Search Results - "Kuhnert, Lydia"

AhR-activating pesticides increase the bovine ABCG2 efflux activity in MDCKII-bABCG2 cells by Kuhnert, Lydia, Giantin, Mery, Dacasto, Mauro, Halwachs, Sandra, Honscha, Walther

“…In bovine mammary glands, the ABCG2 transporter actively secretes xenobiotics into dairy milk. This can have significant implications when cattle are exposed…”
Get full text

Enhanced reversal of ABCG2‐mediated drug resistance by replacing a phenyl ring in baicalein with a meta‐carborane by Kuhnert, Lydia, Kuhnert, Robert, Sárosi, Menyhárt B., Lakoma, Cathleen, Scholz, Birte K., Lönnecke, Peter, Hey‐Hawkins, Evamarie, Honscha, Walther

“…Success of chemotherapy is often hampered by multidrug resistance. One mechanism for drug resistance is the elimination of anticancer drugs through drug…”
Get full text

Carborane-Based ABCG2-Inhibitors Sensitize ABC-(Over)Expressing Cancer Cell Lines for Doxorubicin and Cisplatin by Paskas, Svetlana, Stockmann, Philipp, Mijatović, Sanja, Kuhnert, Lydia, Honscha, Walther, Hey-Hawkins, Evamarie, Maksimović-Ivanić, Danijela

“…The ABCG2 transporter protein, as part of several known mechanisms involved in multidrug resistance, has the ability to transport a broad spectrum of…”
Get full text

The More the Better-Investigation of Polymethoxylated N -Carboranyl Quinazolines as Novel Hybrid Breast Cancer Resistance Protein Inhibitors by Stockmann, Philipp, Kuhnert, Lydia, Leinung, Wencke, Lakoma, Cathleen, Scholz, Birte, Paskas, Svetlana, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Honscha, Walther, Hey-Hawkins, Evamarie

“…The ineffectiveness and failing of chemotherapeutic treatments are often associated with multidrug resistance (MDR). MDR is primarily linked to the…”
Get full text

2‐Carboranylquinazoline: The Path to an ABCG2 Inhibitor by Stockmann, Philipp, Kuhnert, Lydia, Zörner, Lisa, Honscha, Walther, Hey‐Hawkins, Evamarie

“…The role of ATP‐binding cassette (ABC) transporter‐mediated multidrug resistance (MDR) in anti‐cancer therapy is often challenging, frequently leading to…”
Get full text

Carboranes as Potent Phenyl Mimetics: A Comparative Study on the Reversal of ABCG2‐Mediated Drug Resistance by Carboranylquinazolines and Their Organic Isosteres by Stockmann, Philipp, Kuhnert, Lydia, Krajnović, Tamara, Mijatović, Sanja, Maksimović‐Ivanić, Danijela, Honscha, Walther, Hey‐Hawkins, Evamarie

“…Multidrug resistance is a major challenge in clinical cancer therapy. In particular, overexpression of certain ATP‐binding cassette (ABC) transporter proteins,…”
Get full text

Borcalein: a Carborane‐Based Analogue of Baicalein with 12‐Lipoxygenase‐Independent Toxicity by Kuhnert, Robert, Kuhnert, Lydia, Sárosi, Menyhárt‐B., George, Sven, Draca, Dijana, Paskas, Svetlana, Hofmann, Bettina, Steinhilber, Dieter, Honscha, Walther, Mijatović, Sanja, Maksimović‐Ivanić, Danijela, Hey‐Hawkins, Evamarie

“…12‐Lipoxygenase is crucial for tumour angiogenesis. 5,6,7‐Trihydroxy‐2‐phenyl‐4H‐1‐benzopyran‐4‐one (baicalein) is a suitable inhibitor for this enzyme but is…”
Get full text