidazole with nucleside 5′-phosphates was carried…”
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On the mechanism of peptide bond synthesis in the ribosome. 3′- O-phenylalanyl-2′- O-methyladenosine as a peptide acceptor by Pozdnyakov, V.A., Mitin, Yu.V., Kukhanova, M.K., Nikolaeva, L.V., Krayevsky, A.A., Gottikh, B.P.

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