Search Results - "Kuhlmann, Jan Dominik"

Targeting Cancer Stem Cells: Promises and Challenges by Kuhlmann, Jan Dominik, Hein, Linda, Kurth, Ina, Wimberger, Pauline, Dubrovska, Anna

“…Recent discoveries have provided the compelling evidence that stem cell populations within each individual tumor are key contributors of therapy failure…”
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Mesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin by Deniz, Ilker A, Karbanová, Jana, Wobus, Manja, Bornhäuser, Martin, Wimberger, Pauline, Kuhlmann, Jan Dominik, Corbeil, Denis

“…Multipotent mesenchymal stromal cells (MSCs) are precursors of various cell types. Through soluble factors, direct cell-cell interactions and other…”
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Gene expression profiling of single circulating tumor cells in ovarian cancer – Establishment of a multi-marker gene panel by Blassl, Christina, Kuhlmann, Jan Dominik, Webers, Alessandra, Wimberger, Pauline, Fehm, Tanja, Neubauer, Hans

“…The presence of circulating tumor cells (CTCs) in the blood of ovarian cancer patients was shown to correlate with decreased overall survival, whereby CTCs…”
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EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy by Chebouti, Issam, Kasimir-Bauer, Sabine, Buderath, Paul, Wimberger, Pauline, Hauch, Siegfried, Kimmig, Rainer, Kuhlmann, Jan Dominik

“…Assuming that tumor cell dissemination requires a shift to a mesenchymal phenotype, we analyzed the incidence of epithelial-to-mesenchymal-transition…”
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ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance by Kuhlmann, Jan Dominik, Wimberger, Pauline, Bankfalvi, Agnes, Keller, Thomas, Schöler, Sarah, Aktas, Bahriye, Buderath, Paul, Hauch, Siegfried, Otterbach, Friedrich, Kimmig, Rainer, Kasimir-Bauer, Sabine

“…Platinum resistance constitutes one of the most recognized clinical challenges for ovarian cancer. Notably, the detection of the primary tumor-based excision…”
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Urinary-based detection of MSL, HE4 and CA125 as an additional dimension for predictive and prognostic modelling in ovarian cancer by Schwarz, Franziska Maria, Klotz, Daniel Martin, Wimberger, Pauline, Kuhlmann, Jan Dominik

“…We have recently described a predictive/prognostic model for ovarian cancer, exploiting commonly available clinico-pathological parameters and the ovarian…”
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Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer by Göbel, Andy, Zinna, Valentina M, Dell'Endice, Stefania, Jaschke, Nikolai, Kuhlmann, Jan Dominik, Wimberger, Pauline, Rachner, Tilman D

“…Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases,…”
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Prognostic relevance of longitudinal HGF levels in serum of patients with ovarian cancer by Klotz, Daniel Martin, Link, Theresa, Wimberger, Pauline, Kuhlmann, Jan Dominik

“…The pleiotropic protein hepatocyte growth factor (HGF) is the only known ligand of the tyrosine kinase mesenchymal–epithelial transition (cMET) receptor. The…”
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Induction of circulating ABCB1 transcripts under platinum-based chemotherapy indicates poor prognosis and a bone micrometastatic phenotype in ovarian cancer patients by Schwarz, Franziska Maria, Kuhlmann, Jan Dominik, Kämpfer, Jorrin, Klimova, Anna, Klotz, Daniel Martin, Freitag, Lisa, Herrmann, Pia, Zinnow, Viktoria, Smith, Janice, Scheller, Theresia, Walther, Wolfgang, Wimberger, Pauline, Stein, Ulrike

“…The drug efflux transporter P-glycoprotein, encoded by the ABCB1 gene, promotes acquired chemoresistance. We explored the presence and clinical relevance of…”
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Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales by Ludwig, Anna-Kristin, De Miroschedji, Kyra, Doeppner, Thorsten R., Börger, Verena, Ruesing, Johannes, Rebmann, Vera, Durst, Stephan, Jansen, Sören, Bremer, Michel, Behrmann, Elmar, Singer, Bernhard B., Jastrow, Holger, Kuhlmann, Jan Dominik, El Magraoui, Fouzi, Meyer, Helmut E., Hermann, Dirk M., Opalka, Bertram, Raunser, Stefan, Epple, Matthias, Horn, Peter A., Giebel, Bernd

“…Extracellular vesicles (EVs) provide a complex means of intercellular signalling between cells at local and distant sites, both within and between different…”
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The levels of soluble cMET ectodomain in the blood of patients with ovarian cancer are an independent prognostic biomarker by Klotz, Daniel Martin, Link, Theresa, Goeckenjan, Maren, Wimberger, Pauline, Kuhlmann, Jan Dominik

“…The tyrosine kinase mesenchymal–epithelial transition (cMET) is typically overexpressed in up to 75% of patients with ovarian cancer, and cMET overexpression…”
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Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer by Link, Theresa, Kuhlmann, Jan Dominik, Kobelt, Dennis, Herrmann, Pia, Vassileva, Yana D., Kramer, Michael, Frank, Kerstin, Göckenjan, Maren, Wimberger, Pauline, Stein, Ulrike

“…Metastasis‐associated in colon cancer 1 (MACC1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For…”
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ERCC1-expressing circulating tumor cells as a potential diagnostic tool for monitoring response to platinum-based chemotherapy and for predicting post-therapeutic outcome of ovarian cancer by Chebouti, Issam, Kuhlmann, Jan Dominik, Buderath, Paul, Weber, Stephan, Wimberger, Pauline, Bokeloh, Yvonne, Hauch, Siegfried, Kimmig, Rainer, Kasimir-Bauer, Sabine

“…We recently showed that the presence of ERCC1+CTCs is an independent predictive biomarker for platinum-resistance and poor prognosis of ovarian cancer. The…”
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The effect of denosumab on disseminated tumor cells (DTCs) of breast cancer patients with neoadjuvant treatment: a GeparX translational substudy by Wimberger, Pauline, Blohmer, Jens-Uwe, Krabisch, Petra, Link, Theresa, Just, Marianne, Sinn, Bruno Valentin, Simon, Eike, Solbach, Christine, Fehm, Tanja, Denkert, Carsten, Kühn, Cristin, Rhiem, Kerstin, Tesch, Hans, Kümmel, Sherko, Petzold, Andrea, Stötzer, Oliver, Meisel, Cornelia, Kuhlmann, Jan Dominik, Nekljudova, Valentina, Loibl, Sibylle

“…Disseminated tumor cells (DTCs) in the bone marrow are observed in about 40% at primary diagnosis of breast cancer and predict poor survival. While…”
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A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow by Rossnagl, Stephanie, Ghura, Hiba, Groth, Christopher, Altrock, Eva, Jakob, Franz, Schott, Sarah, Wimberger, Pauline, Link, Theresa, Kuhlmann, Jan Dominik, Stenzl, Arnulf, Hennenlotter, Jörg, Todenhöfer, Tilmann, Rojewski, Markus, Bieback, Karen, Nakchbandi, Inaam A

“…Breast and prostate cancer cells home to the bone marrow, where they presumably hijack the hematopoietic stem cell niche. We characterize here the elusive…”
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microRNA and the pathogenesis of ovarian cancer--a new horizon for molecular diagnostics and treatment? by Kuhlmann, Jan Dominik, Rasch, Jens, Wimberger, Pauline, Kasimir-Bauer, Sabine

“…Ovarian cancer is the leading cause of death among gynecologic malignancies and despite advances in treatment, more than 50% of all patients will experience…”
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Clinical impact of soluble Neuropilin-1 in ovarian cancer patients and its association with its circulating ligands of the HGF/c-MET axis by Klotz, Daniel Martin, Kuhlmann, Jan Dominik, Link, Theresa, Goeckenjan, Maren, Hofbauer, Lorenz C., Göbel, Andy, Rachner, Tilman D., Wimberger, Pauline

“…Background Neuropilin (NRP) is a transmembrane protein, which has been shown to be a pro-angiogenic mediator and implicated as a potential driver of cancer…”
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Palbociclib impairs the proliferative capacity of activated T cells while retaining their cytotoxic efficacy by Arndt, Claudia, Tunger, Antje, Wehner, Rebekka, Rothe, Rebecca, Kourtellari, Eleni, Luttosch, Stephanie, Hannemann, Katharina, Koristka, Stefanie, Loureiro, Liliana R, Feldmann, Anja, Tonn, Torsten, Link, Theresa, Kuhlmann, Jan Dominik, Wimberger, Pauline, Bachmann, Michael Philipp, Schmitz, Marc

“…The cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor palbociclib is an emerging cancer therapeutic that just recently gained Food and Drug Administration…”
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Increased level of circulating U2 small nuclear RNA fragments indicates metastasis in melanoma patients by Kuhlmann, Jan Dominik, Wimberger, Pauline, Wilsch, Katja, Fluck, Michael, Suter, Ludwig, Brunner, Georg

“…Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse…”
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Identification and Functional Testing of ERCC2 Mutations in a Multi-national Cohort of Patients with Familial Breast- and Ovarian Cancer by Rump, Andreas, Benet-Pages, Anna, Schubert, Steffen, Kuhlmann, Jan Dominik, Janavičius, Ramūnas, Macháčková, Eva, Foretová, Lenka, Kleibl, Zdenek, Lhota, Filip, Zemankova, Petra, Betcheva-Krajcir, Elitza, Mackenroth, Luisa, Hackmann, Karl, Lehmann, Janin, Nissen, Anke, DiDonato, Nataliya, Opitz, Romy, Thiele, Holger, Kast, Karin, Wimberger, Pauline, Holinski-Feder, Elke, Emmert, Steffen, Schröck, Evelin, Klink, Barbara

“…The increasing application of gene panels for familial cancer susceptibility disorders will probably lead to an increased proposal of susceptibility gene…”
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