Search Results - "Kuk, Myeong Uk"

Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models by Kuk, Myeong Uk, Kim, Jae Won, Lee, Young-Sam, Cho, Kyung A, Park, Joon Tae, Park, Sang Chul

“…The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which…”
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Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence by Kuk, Myeong Uk, Lee, Haneur, Song, Eun Seon, Lee, Yun Haeng, Park, Ji Yun, Jeong, Subin, Kwon, Hyung Wook, Byun, Youngjoo, Park, Sang Chul, Park, Joon Tae

“…Senescence is a phenomenon defined by alterations in cellular organelles and is the primary cause of aging and aging-related diseases. Recent studies have…”
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Identification of Cellular Isoschaftoside-Mediated Anti-Senescence Mechanism in RAC2 and LINC00294 by Lee, Yun Haeng, So, Byeong Hyeon, Lee, Kyeong Seon, Kuk, Myeong Uk, Park, Ji Ho, Yoon, Jee Hee, Lee, Yoo Jin, Kim, Du Yeol, Kim, Min Seon, Kwon, Hyung Wook, Byun, Youngjoo, Lee, Ki Yong, Park, Joon Tae

“…As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing cellular damage. Flavonoids derived from natural products are known for…”
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Targeting Mitochondrial Oxidative Stress as a Strategy to Treat Aging and Age-Related Diseases by Lee, Yun Haeng, Kuk, Myeong Uk, So, Moon Kyoung, Song, Eun Seon, Lee, Haneur, Ahn, Soon Kil, Kwon, Hyung Wook, Park, Joon Tae, Park, Sang Chul

“…Mitochondria are one of the organelles undergoing rapid alteration during the senescence process. Senescent cells show an increase in mitochondrial size, which…”
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Cre/Lox-based RMCE for Site-specific Integration in CHO Cells by Kim, Jaewon, Lee, Yun Haeng, Kuk, Myeong Uk, Hwang, Su Young, Kwon, Hyung Wook, Park, Joon Tae

“…Traditional cell line development is based on random genomic integration of transgenes. Random integration leads to unpredictable expression and results in…”
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Improvement of Tol2 Transposon System Enabling Efficient Protein Production in CHO Cells by Hwang, Su Young, Lee, Yun Haeng, Kuk, Myeong Uk, Kim, Jae Won, Oh, Sekyung, Park, Joon Tae

“…Establishment of mammalian cell lines with high protein productivity is an important object in the field of biopharmaceutics. Toward this end, Tol2…”
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Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence by Lee, Yun Haeng, Park, Ji Yun, Lee, Haneur, Song, Eun Seon, Kuk, Myeong Uk, Joo, Junghyun, Oh, Sekyung, Kwon, Hyung Wook, Park, Joon Tae, Park, Sang Chul

“…Mitochondria are one of organelles that undergo significant changes associated with senescence. An increase in mitochondrial size is observed in senescent…”
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Rapid and Accurate Ecotoxicological Assessment of Heavy Metals Using Cyprinus carpio Cells by Lee, Yun Haeng, Kuk, Myeong Uk, Park, Ji Ho, Lee, Hojun, Lee, Haneur, So, Moon Kyoung, Yoon, Jee Hee, Lee, Yoo Jin, Kim, Duyeol, So, Byeonghyeon, Kim, Minseon, Park, Jihae, Han, Taejun, Park, Joon Tae

“…Heavy metals have serious negative effects on various aquatic organisms, and therefore rapid and accurate ecotoxicological assessments of heavy metals are…”
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Rapid and Efficient BAC Recombineering: Gain & Loss Screening System by Kuk, Myeong Uk, Lee, Yun Haeng, Kim, Jae Won, Hwang, Su Young, Park, Ji Yun, Song, Eun Seon, Kwon, Hyung Wook, Oh, Sekyung, Park, Joon Tae

“…Recombineering has been developed to modify bacterial artificial chromosome (BAC) via homologous recombination. Nevertheless, as a screening strategy to…”
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Potential Treatment of Lysosomal Storage Disease through Modulation of the Mitochondrial-Lysosomal Axis by Kuk, Myeong Uk, Lee, Yun Haeng, Kim, Jae Won, Hwang, Su Young, Park, Joon Tae, Park, Sang Chul

“…Lysosomal storage disease (LSD) is an inherited metabolic disorder caused by enzyme deficiency in lysosomes. Some treatments for LSD can slow progression, but…”
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Metabolic reprogramming as a novel therapeutic target for Coxsackievirus B3 by Kuk, Myeong Uk, Ga, Yun Ji, Kim, Ye Jin, Park, Ji Yun, Song, Eun Seon, Lee, Haneur, Lee, Yun Haeng, Ko, Gahyun, Kim, Jae Kwang, Yeh, Jung-Yong, Kwon, Hyung Wook, Byun, Youngjoo, Park, Joon Tae

“…Coxsackievirus B3 (CVB3) is a single-stranded RNA virus that belongs to the Enterovirus genus. CVB3 is a human pathogen associated with serious conditions such…”
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A novel hybrid promoter capable of continuously producing proteins in high yield by Lee, Haneur, Song, Eun Seon, Lee, Yun Haeng, Park, Ji Yun, Kuk, Myeong Uk, Kwon, Hyung Wook, Roh, Hyungmin, Park, Joon Tae

“…The establishment of cell lines with a high protein production is the most crucial objective in the field of biopharmaceuticals. To this end, efforts have been…”
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Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence by Kim, Jae Won, Kuk, Myeong Uk, Choy, Hyon E., Park, Sang Chul, Park, Joon Tae

“…Senescence is defined as irreversible cell cycle arrest and constitutes a major driving force in diseases related to aging or premature aging. Recent studies…”
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Targeting regulation of ATP synthase 5 alpha/beta dimerization alleviates senescence by Lee, Yun Haeng, Choi, Doyoung, Jang, Geonhee, Park, Ji Yun, Song, Eun Seon, Lee, Haneur, Kuk, Myeong Uk, Joo, Junghyun, Ahn, Soon Kil, Byun, Youngjoo, Park, Joon Tae

“…Senescence is a distinct set of changes in the senescence-associated secretory phenotype (SASP) and leads to aging and age-related diseases. Here, we screened…”
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Polyporus ulleungus mycelia cultured in MEB medium produce metabolites with anticancer property by Lee, Yun Haeng, Kuk, Myeong Uk, So, Moon Kyoung, Park, Hyon Jin, Song, Eun Seon, Park, Jiho, Yoon, Jee Hee, Kwon, Hyung Wook, Choi, Jaehyuk, Park, Joon Tae

“…Cancer cells are characterized by apoptosis evasion and uncontrolled cell cycle progression. To combat these characteristics, efforts have been made to find…”
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ROSA26 BAC-based system enables continuous high-yield protein production by Kuk, Myeong Uk, So, Moon Kyoung, Park, Ji Ho, Yoon, Jee Hee, Lee, Yoo Jin, Kim, Duyeol, So, Byeonghyeon, Lee, Yun Haeng, Kim, Minseon, Byun, Youngjoo, Kwon, Hyung Wook, Park, Joon Tae

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Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models by Kuk, Myeong Uk, Kim, Jae Won, Lee, Young-Sam, Cho, Kyung A, Park, Joon Tae, Park, Sang Chul

“…The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which…”
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ATM mediated-p53 signaling pathway forms a novel axis for senescence control by Hwang, Su Young, Kuk, Myeong Uk, Kim, Jae Won, Lee, Yun Haeng, Lee, Young-Sam, Choy, Hyon E., Park, Sang Chul, Park, Joon Tae

“…•ATM inhibition yields senescence amelioration through a p53-dependent manner.•The restorative effect was also afforded by direct p53 inhibition via a chemical…”
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Improvement of Tol2 Transposon System by Modification of Tol2 Transposase by Park, Ji Yun, Lee, Haneur, Song, Eun Seon, Lee, Yun Haeng, Kuk, Myeong Uk, Ko, Gahyun, Byun, Youngjoo, Kwon, Hyung Wook, Park, Joon Tae

“…Tol2 transposon-based vector platform has been developed as a useful strategy to improve protein yield. Tol2 transposase identifies inverted terminal repeats…”
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Improvement of Sleeping Beauty Transposon System Enabling Efficient and Stable Protein Production by Lee, Yun Haeng, Park, Ji Yun, Song, Eun Seon, Lee, Haneur, Kuk, Myeong Uk, Joo, Junghyun, Roh, Hyungmin, Park, Joon Tae

“…The most essential goal in the field of biopharmaceuticals is to develop cell lines with higher protein yields. To this goal, the Sleeping Beauty (SB)…”
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