Search Results - "Kukhanova, M. K"

Human herpes simplex virus: Life cycle and development of inhibitors by Kukhanova, M. K., Korovina, A. N., Kochetkov, S. N.

“…WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes,…”
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Anti-HIV nucleoside drugs: A retrospective view into the future by Kukhanova, M. K.

“…The review considers the design of antiretroviral drugs based on nucleoside analogs. Approximately 30 drugs have been approved for treating HIV-infected…”
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Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs by Korovina, A. N, Gus'kova, A. A, Skoblov, M. Yu, Andronova, V. L, Galegov, G. A, Kochetkov, S. N, Kukhanova, M. K, Skoblov, Yu. S

“…Primary structures of DNA polymerase (ul30) and thymidine kinase (ul23) genes from several herpes simplex virus type 1 (HSV-1) clinical isolates di ffering in…”
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Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity by Yanvarev, D.V., Korovina, A.N., Usanov, N.N., Khomich, O.A., Vepsäläinen, J., Puljula, E., Kukhanova, M.K., Kochetkov, S.N.

“…The structure-function analysis of 36 methylenebisphosphonates (BPs) as inhibitors of the phosphorolytic activity of native and drug-resistant forms of HIV-1…”
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Structural-functional relationships between terminal deoxynucleotidyltransferase and 5'-triphosphates of nucleoside analogs by Kukhanova, M K, Ivanov, A V, Jasko, M V

“…Substrate properties of nucleoside 5'-triphosphate (NTP) analogs, namely, 5'-triphosphates of L- and D-arabinonucleosides (D-FIAUTP, D-FMAUTP, and L-FMAUTP),…”
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Study of Antiherpetic Efficiency of Phosphite of Acycloguanosine Ableto Over come the Barrier of Resistance to Acyclovir by Andronova, V L, Jasko, M V, Kukhanova, M K, Galegov, G A, Skoblov, Yr S, Kochetkov, S N

“…As has been shown previously, phosphite of acycloguanosine (Hp-ACG) exhibits equal efficacy against ACV-sensitive and ACV-resistant HSV-1 strains in cell…”
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Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase by Yanvarev, D.V., Korovina, A.N., Usanov, N.N., Khomich, O.A., Vepsäläinen, J., Puljula, E., Kukhanova, M.K., Kochetkov, S.N.

“…Inorganic pyrophosphate (PPi) mimetics designed on a basis of methylenediphosphonic acid backbone are promising inhibitors of two key HIV replication enzymes,…”
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2′-Fluoronucleotides as substrates of viral replicative polymerases by Kukhanova, M. K., Korovina, A. N., Sharkin, Yu. A., Azhayev, A. V., Kochetkov, S. N.

“…Substrate specificities of three viral replicative polymerases of different origins (HIV reverse transcriptase, hepatitis C virus RNA polymerase, and herpes…”
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1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors by Deev, S.L., Yasko, M.V., Karpenko, I.L., Korovina, A.N., Khandazhinskaya, A.L., Andronova, V.L., Galegov, G.A., Shestakova, T.S., Ulomskii, E.N., Rusinov, V.L., Chupakhin, O.N., Kukhanova, M.K.

“…Structure of synthesized compounds. A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from…”
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Research of suppression of the herpes simplex virus reproduction with drug resistance by combination phosphite of acycloguanosine with some antiherpetic drugs by Andronova, V L, Jasko, M V, Kukhanova, M K, Skoblov, Yu S, Deryabin, P G, Galegov, G A

“…The activity of the phosphite of acycloguanosine (P-ACG) and six antivirals was tested individually and in double and triple combinations on two strains of the…”
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Enzymatic Synthesis of Bis(5′-Nucleosidyl) Tetra- and Triphosphates by Skoblov, A. Yu, Yas'ko, M. V., Murabuldaev, A. M., Kukhanova, M. K., Skoblov, Yu. S.

“…The total fraction of aminoacyl-tRNA synthases from Escherichia coli has been shown to catalyze the synthesis of the bis(5'-nucleosidyl) oligophosphates Ap…”
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Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors by Mukovnya, A. V., Tunitskaya, V. L., Khandazhinskaya, A. L., Golubeva, N. A., Zakirova, N. F., Ivanov, A. V., Kukhanova, M. K., Kochetkov, S. N.

“…A method has been developed for obtaining a full-length protein NS3 of hepatitis C virus with the yield of 6.5 mg/liter of cell culture, and conditions for…”
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Furano- and Pyrrolo [2,3-D] Pyrimidine Nucleosides and Their 5′-O-Triphospates: Synthesis and Enzymatic Activity by Alexandrova, L. A., Ivanov, M. A., Victorova, L. S., Kukhanova, M. K.

“…A series of bicyclic [2,3-d]furano- and pyrrolopyrimidine ribonucleosides were synthesized and converted chemically into corresponding 5′-O-triphosphates…”
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3'-C-Branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties by Fedorov, I. I, Kaz'mina, E. M, Novicov, N. A, Gurskaya, G. V, Bochkarev, A. V, Yas'ko, M. V, Viktorova, L. S, Kukhanova, M. K, Balzarini, Jan

“…A synthesis scheme for 3'-C-methyl-2'-deoxynucleosides and 3'-C-methylidene-2',3'-dideoxy-5-methyluridine has been proposed with 2-deoxyribose as the starting…”
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Analysis of mutations in DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs by Korovina, A N, Gus'kova, A A, Skoblov, M Iu, Andronova, V L, Galegov, G A, Kochetkov, S N, Kukhanova, M K, Skoblov, Iu S

“…The primary structures of DNA-polymerase (ul30) and thymidine kinase (ul23) genes from several herpes simplex virus type 1 (HSV-1) clinical isolates which…”
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Formation of phosphonester bonds catalyzed by DNA polymerase by Victorova, Lubov S., Dyatkina, Natalya B., Mozzherin, Dmitry Ju, Atrazhev, Alexey M., Krayevsky, Alexander A., Kukhanova, Marina K.

“…3′-Fluoro-2′,3′-dideoxythymidine 5′-(α-methylphos-phonyl)-β,γ- diphosphate and 2′-deoxythymidine-5′-(α-methylphosphonyl)-)β,γ diphosphate have been…”
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Aryl-Containing Esters Of Triphosphoric Acid As Substrates Of Terminal Deoxynucleotidyl Transferase by Khandazhinskaya, A. L., Matyugina, E. S., Alexandrova, L. A., Shirokova, E. A., Kukhanova, M. K., Jasko, M. V.

“…A new group of terminal deoxynucleotidyltransferase (TDT) substrates, namely, non-nucleoside triphosphates (NNTP) bearing 5-substituted 2,4-dinitrophenyl…”
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Structure-functional analysis of interactions of terminal deoxynucleotidyl transferase with new non-nucleoside substrates by Matyugina, E S, Alexandrova, L A, Jas'ko, M V, Ivanov, A V, Vasil'ev, I A, Lapteva, V L, Khandazhinskaya, A L, Kukhanova, M K

“…New non-nucleoside esters of phosphoric acid containing various hydrophobic groups, namely (1) N-(2-tripticencarbonyl)-4-aminobutyl; (2) 5-phenylsubstituted…”
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Hypophosphoric acid is a unique substrate of pyrophosphorolysis catalyzed by HIV-1 reverse transcriptase by Kukhanova, Marina K., Zakirova, Natalia F., Ivanov, Alexander V., Alexandrova, Ludmila A., Jasco, Maxim V., Khomutov, Alex R.

“…Pyrophosphate analogues, namely, pyrophosphorous, hypophosphoric, and hypophosphorous acids, were evaluated as inhibitors in elongation reactions and…”
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New depot forms of AZT and 3TC based on their phosphonate derivatives: anti-HIV activity and pharmacokinetic parameters by Kukhanova, M.K., Jasco, M.V., Shipitzyn, A.V., Yanvarev, D.V., Khandazhynskaya, A.L.

“…Abstract New phosphonate depot forms of AZT and 3TC were synthesized and their anti-HIV properties in cell systems, cellular uptake, intracellular…”
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