Search Results - "Kukes, V G"

Use of pharmacogenetic testing to prevent adverse drug reactions during statin therapy by Rumyantsev, N A, Kukes, V G, Kazakov, R E, Rumyantsev, A A, Sychev, D A

“…The number of patients receiving statins increases every year and due to the fact that they should take statins during their lives, the problem of their safety…”
Get full text

The Influence of Atorvastatin, Amlodipine and Ethoxidol on Ubiquinol and Ubiquinone Endogenous Plasma Concentrations in Patients with Chronic Heart Failure by Zozina, V I, Kondratenko, S N, Shikh, E V, Krasnykh, L M, Melnikov, E S, Kukes, V G

“…Coenzyme Q10 is a key component of the mitochondrial respiratory chain and a fat-soluble endogenous antioxidant performing many vital functions in the human…”
Get more information

Study of Antibacterial Drugs’ Nephrotoxicity in the RPTEC Cell Line by V. A. Evteev, I. S. Semenova, N. D. Bunyatyan, A. B. Prokofiev, V. G. Kukes

“…The created cell line of human proximal renal tubules RPTEC/TERT1 showed maximum compliance with primary human RPTEC, which makes it optimal for use in studies…”
Get full text

Experimental and Clinical Pharmacokinetics of Amitryptiline: Comparative Analysis by Kukes, V. G, Kondratenko, S. N, Savelyeva, M. I, Starodubtsev, A. K, Gneushev, E. T

“…Pharmacokinetics of two amitriptyline tablets, Amitryptiline Nycomed and Amitryptiline, was investigated clinically and experimentally after a single oral dose…”
Get full text

Quantitative Determination of Ubiquinone and Ubiquinol in Blood Plasma by HPLC with Mass-Spectrometric Detection by Krasnykh, L. M., Zozina, V. I., Mel’nikov, E. S., Goroshko, O. A., Rodina, T. A., Vasilenko, G. F., Kukes, V. G.

“…A method using HPLC with tandem mass spectrometry (HPLC-MS/MS) is proposed and validated for quantitative determination of ubiquinone and ubiquinol in human…”
Get full text

Quantitative Assay of B. pertussis Lipopolysaccharide by Nazirov, M. R., Poddubikov, A. V., Kukes, V. G., Sidorov, N. G., Parfenova, O. K.

“…We studied activity of Bordetella pertussis LPS in the LAL test. The mean activity of various series of LPS preparations obtained from B. pertussis cells…”
Get full text

Experimental and Clinical Pharmacokinetics of Fluoxetine and Amitriptyline: Comparative Analysis and Possible Methods of Extrapolation by Kondratenko, S. N., Savelyeva, M. I., Kukes, V. G., Shikh, E. V., Gneushev, E. T.

“…The pharmacokinetics of two fluoxetine capsulated dosage forms and two amitriptyline tablet forms after a single oral intake was studied in dogs and healthy…”
Get full text

Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia by Polyakov, A. V., Svistunov, A. A., Kondratenko, S. N., Kovachevich, I. V., Repenkova, L. G., Savelyeva, M. I., Kukes, V. G.

“…We studied pharmacokinetics and bioavailability of verapamil, propranolol, and ethacizine in healthy volunteers after single oral administration under normal…”
Get full text

OBITUARY FOR YURI N. CHERNOV 5 Nov 1937 – 1 Jan 2021 by Vasin, M. V., Esaulenko, I. E., Kukes, V. G., Petrov, V. I., Ushakov, I. B., Khokhlov, A. L.

“…On January 1, 2021, Yuri N.Chernov, Doctor of Sciences (Mediсine), Professor, Honored Doctor of the Russian Federation, Academician of the International Human…”
Get full text

The role of galectin-3 in the diagnosis and control of the effectiveness of pharmacotherapy of chronic heart failure by Giamdzhian, K. A, Kukes, V. G

“…Relevance. At present, it is urgent to develop new biomarkers that can serve as a tool for early diagnosis of the disease in order to select pharmacotherapy…”
Get full text

Myostatin - a modern understanding of the physiological role and significance in the development of age-associated diseases. by Gazdanova, A A, Kukes, V G, Parfenova, O K, Sidorov, N G, Perkov, A V, Solovieva, S A, Ryazantceva, O V, Lenkova, N I

“…Myostatin is a protein belonging to the myokine class, the family of transforming growth factors β (TGF-β). The review article, based on the analysis of…”
Get more information

Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative Stress by Goroshko, O. A., Krasnykh, L. M., Kukes, V. G., Zozina, V. I.

“…The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and…”
Get full text

Study of Genotoxic Properties of Thiosonide by Sаvchenko, A. Yu, Burenkov, M. S., Bаydin, P. S., Rаmenskаya, G. V., Perovа, N. V., Kukes, V. G.

“…The objective of the study: evaluation of mutagenic properties of thiosonide in tests of chromosomal aberrations in mammalian bone marrow cells and mutation…”
Get full text

CLINICAL VALUE OF DETERMINING GALECTIN-3 IN PATIENTS WITH CHRONIC HEART FAILURE by Gyamdzhyan, K. A., Kukes, V. G., Maksimov, M. L.

“…Relevance: today, the task of finding new biomarkers that could help monitor the effectiveness of pharmacotherapy, ensuring early diagnosis and predicting the…”
Get full text

Taurine modulates catalytic activity of cytochrome P450 3A4 by Shumyantseva, V. V., Makhova, A. A., Bulko, T. V., Bernhardt, R., Kuzikov, A. V., Shich, E. V., Kukes, V. G., Archakov, A. I.

“…The influence of the biologically active compound taurine on the stability and catalytic properties of the hemoprotein cytochrome P450 3A4 has been…”
Get full text

THE IMPACT OF CARDIOVASCULAR AND BRONCHOPULMONARY DISEASES ON COENZYME Q10 PLASMA CONCENTRATION by Zozina, V. I., Melnikov, E. S., Krasnykh, L. M., Goroshko, O. A., Kukes, V. G.

“…Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory…”
Get full text

The Mechanism of Action of Ethoxidol on Oxidative Stress Indices in Heart Failure and Hypotension by Kukes, V G, Parfenova, O K, Romanov, B K, Prokofiev, A B, Parfenova, E V, Sidorov, N G, Gazdanova, A A, Pavlova, L I, Zozina, V I, Andreev, A D, Aleksandrova, T V, Chernova, S V, Ramenskaya, G V

“…was to study the effect of 2-ethyl-6-methyl-3-hydroxypyridine malate (Ethoxidol) on the concentration of oxidative stress metabolites in patients with chronic…”
Get full text

The Mechanism of Action of Follistatin-like Protein-1 (FSTL-1) by Kukes, V. G., Olefir, Yu. V., Romanov, B. K., Prokofiev, A. B., Parfenova, E. V., Boldyreva, M. A., Goroshko, O. A., Parfenova, O. K., Gazdanova, A. A., Demchenkova, E. Yu

“…The paper provides current data on some proteins of the TGF- p family which are potentially capable of exerting a protective effect in diseases of the heart,…”
Get full text

Comparative Bioavailability of Tizanidine in Three Dosage Forms (6-MG Delayed-Release Tablets, Sirdalud Preparation, and 2-MG Tablets) by Kukes, V. G., Reikhart, D. V., Artnautov, V. S., Torshina, E. V., Kapashin, A. V., Belostotskii, A. V.

“…Valenta Pharm Co. compared the pharmacokinetic parameters in healthy volunteers of three prototype tizanidine dosage forms (delayed-release 6-mg tablets) and…”
Get full text

Treatment of hypertension in overweight patients by Kukes, V G, Anikin, G S, Andreevskaya, E M, Ashurkova, E A

“…The aim of the treatment of hypertension in patients with overweight is not only normalization of blood pressure, but also improvement of endothelial function,…”
Get full text