Search Results - "Kuhn Donald M."

Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice by Angoa-Pérez, Mariana, Zagorac, Branislava, Winters, Andrew D, Greenberg, Jonathan M, Ahmad, Madison, Theis, Kevin R, Kuhn, Donald M

“…The list of pharmacological agents that can modify the gut microbiome or be modified by it continues to grow at a high rate. The greatest amount of attention…”
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Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism by Kane, Michael J, Angoa-Peréz, Mariana, Briggs, Denise I, Sykes, Catherine E, Francescutti, Dina M, Rosenberg, David R, Kuhn, Donald M

“…Autism is a complex neurodevelopmental disorder characterized by impaired reciprocal social interaction, communication deficits and repetitive behaviors. A…”
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Assessing the role of dopamine in the differential neurotoxicity patterns of methamphetamine, mephedrone, methcathinone and 4-methylmethamphetamine by Anneken, John H., Angoa-Perez, Mariana, Sati, Girish C., Crich, David, Kuhn, Donald M.

“…Methamphetamine and mephedrone are designer drugs with high abuse liability and they share extensive similarities in their chemical structures and…”
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Cocaine hydrochloride, cocaine methiodide and methylenedioxypyrovalerone (MDPV) cause distinct alterations in the structure and composition of the gut microbiota by Angoa-Pérez, Mariana, Zagorac, Branislava, Francescutti, Dina M., Shaffer, Zachary D., Theis, Kevin R., Kuhn, Donald M.

“…Cocaine is a highly addictive psychostimulant drug of abuse that constitutes an ongoing public health threat. Emerging research is revealing that numerous…”
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Potential mechanisms underlying anxiety and depression in Parkinson's disease: Consequences of l-DOPA treatment by Eskow Jaunarajs, Karen L., Angoa-Perez, Mariana, Kuhn, Donald M., Bishop, Christopher

“…▶ Parkinson's disease patients have high incidences of affective disorders. ▶l-DOPA treatment does not reliably improve affective symptoms. ▶l-DOPA is taken up…”
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Effects of a high fat diet on gut microbiome dysbiosis in a mouse model of Gulf War Illness by Angoa-Pérez, Mariana, Zagorac, Branislava, Francescutti, Dina M., Winters, Andrew D., Greenberg, Jonathan M., Ahmad, Madison M., Manning, Shannon D., Gulbransen, Brian D., Theis, Kevin R., Kuhn, Donald M.

“…Gulf War Illness (GWI) is a chronic health condition that appeared in Veterans after returning home from the Gulf War. The primary symptoms linked to…”
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Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity by Angoa-Pérez, Mariana, Kane, Michael J., Briggs, Denise I., Sykes, Catherine E., Shah, Mrudang M., Francescutti, Dina M., Rosenberg, David R., Thomas, David M., Kuhn, Donald M.

“…J. Neurochem. (2012) 121, 974–984. Neuropsychiatric disorders characterized by behavioral disinhibition, including disorders of compulsivity (e.g…”
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Animal models of sports‐related head injury: bridging the gap between pre‐clinical research and clinical reality by Angoa‐Pérez, Mariana, Kane, Michael J., Briggs, Denise I., Herrera‐Mundo, Nieves, Viano, David C., Kuhn, Donald M.

“…Sports‐related head impact and injury has become a very highly contentious public health and medico‐legal issue. Near‐daily news accounts describe the travails…”
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Long access heroin self-administration significantly alters gut microbiome composition and structure by Greenberg, Jonathan M, Winters, Andrew D, Zagorac, Branislava, Kracht, David J, Francescutti, Dina M, Cannella, Nazzareno, Ciccocioppo, Roberto, Woods, Leah C Solberg, Mackle, James, Hardiman, Gary T, Kuhn, Brittany N, Kalivas, Peter W, Kuhn, Donald M, Angoa-Perez, Mariana

“…It is well known that chronic opioid use disorder is associated with alterations in gastrointestinal (GI) function that include constipation, reduced motility,…”
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Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation by Thomas, David M, Walker, Paul D, Benjamins, Joyce A, Geddes, Timothy J, Kuhn, Donald M

“…Methamphetamine intoxication causes long-lasting damage to dopamine nerve endings in the striatum. The mechanisms underlying this neurotoxicity are not known…”
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MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity by Thomas, David M., Kuhn, Donald M.

“…Methamphetamine causes long-term toxicity to dopamine nerve endings of the striatum. Evidence is emerging that microglia can contribute to the neuronal damage…”
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Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility by Jiménez-Trejo, Francisco, Tapia-Rodríguez, Miguel, Cerbón, Marco, Kuhn, Donald M, Manjarrez-Gutiérrez, Gabriel, Mendoza-Rodríguez, C Adriana, Picazo, Ofir

“…Serotonin (5-hydroxytryptamine; C10H12N2O (5-HT)) is produced in the CNS and in some cells of peripheral tissues. In the mammalian male reproductive system,…”
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role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum by Thomas, David M, Pérez, Mariana Angoa, Francescutti-Verbeem, Dina M, Shah, Mrudang M, Kuhn, Donald M

“…J. Neurochem. (2010) 115, 595-605. Methamphetamine (METH) is a neurotoxic drug of abuse that damages the dopamine (DA) neuronal system in a highly delimited…”
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Brain serotonin signaling does not determine sexual preference in male mice by Angoa-Pérez, Mariana, Herrera-Mundo, Nieves, Kane, Michael J, Sykes, Catherine E, Anneken, John H, Francescutti, Dina M, Kuhn, Donald M

“…It was reported recently that male mice lacking brain serotonin (5-HT) lose their preference for females (Liu et al., 2011, Nature, 472, 95-100), suggesting a…”
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The effect of brain serotonin deficiency on breathing is magnified by age by Pho, Huy, Amorim, Mateus R., Qiu, Qingchao, Shin, Mi‐Kyung, Kim, Lenise J., Anokye‐Danso, Frederick, Jun, Jonathan J., Ahima, Rexford S., Branco, Luiz G. S., Kuhn, Donald M., Mateika, Jason H., Polotsky, Vsevolod Y.

“…Serotonin is an important mediator modulating behavior, metabolism, sleep, control of breathing, and upper airway function, but the role of aging in…”
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Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines by Thomas, David M., Dowgiert, Jennifer, Geddes, Timothy J., Francescutti-Verbeem, Dina, Liu, Xiuli, Kuhn, Donald M.

“…Neurotoxic amphetamines cause damage to monoamine nerve terminals of the striatum by unknown mechanisms. Microglial activation contributes to the neuronal…”
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Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine by Thomas, David M., Kuhn, Donald M.

“…Methamphetamine causes persistent damage to dopamine nerve endings of the striatum. Repeated, intermittent treatment of mice with low doses of methamphetamine…”
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Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight by Angoa-Pérez, Mariana, Kuhn, Donald M

“…The gut microbiome modulates neurochemical function and behavior and has been implicated in numerous central nervous system (CNS) diseases, including…”
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The pharmacology and neurotoxicology of synthetic cathinones by Angoa-Perez, Mariana, Kuhn, Donald M

“…The synthetic cathinones are man-made compounds derived from the naturally occurring drug cathinone, which is found in the khat plant. The drugs in this…”
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Dopamine Disposition in the Presynaptic Process Regulates the Severity of Methamphetamine-Induced Neurotoxicity by Kuhn, Donald M., Francescutti-Verbeem, Dina M., Thomas, David M.

“…Methamphetamine (METH) is well known for its ability to cause damage to dopamine (DA) nerve endings of the striatum. The mechanisms by which METH causes…”
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