Search Results - "Kuiper, E F E"

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks by Meister-Broekema, Melanie, Freilich, Rebecca, Jagadeesan, Chandhuru, Rauch, Jennifer N., Bengoechea, Rocio, Motley, William W., Kuiper, E. F. Elsiena, Minoia, Melania, Furtado, Gabriel V., van Waarde, Maria A. W. H., Bird, Shawn J., Rebelo, Adriana, Zuchner, Stephan, Pytel, Peter, Scherer, Steven S., Morelli, Federica F., Carra, Serena, Weihl, Conrad C., Bergink, Steven, Gestwicki, Jason E., Kampinga, Harm H.

“…BAG3 is a multi-domain hub that connects two classes of chaperones, small heat shock proteins (sHSPs) via two isoleucine-proline-valine (IPV) motifs and Hsp70…”
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Coordinating nucleoporin condensation and nuclear pore complex assembly by Kuiper, E. F. Elsiena, Prophet, Sarah M., Schlieker, Christian

“…The nuclear pore complex (NPC) is among the most elaborate protein complexes in eukaryotes. While ribosomes and proteasomes are known to require dedicated…”
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The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis by Kuiper, E. F. Elsiena, Gallardo, Paola, Bergsma, Tessa, Mari, Muriel, Kolbe Musskopf, Maiara, Kuipers, Jeroen, Giepmans, Ben N. G., Steen, Anton, Kampinga, Harm H., Veenhoff, Liesbeth M., Bergink, Steven

“…Biogenesis of nuclear pore complexes (NPCs) includes the formation of the permeability barrier composed of phenylalanine-glycine-rich nucleoporins (FG-Nups)…”
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Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G by Kakkar, Vaishali, Kuiper, E. F. Elsiena, Pandey, Abhinav, Braakman, Ineke, Kampinga, Harm H.

“…Parkinson’s disease is one of the most common neurodegenerative disorders and several mutations in different genes have been identified to contribute to the…”
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FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation by Furtado, Gabriel Vasata, Yang, Jing, Wu, Di, Papagiannopoulos, Christos I, Terpstra, Hanna M, Kuiper, E F Elsiena, Krauss, Sybille, Zhu, Wei-Guo, Kampinga, Harm H, Bergink, Steven

“…Abstract FOXO1, a transcription factor downstream of the insulin/insulin like growth factor axis, has been linked to protein degradation. Elevated expression…”
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Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch by Kuiper, E F E, de Mattos, Eduardo P, Jardim, Laura B, Kampinga, Harm H, Bergink, Steven

“…Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to inherited neuronal dysfunction and degeneration. The expansion size in all…”
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KCa2 and KCa3 Channels in Learning and Memory Processes, and Neurodegeneration by Kuiper, Els F. E., Nelemans, Ad, Luiten, Paul, Nijholt, Ingrid, Dolga, Amalia, Eisel, Uli

“…Calcium-activated potassium (K Ca ) channels are present throughout the central nervous system as well as many peripheral tissues. Activation of K Ca channels…”
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K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration by Kuiper, Els F E, Nelemans, Ad, Luiten, Paul, Nijholt, Ingrid, Dolga, Amalia, Eisel, Uli

“…Calcium-activated potassium (K(Ca)) channels are present throughout the central nervous system as well as many peripheral tissues. Activation of K(Ca) channels…”
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