Search Results - "Kuhn, Chantal"

Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside by Kuhn, Chantal, Weiner, Howard L

“…The induction of tolerance is a major goal of immunotherapy. Investigations over the last 20 years have shown that anti-CD3 monoclonal antibodies (mAbs)…”
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MicroRNA-146a limits tumorigenic inflammation in colorectal cancer by Garo, Lucien P., Ajay, Amrendra K., Fujiwara, Mai, Gabriely, Galina, Raheja, Radhika, Kuhn, Chantal, Kenyon, Brendan, Skillin, Nathaniel, Kadowaki-Saga, Ryoko, Saxena, Shrishti, Murugaiyan, Gopal

“…Chronic inflammation can drive tumor development. Here, we have identified microRNA-146a (miR-146a) as a major negative regulator of colonic inflammation and…”
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Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity by Garo, Lucien P., Ajay, Amrendra K., Fujiwara, Mai, Beynon, Vanessa, Kuhn, Chantal, Gabriely, Galina, Sadhukan, Supriya, Raheja, Radhika, Rubino, Stephen, Weiner, Howard L., Murugaiyan, Gopal

“…Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis and treatment of inflammatory bowel diseases (IBDs), including Crohn's…”
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γδ T cells control humoral immune response by inducing T follicular helper cell differentiation by Rezende, Rafael M., Lanser, Amanda J., Rubino, Stephen, Kuhn, Chantal, Skillin, Nathaniel, Moreira, Thais G., Liu, Shirong, Gabriely, Galina, David, Bruna A., Menezes, Gustavo B., Weiner, Howard L.

“…γδ T cells have many known functions, including the regulation of antibody responses. However, how γδ T cells control humoral immunity remains elusive. Here we…”
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Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance by Rezende, Rafael M, Cox, Laura M, Moreira, Thais G, Liu, Shirong, Boulenouar, Selma, Dhang, Fyonn, LeServe, Danielle S, Nakagaki, Brenda N, Lopes, Juliana R, Tatematsu, Bruna K, Lemos, Luisa, Mayrink, Julia, Lobo, Eduardo L C, Guo, Lydia, Oliveira, Marilia G, Kuhn, Chantal, Weiner, Howard L

“…Gamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota composition. Little is…”
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Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes by You, Sylvaine, Piali, Luca, Kuhn, Chantal, Steiner, Beat, Sauvaget, Virginia, Valette, Fabrice, Clozel, Martine, Bach, Jean-François, Chatenoud, Lucienne

“…In the present study, we investigated the therapeutic potential of a selective S1P1 receptor modulator, ponesimod, to protect and reverse autoimmune diabetes…”
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Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance by Kuhn, Chantal, You, Sylvaine, Valette, Fabrice, Hale, Geoff, van Endert, Peter, Bach, Jean-François, Waldmann, Herman, Chatenoud, Lucienne

“…Monoclonal antibodies have proven to be potent agents to promote immunological tolerance in animal models of autoimmune disease and transplantation. However,…”
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Immune response to human embryonic stem cell‐derived cardiac progenitors and adipose‐derived stromal cells by Calderon, Damelys, Planat‐Benard, Valérie, Bellamy, Valérie, Vanneaux, Valérie, Kuhn, Chantal, Peyrard, Severine, Larghero, Jéröome, Desnos, Michel, Casteilla, Louis, Pucéat, Michel, Menasché, Philippe, Chatenoud, Lucienne

“…Transplantation of allogeneic human embryonic stem cell‐derived cardiac progenitors triggers an immune response. We assessed whether this response could be…”
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Boosting the career development of postdocs with a peer-to-peer mentor circles program: mentor circles combine the advantages of both mentoring networks and peer-to-peer mentoring by Kuhn, Chantal, Castano, Zafira

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Boosting the career development of postdocs with a peer-to-peer mentor circles program by Kuhn, Chantal, Castaño, Zafira

“…Mentor circles combine the advantages of both mentoring networks and peer-to-peer mentoring…”
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IL-6R signaling inhibits generation of Th3 cells and is a promising therapeutic target for enhancing oral tolerance induction by Kuhn, Chantal, Rezende, Rafael, Weiner, Howard L

“…Abstract Oral antigen administration results in systemic hyporesponsiveness to a subsequent challenge with the fed antigen (oral tolerance) and has been shown…”
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Immunology. How does the immune system tolerate food? by Kuhn, Chantal, Weiner, Howard L

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How does the immune system tolerate food? by Kuhn, Chantal, Weiner, Howard L.

“…Intestinal T cells balance the immune response to microbes and food [Also see Report by Kim et al. ] The gastrointestinal immune system (gut-associated…”
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IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance by Kuhn, Chantal, Rezende, Rafael Machado, M'Hamdi, Hanane, da Cunha, Andre Pires, Weiner, Howard L

“…Oral administration of Ag induces regulatory T cells that express latent membrane-bound TGF-β (latency-associated peptide [LAP]) and have been shown to play an…”
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γδ T Cell-Secreted XCL1 Mediates Anti-CD3-Induced Oral Tolerance by Rezende, Rafael M, Nakagaki, Brenda N, Moreira, Thais G, Lopes, Juliana R, Kuhn, Chantal, Tatematsu, Bruna K, Boulenouar, Selma, Maghzi, Amir-Hadi, Rubino, Stephen, Menezes, Gustavo B, Chitnis, Tanuja, Weiner, Howard L

“…Oral tolerance is defined as the specific suppression of cellular and/or humoral immune responses to an Ag by prior administration of the Ag through the oral…”
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Regulatory mechanisms of immune tolerance in type 1 diabetes and their failures by Kuhn, Chantal, Besançon, Alix, Lemoine, Sébastien, You, Sylvaine, Marquet, Cindy, Candon, Sophie, Chatenoud, Lucienne

“…Abstract In this brief review we propose to discuss salient data showing the importance of immune regulatory mechanisms, and in particular of Treg, for the…”
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Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice by Ogura, Mineko, Deng, Songyan, Preston-Hurlburt, Paula, Ogura, Hideki, Shailubhai, Kunwar, Kuhn, Chantal, Weiner, Howard L., Herold, Kevan C.

“…Oral administration of biologics may be a feasible approach for immune therapy that improves drug safety and potentiates mechanisms of tolerance at mucosal…”
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Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain by Kuhn, Chantal, Rezende, Rafael M, da Cunha, Andre Pires, Valette, Fabrice, Quintana, Francisco J, Chatenoud, Lucienne, Weiner, Howard L

“…Abstract CD3-specific monoclonal antibody (mAb) treats autoimmune disease in animal models and has shown promise in clinical trials of type 1 diabetes. Whereas…”
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Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet allograft acceptance by Baas, Marije C, Kuhn, Chantal, Valette, Fabrice, Mangez, Claire, Duarte, Mercedes Segovia, Hill, Marcelo, Besançon, Alix, Chatenoud, Lucienne, Cuturi, Maria-Cristina, You, Sylvaine

“…Cell therapy and the use of mAbs that interfere with T cell effector functions constitute promising approaches for the control of allograft rejection. In the…”
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Time to evolve: predicting engineered T cell-associated toxicity with next-generation models by Donnadieu, Emmanuel, Luu, Maik, Alb, Miriam, Anliker, Brigitte, Arcangeli, Silvia, Bonini, Chiara, De Angelis, Biagio, Choudhary, Rashmi, Espie, David, Galy, Anne, Holland, Cam, Ivics, Zoltán, Kantari-Mimoun, Chahrazade, Kersten, Marie Jose, Köhl, Ulrike, Kuhn, Chantal, Laugel, Bruno, Locatelli, Franco, Marchiq, Ibtissam, Markman, Janet, Moresco, Marta Angiola, Morris, Emma, Negre, Helene, Quintarelli, Concetta, Rade, Michael, Reiche, Kristin, Renner, Matthias, Ruggiero, Eliana, Sanges, Carmen, Stauss, Hans, Themeli, Maria, Van den Brulle, Jan, Hudecek, Michael, Casucci, Monica

“…Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are…”
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