Search Results - "Kuijpers, Marijke J.E"

Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen by Kuijpers, Marijke J.E, de Witt, Susanne, Nergiz-Unal, Reyhan, van Kruchten, Roger, Korporaal, Suzanne J.A, Verhamme, Peter, Febbraio, Maria, Tjwa, Marc, Voshol, Peter J, Hoylaerts, Marc F, Cosemans, Judith M.E.M, Heemskerk, Johan W.M

“…OBJECTIVE—Platelets abundantly express the membrane receptor CD36 and store its ligand thrombospondin-1 (TSP1) in the α-granules. We investigated whether…”
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Factor XI Regulates Pathological Thrombus Formation on Acutely Ruptured Atherosclerotic Plaques by van Montfoort, Maurits L, Kuijpers, Marijke J.E, Knaup, Véronique L, Bhanot, Sanjay, Monia, Brett P, Roelofs, Joris J.T.H, Heemskerk, Johan W.M, Meijers, Joost C.M

“…OBJECTIVE—Coagulation factor XI is proposed as therapeutic target for anticoagulation. However, it is still unclear whether the antithrombotic properties of…”
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Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors by Nergiz-Ünal, Reyhan, Kuijpers, Marijke J.E, de Witt, Susanne M, Heeneman, Sylvia, Feijge, Marion A.H, Garcia Caraballo, Sonia C, Biessen, Erik A.L, Haenen, Guido R.M.M, Cosemans, Judith M.E.M, Heemskerk, Johan W.M

“…Abstract Introduction Consumption of n -3 polyunsaturated fatty acids (PUFA) and antioxidant polyphenols is considered to decline the risk of cardiovascular…”
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The Glycoprotein VI-Phospholipase Cγ2 Signaling Pathway Controls Thrombus Formation Induced by Collagen and Tissue Factor In Vitro and In Vivo by Munnix, Imke C.A, Strehl, Amrei, Kuijpers, Marijke J.E, Auger, Jocelyn M, van der Meijden, Paola E.J, van Zandvoort, Marc A.M, oude Egbrink, Mirjam G.A, Nieswandt, Bernhard, Heemskerk, Johan W.M

“…OBJECTIVE—Both collagen and tissue factor can be initiating factors in thrombus formation. We investigated the signaling pathway of collagen-induced platelet…”
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Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes by Gerdes, Norbert, Seijkens, Tom, Lievens, Dirk, Kuijpers, Marijke J.E, Winkels, Holger, Projahn, Delia, Hartwig, Helene, Beckers, Linda, Megens, Remco T.A, Boon, Louis, Noelle, Randolph J, Soehnlein, Oliver, Heemskerk, Johan W.M, Weber, Christian, Lutgens, Esther

“…OBJECTIVE—Beyond their eminent role in hemostasis and thrombosis, platelets are recognized as mediators of inflammation. Platelet cluster of differentiation 40…”
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Platelet Collagen Receptors and Coagulation. A Characteristic Platelet Response as Possible Target for Antithrombotic Treatment by Heemskerk, Johan W.M., Kuijpers, Marijke J.E., Munnix, Imke C.A., Siljander, Pia R.M.

“…Collagen is a unique agonist of platelets, because it acts as an immobilized ligand that only causes platelet activation after stable adhesion. This review…”
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Age- and gender-matched controls needed for platelet-based biomarker studies by Sabrkhany, Siamack, Kuijpers, Marijke J E, Van Kuijk, Sander M J, Griffioen, Arjan W, Oude Egbrink, Mirjam G A

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A combination of platelet features allows detection of early-stage cancer by Sabrkhany, Siamack, Kuijpers, Marijke J.E, van Kuijk, Sander M.J, Sanders, Linda, Pineda, Sharo, Olde Damink, Steven W.M, Dingemans, Anne-Marie C, Griffioen, Arjan W, oude Egbrink, Mirjam G.A

“…Abstract Background Detection of early-stage cancer significantly improves patient survival. As platelets play an important role in cancer progression, we…”
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Factor XII Regulates the Pathological Process of Thrombus Formation on Ruptured Plaques by Kuijpers, Marijke J.E, van der Meijden, Paola E.J, Feijge, Marion A.H, Mattheij, Nadine J.A, May, Frauke, Govers-Riemslag, José, Meijers, Joost C.M, Heemskerk, Johan W.M, Renné, Thomas, Cosemans, Judith M.E.M

“…OBJECTIVE—Atherothrombosis is the main cause of myocardial infarction and ischemic stroke. Although the extrinsic (tissue factor–factor VIIa [FVIIa]) pathway…”
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Native, Intact Glucagon-Like Peptide 1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions by Sternkopf, Marieke, Nagy, Magdolna, Baaten, Constance C.F.M.J., Kuijpers, Marijke J.E., Tullemans, Bibian M.E., Wirth, Julia, Theelen, Wendy, Mastenbroek, Tom G., Lehrke, Michael, Winnerling, Benjamin, Baerts, Lesley, Marx, Nikolaus, De Meester, Ingrid, Döring, Yvonne, Cosemans, Judith M.E.M., Daiber, Andreas, Steven, Sebastian, Jankowski, Joachim, Heemskerk, Johan W.M., Noels, Heidi

“…OBJECTIVE:In patients with diabetes mellitus, increased platelet reactivity predicts cardiac events. Limited evidence suggests that DPP-4 (dipeptidyl peptidase…”
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Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces by Jooss, Natalie J, De Simone, Ilaria, Provenzale, Isabella, Fernández, Delia I, Brouns, Sanne L N, Farndale, Richard W, Henskens, Yvonne M C, Kuijpers, Marijke J E, Ten Cate, Hugo, van der Meijden, Paola E J, Cavill, Rachel, Heemskerk, Johan W M

“…Platelet interaction with collagens, via von Willebrand factor, is a potent trigger of shear-dependent thrombus formation mediated by subsequent engagement of…”
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Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation by Gilio, Karen, van Kruchten, Roger, Braun, Attila, Berna-Erro, Alejandro, Feijge, Marion A.H., Stegner, David, van der Meijden, Paola E.J., Kuijpers, Marijke J.E., Varga-Szabo, David, Heemskerk, Johan W.M., Nieswandt, Bernhard

“…In platelets, STIM1 has been recognized as the key regulatory protein in store-operated Ca2+ entry (SOCE) with Orai1 as principal Ca2+ entry channel. Both…”
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Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α by Kuijpers, Marijke J.E, Mattheij, Nadine J.A, Cipolla, Lina, van Geffen, Johanna P, Lawrence, Toby, Donners, Marjo M.P.C, Boon, Louis, Lievens, Dirk, Torti, Mauro, Noels, Heidi, Gerdes, Norbert, Cosemans, Judith M.E.M, Lutgens, Esther, Heemskerk, Johan W.M

“…OBJECTIVE—To investigate the roles and signaling pathways of CD40L and CD40 in platelet–platelet interactions and thrombus formation under conditions relevant…”
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Sunitinib uptake inhibits platelet function in cancer patients by Sabrkhany, Siamack, Griffioen, Arjan W, Pineda, Sharo, Sanders, Linda, Mattheij, Nadine, van Geffen, Johanna P, Aarts, Maureen J, Heemskerk, Johan W.M, oude Egbrink, Mirjam G.A, Kuijpers, Marijke J.E

“…Abstract Background Sunitinib is an oral tyrosine kinase inhibitor used for cancer treatment. Patients treated with sunitinib are at higher bleeding risk. As…”
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Segregation of Platelet Aggregatory and Procoagulant Microdomains in Thrombus Formation: Regulation by Transient Integrin Activation by Munnix, Imke C.A, Kuijpers, Marijke J.E, Auger, Jocelyn, Thomassen, Christella M.L.G.D, Panizzi, Peter, van Zandvoort, Marc A.M, Rosing, Jan, Bock, Paul E, Watson, Steve P, Heemskerk, Johan W.M

“…OBJECTIVE—Platelets play a dual role in thrombosis by forming aggregates and stimulating coagulation. We investigated the commitment of platelets to these…”
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Targeting platelet receptor function in thrombus formation: The risk of bleeding by Swieringa, Frauke, Kuijpers, Marijke J.E, Heemskerk, Johan W.M, van der Meijden, Paola E.J

“…Abstract In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis…”
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Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation by Fernández, Delia I., Provenzale, Isabella, Cheung, Hilaire Y.F., van Groningen, Jan, Tullemans, Bibian M.E., Veninga, Alicia, Dunster, Joanne L., Honarnejad, Saman, van den Hurk, Helma, Kuijpers, Marijke J.E., Heemskerk, Johan W.M.

“…Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding…”
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Principal Role of Glycoprotein VI in α2β1 and αIIbβ3 Activation During Collagen-Induced Thrombus Formation by Lecut, Christelle, Schoolmeester, Anne, Kuijpers, Marijke J.E, Broers, Jos L.V, van Zandvoort, Marc A.M.J, Vanhoorelbeke, Karen, Deckmyn, Hans, Jandrot-Perrus, Martine, Heemskerk, Johan W.M

“…OBJECTIVE—High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of α2β1…”
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Dual Role of Platelet Protein Kinase C in Thrombus Formation: STIMULATION OF PRO-AGGREGATORY AND SUPPRESSION OF PROCOAGULANT ACTIVITY IN PLATELETS by Strehl, Amrei, Munnix, Imke C.A, Kuijpers, Marijke J.E, van der Meijden, Paola E.J, Cosemans, Judith M.E.M, Feijge, Marion A.H, Nieswandt, Bernhard, Heemskerk, Johan W.M

“…Protein kinase C (PKC) isoforms regulate many platelet responses in a still incompletely understood manner. Here we investigated the roles of PKC in the…”
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Imaging Collagen in Intact Viable Healthy and Atherosclerotic Arteries Using Fluorescently Labeled CNA35 and Two-Photon Laser Scanning Microscopy by Megens, Remco T.A., Egbrink, Mirjam G.A. oude, Cleutjens, Jack P.M., Kuijpers, Marijke J.E., Schiffers, Paul H.M., Merkx, Maarten, Slaaf, Dick W., van Zandvoort, Marc A.M.J.

“…We evaluated CNA35 as a collagen marker in healthy and atherosclerotic arteries of mice after both ex vivo and in vivo administration and as a molecular…”
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