Search Results - "Kuiper, Emily G."

The RNA exosome and RNA exosome-linked disease by Morton, Derrick J, Kuiper, Emily G, Jones, Stephanie K, Leung, Sara W, Corbett, Anita H, Fasken, Milo B

“…The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that…”
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Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate by Hudson, William H., Pickard, Mark R., de Vera, Ian Mitchelle S., Kuiper, Emily G., Mourtada-Maarabouni, Mirna, Conn, Graeme L., Kojetin, Douglas J., Williams, Gwyn T., Ortlund, Eric A.

“…The majority of the eukaryotic genome is transcribed, generating a significant number of long intergenic noncoding RNAs (lincRNAs). Although lincRNAs represent…”
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Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii by Hudson, Lauren E, Fasken, Milo B, McDermott, Courtney D, McBride, Shonna M, Kuiper, Emily G, Guiliano, David B, Corbett, Anita H, Lamb, Tracey J

“…Recent studies have suggested the potential of probiotic organisms to be adapted for the synthesis and delivery of oral therapeutics. The probiotic yeast…”
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50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA by Laughlin, Zane T, Nandi, Suparno, Dey, Debayan, Zelinskaya, Natalia, Witek, Marta A, Srinivas, Pooja, Nguyen, Ha An, Kuiper, Emily G, Comstock, Lindsay R, Dunham, Christine M, Conn, Graeme L

“…Changes in bacterial ribosomal RNA (rRNA) methylation status can alter the activity of diverse groups of ribosome-targeting antibiotics. These modifications…”
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tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10 by Strassler, Sarah E., Bowles, Isobel E., Krishnamohan, Aiswarya, Kim, Hyejeong, Edgington, Catherine B., Kuiper, Emily G., Hancock, Clio J., Comstock, Lindsay R., Jackman, Jane E., Conn, Graeme L.

“…The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the ninth nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya…”
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A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis by Witek, Marta A., Kuiper, Emily G., Minten, Elizabeth, Crispell, Emily K., Conn, Graeme L.

“…Capreomycin is a potent ribosome-targeting antibiotic that is an essential component of current antituberculosis treatments, particularly in the case of…”
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Substrate recognition by the Pseudomonas aeruginosa EF-Tu–modifying methyltransferase EftM by Kuiper, Emily G., Dey, Debayan, LaMore, Paige A., Owings, Joshua P., Prezioso, Samantha M., Goldberg, Joanna B., Conn, Graeme L.

“…The opportunistic bacterial pathogen Pseudomonas aeruginosa is a leading cause of serious infections in individuals with cystic fibrosis, compromised immune…”
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Binding Induced RNA Conformational Changes Control Substrate Recognition and Catalysis by the Thiostrepton Resistance Methyltransferase (Tsr) by Kuiper, Emily G., Conn, Graeme L.

“…Ribosomal RNA (rRNA) post-transcriptional modifications are essential for ribosome maturation, translational fidelity, and are one mechanism used by both…”
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The RNA Exosome and Human Disease by Fasken, Milo B, Morton, Derrick J, Kuiper, Emily G, Jones, Stephanie K, Leung, Sara W, Corbett, Anita H

“…The evolutionarily conserved RNA exosome is a multisubunit ribonuclease complex that processes and/or degrades numerous RNAs. Recently, mutations in genes…”
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Trimethylation of Elongation Factor-Tu by the Dual Thermoregulated Methyltransferase EftM Does Not Impact Its Canonical Function in Translation by Prezioso, Samantha M., Duong, Duc M., Kuiper, Emily G., Deng, Qiudong, Albertí, Sebastián, Conn, Graeme L., Goldberg, Joanna B.

“…The Pseudomonas aeruginosa methyltransferase EftM trimethylates elongation factor-Tu (EF-Tu) on lysine 5 to form a post-translational modification important…”
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Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase by Owings, Joshua P., Kuiper, Emily G., Prezioso, Samantha M., Meisner, Jeffrey, Varga, John J., Zelinskaya, Natalia, Dammer, Eric B., Duong, Duc M., Seyfried, Nicholas T., Albertí, Sebastián, Conn, Graeme L., Goldberg, Joanna B.

“…Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that trimethylates elongation factor-thermo-unstable (EF-Tu) on lysine 5. Lysine 5 methylation…”
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Functional roles in S-adenosyl-l-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase by Myers, Cullen L., Kuiper, Emily G., Grant, Pei C., Hernandez, Jennifer, Conn, Graeme L., Honek, John F.

“…•Tsr exhibits equivalent SAM binding at two structurally non-equivalent sites.•An arginine residue is implicated in the Tsr catalytic mechanism.•A central…”
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Identification of SUMO modification sites in the base excision repair protein, Ntg1 by Swartzlander, Daniel B., McPherson, Annie J., Powers, Harry R., Limpose, Kristin L., Kuiper, Emily G., Degtyareva, Natalya P., Corbett, Anita H., Doetsch, Paul W.

“…•Base excision repair (BER) proteins can be modified by SUMO.•Both S. cerevisiae Ntg1 and human NTHL1 can be sumoylated.•Five lysines are identified as the…”
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Molecular regulation of lysine trimethylation by the P. aeruginosa methyltransferase EftM by Dey, Debayan, Kuiper, Emily G, Goldberg, Joanna B, Conn, Graeme L

“…Pseudomonas aeruginosa is an opportunistic pathogen and a leading cause of severe life‐threatening lung and other infections in individuals with cystic…”
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Abstract 1531: A bispecific chimeric-antigen receptor T-cell factory for triple-negative breast cancer by Kuiper, Emily G., Chan, Leo L., Chang, Matthew R., Zhu, Quan K., Marasco, Wayne A.

“…Abstract Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with poor clinical prognosis. While treated with chemotherapies,…”
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tRNA m 1 G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10 by Strassler, Sarah E, Bowles, Isobel E, Krishnamohan, Aiswarya, Kim, Hyejeong, Edgington, Catherine B, Kuiper, Emily G, Hancock, Clio J, Comstock, Lindsay R, Jackman, Jane E, Conn, Graeme L

“…The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the ninth nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya…”
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Functional roles inS‐adenosyl‐l‐methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase by Myers, Cullen L., Kuiper, Emily G., Grant, Pei C., Hernandez, Jennifer, Conn, Graeme L., Honek, John F.

“…Resistance to the antibiotic thiostrepton, in producingStreptomycetes, is conferred by theS‐adenosyl‐l‐methionine (SAM)‐dependent SPOUT methyltransferase Tsr…”
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Functional Heterologous Protein Expression by Genetically Engineered Probiotic Yeast Saccharomyces boulardii: e112660 by Hudson, Lauren E, Fasken, Milo B, McDermott, Courtney D, McBride, Shonna M, Kuiper, Emily G, Guiliano, David B, Corbett, Anita H, Lamb, Tracey J

“…Recent studies have suggested the potential of probiotic organisms to be adapted for the synthesis and delivery of oral therapeutics. The probiotic yeast…”
Get full text