Search Results - "Kuhnel, Brigitte"
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1
Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs
Published in Clinical epigenetics (01-12-2021)“…Non-coding RNA 886 (nc886) is coded from a maternally inherited metastable epiallele. We set out to investigate the determinants and dynamics of the…”
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2
Tobacco smoking leads to extensive genome-wide changes in DNA methylation
Published in PloS one (17-05-2013)“…Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in…”
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3
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
Published in Nature communications (14-05-2021)“…Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is…”
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4
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
Published in Nature communications (03-01-2020)“…DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain…”
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5
Are Epigenetic Factors Implicated in Chronic Widespread Pain?
Published in PloS one (10-11-2016)“…Chronic widespread musculoskeletal pain (CWP) is the cardinal symptom of fibromyalgia and affects about 12% of the general population. Familial aggregation of…”
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6
DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies
Published in JAMA psychiatry (Chicago, Ill.) (01-09-2018)“…Depressive disorders arise from a combination of genetic and environmental risk factors. Epigenetic disruption provides a plausible mechanism through which…”
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7
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
Published in Nature genetics (01-11-2009)“…Measurements of erythrocytes within the blood are important clinical traits and can indicate various hematological disorders. We report here genome-wide…”
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8
Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models
Published in Genetics (Austin) (01-04-2019)“…In humans, most genome-wide association studies have been conducted using data from Caucasians and many of the reported findings have not replicated in other…”
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Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
Published in Nature genetics (01-01-2022)“…We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify…”
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An Integrated Epigenetic and Transcriptomic Analysis Reveals Distinct Tissue-Specific Patterns of DNA Methylation Associated with Atopic Dermatitis
Published in Journal of investigative dermatology (01-07-2014)“…Epigenetic alterations are increasingly recognized as mechanisms for disease-associated changes in genome function and important risk factors for complex…”
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11
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Published in Diabetes (New York, N.Y.) (01-12-2010)“…OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors…”
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12
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Published in Nature genetics (01-11-2009)“…Nicole Soranzo and colleagues report a meta-analysis of genome-wide association datasets identifying 22 associations to 8 clinically relevant hematological…”
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13
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning
Published in PLoS computational biology (01-02-2020)“…Genome-wide association studies (GWAS) identify genetic variants associated with traits or diseases. GWAS never directly link variants to regulatory…”
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14
Multiple Loci Are Associated with White Blood Cell Phenotypes: e1002113
Published in PLoS genetics (01-06-2011)“…White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and…”
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15
Circulating metabolites modulated by diet are associated with depression
Published in Molecular psychiatry (01-09-2023)“…Metabolome reflects the interplay of genome and exposome at molecular level and thus can provide deep insights into the pathogenesis of a complex disease like…”
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Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9
Published in Thyroid (New York, N.Y.) (01-03-2023)“…Thyroid hormones play a key role in differentiation and metabolism and are known regulators of gene expression through both genomic and epigenetic processes…”
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17
Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits
Published in Clinical epigenetics (22-10-2020)“…Tobacco smoking is a well-known modifiable risk factor for many chronic diseases, including cardiovascular disease (CVD). One of the proposed underlying…”
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18
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci
Published in Molecular psychiatry (05-05-2020)“…Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To…”
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A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function
Published in Blood (16-04-2009)“…Mean platelet volume (MPV) and platelet count (PLT) are highly heritable and tightly regulated traits. We performed a genome-wide association study for MPV and…”
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20
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Published in Nature communications (01-12-2019)“…Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects…”
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