Search Results - "Kuhn, Norine"

12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response by Cole, Banumathi K, Kuhn, Norine S, Green-Mitchell, Shamina M, Leone, Kendall A, Raab, Rebekah M, Nadler, Jerry L, Chakrabarti, Swarup K

“…Central obesity is associated with chronic inflammation, insulin resistance, β-cell dysfunction, and endoplasmic reticulum (ER) stress. The 12/15-lipoxygenase…”
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Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development by Green-Mitchell, Shamina M, Tersey, Sarah A, Cole, Banumathi K, Ma, Kaiwen, Kuhn, Norine S, Cunningham, Tina Duong, Maybee, Nelly A, Chakrabarti, Swarup K, McDuffie, Marcia, Taylor-Fishwick, David A, Mirmira, Raghavendra G, Nadler, Jerry L, Morris, Margaret A

“…Type 1 diabetes (T1D) is characterized by autoimmune depletion of insulin-producing pancreatic beta cells. We showed previously that deletion of the…”
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Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects by Dobrian, Anca D., Lieb, David C., Ma, Qian, Lindsay, John W., Cole, Banumathi K., Ma, Kaiwen, Chakrabarti, Swarup K., Kuhn, Norine S., Wohlgemuth, Stephen D., Fontana, Mark, Nadler, Jerry L.

“…► ALOX15A is selectively expressed only in the omental adipose tissue in obese humans. ► Expression of all 12/15 ALOX isoforms is increased in omental vs…”
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Bariatric Surgery Decreases Monocyte-Platelet Aggregates in Blood: a Pilot Study by Periasamy, Monica, Lieb, David C., Butcher, Matthew J., Kuhn, Norine, Galkina, Elena, Fontana, Mark, Wohlgemuth, Stephen, Nadler, Jerry L., Dobrydneva, Yuliya

“…Morbid obesity is accompanied by platelet hyperactivity, leading to thrombotic events including myocardial infarction and stroke. Bariatric surgery is an…”
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Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development by Green-Mitchell, Shamina M., Tersey, Sarah A., Cole, Banumathi K., Ma, Kaiwen, Kuhn, Norine S., Cunningham, Tina Duong, Maybee, Nelly A., Chakrabarti, Swarup K., McDuffie, Marcia, Taylor-Fishwick, David A., Mirmira, Raghavendra G., Nadler, Jerry L., Morris, Margaret A.

“…Aims Type 1 diabetes (T1D) is characterized by autoimmune depletion of insulin-producing pancreatic beta cells. We showed previously that deletion of the…”
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Synthesis and Structure–Activity Relationship Studies of 4‑((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase by Luci, Diane K., Jameson, J. Brian, Yasgar, Adam, Diaz, Giovanni, Joshi, Netra, Kantz, Auric, Markham, Kate, Perry, Steve, Kuhn, Norine, Yeung, Jennifer, Kerns, Edward H., Schultz, Lena, Holinstat, Michael, Nadler, Jerry L., Taylor-Fishwick, David A., Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R., Maloney, David J.

“…Human lipoxygenases (LOXs) are a family of iron-containing enzymes which catalyze the oxidation of polyunsaturated fatty acids to provide the corresponding…”
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Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction by Taylor-Fishwick, David A., Weaver, Jessica, Glenn, Lindsey, Kuhn, Norine, Rai, Ganesha, Jadhav, Ajit, Simeonov, Anton, Dudda, Angela, Schmoll, Dieter, Holman, Theodore R., Maloney, David J., Nadler, Jerry L.

“…Aims/hypothesis Islet inflammation leads to loss of functional pancreatic beta cell mass. Increasing evidence suggests that activation of 12-lipoxygenase leads…”
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Weight‐loss surgery rapidly alleviates platelet hyperactivity in morbid obesity by Dobrydneva, Yuliya, Periasamy, Monica, Butcher, Matthew, Galkina, Elena, Kuhn, Norine, Lieb, David, Fontana, Mark, Wohlgemuth, Steven, Nadler, Jerry

“…Abstract only Morbid obesity is accompanied by platelet hyperactivity, leading to thrombotic events such as myocardial infarction and stroke. Platelets are…”
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Weight loss surgery decreases platelet activation in morbidly obese patients by Dobrydneva, Yuliya, Periasamy, Monica, Galkina, Elena, Kuhn, Norine, Lieb, David, Fontana, Mark, Wohlgemuth, Stephen, Nadler, Jerry

“…Abstract only Bariatric surgery is the most effective treatment to alleviate morbid obesity and its comorbidities, such as type 2 diabetes. Platelets are…”
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Bariatric surgery decreases level of platelet‐monocyte aggregates in morbidly obese patients by Dobrydneva, Yuliya, Taylor, Ashley, Galkina, Elena, Kuhn, Norine, Lieb, David, Fontana, Mark, Wohlgemuth, Stephen, Nadler, Jerry

“…Bariatric surgery is the most effective treatment for morbid obesity and the resulting type 2 diabetes. Platelets are crucial for the development of thrombosis…”
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Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15.sup.null Mice, Leading to Protection against Type 1 Diabetes Development by Green-Mitchell, Shamina M, Tersey, Sarah A, Cole, Banumathi K, Ma, Kaiwen, Kuhn, Norine S, Cunningham, Tina Duong, Maybee, Nelly A, Chakrabarti, Swarup K, McDuffie, Marcia, Taylor-Fishwick, David A, Mirmira, Raghavendra G, Nadler, Jerry L, Morris, Margaret A

“…Aims Type 1 diabetes (T1D) is characterized by autoimmune depletion of insulin-producing pancreatic beta cells. We showed previously that deletion of the…”
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