Search Results - "Kuhlman, P A"

Human Fascia Dentata Anatomy and Hippocampal Neuron Densities Differ Depending on the Epileptic Syndrome and Age at First Seizure by MATHERN, GARY W, KUHLMAN, PAULA A, MENDOZA, DELIA, PRETORIUS, JAMES K

“…This study determined fascia dentata anatomy and hippocampal neuron densities in patients with different epileptic syndromes. Based on presurgical data,…”
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CIS Display: In vitro Selection of Peptides from Libraries of Protein-DNA Complexes by Odegrip, Richard, Coomber, David, Eldridge, Bill, Hederer, Rosemarie, Kuhlman, Philip A., Ullman, Christopher, FitzGerald, Kevin, McGregor, Duncan, Klug, Aaron

“…We describe the development of an in vitro library selection system (CIS display) that exploits the ability of a DNA replication initiator protein (RepA) to…”
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The identification and characterisation of an actin-binding site in α-actinin by mutagenesis by Kuhlman, Philip A., Hemmings, Lance, Critchley, David R.

“…We have shown previously that the N-terminal actin-binding domain of α-actinin retains activity when expressed in E. coli as a fusion protein with glutathione-…”
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Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining by Mathern, G W, Leite, J P, Babb, T L, Pretorius, J K, Kuhlman, P A, Mendoza, D, Fried, I, Sakamoto, A C, Assirati, J A, Adelson, P D, Peacock, W J

“…This study determined in temporal lobe epilepsy patients and rats injected with intrahippocampal kainate (KA) whether fascia dentata molecular layer mossy…”
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In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl-D-aspartate, AMPA and GABAA receptors by MATHERN, G. W, BERTRAM, E. H, BABB, T. L, PRETORIUS, J. K, KUHLMAN, P. A, SPRADLIN, S, MENDOZA, D

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The kinetics of the interaction between the actin-binding domain of α-actinin and F-actin by Kuhlman, Philip A., Ellis, Jacqueline, Critchley, David R., Bagshaw, Clive R.

“…Measurement of the binding equilibrium for the interaction of α-actinin with F-actin is complicated by secondary reactions involving cross-linking and/or…”
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The pathogenic and progressive features of chronic human hippocampal epilepsy by Mathern, Gary W., Babb, Thomas L., Leite, Joao P., Pretorius, James K., Yeoman, Kristin M., Kuhlman, Paula A.

“…To design useful experimental models of epilepsy, it is necessary to clearly understand the known clinical-pathologic features of the disease process. Studies…”
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In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl- d-aspartate, AMPA and GABA A receptors by Mathern, G.W, Bertram, E.H, Babb, T.L, Pretorius, J.K, Kuhlman, P.A, Spradlin, S, D. Mendoza

“…This study determined whether there were differences in hippocampal neuron loss and synaptic plasticity by comparing rats with spontaneous epilepsy after…”
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Characterization of the actin filament capping state in human erythrocyte ghost and cytoskeletal preparations by Kuhlman, P A

“…The narrow Gaussian-length-distribution of actin filaments forming the cytoskeleton of the human erythrocyte indicates the existence of strict mechanisms for…”
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Analysis of the Actin-Binding Domain of α-Actinin by Mutagenesis and Demonstration That Dystrophin Contains a Functionally Homologous Domain by Hemmings, Lance, Kuhlman, Philip A., Critchley, David R.

“…To define the actin-binding site within the NH2-terminal domain (residues 1-245) of chick smooth muscle α-actinin, we expressed a series of α-actinin deletion…”
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Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats by Leite, João P., Babb, Thomas L., Pretorius, James K., Kuhlman, Paula A., Yeoman, Kristin M., Mathern, Gary W.

“…This study determined neuron losses, mossy fiber sprouting, and interictal spike frequencies in adult rats following intrahippocampal kainic acid (KA)…”
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Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy by Babb, Thomas L., Mathern, Gary W., Leite, Joao P., Pretorius, James K., Yeoman, Kristin M., Kuhlman, Paula A.

“…The present study examined the relationship between the patterns and densities of glutamate AMPA receptor sub-units GluR1 and GluR2/3 in the molecular layer of…”
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ATPase kinetics of the Dictyostelium discoideum myosin II motor domain by Kuhlman, P A, Bagshaw, C R

“…Structural characterization of the mode of interaction of nucleotides bound to myosin has relied upon the crystal structure of the Dictyostelium discoideum…”
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Measurement of ATPase activities of myosin at the level of tracks and single molecules by Conibear, P B, Kuhlman, P A, Bagshaw, C R

“…In order to determine the degree of mechanochemical coupling in actomyosin in vitro motility assays, it is desirable to measure the sliding velocity and the…”
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A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments by Kuhlman, P A, Hughes, C A, Bennett, V, Fowler, V M

“…Adducin is a membrane skeleton protein originally described in human erythrocytes that promotes the binding of spectrin to actin and also binds directly to…”
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Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin by Kuhlman, P A, Fowler, V M

“…CapZ ("capping protein") is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament…”
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X-ray crystal structure and solution fluorescence characterization of Mg.2'(3')-O-(N-methylanthraniloyl) nucleotides bound to the Dictyostelium discoideum myosin motor domain by Bauer, C B, Kuhlman, P A, Bagshaw, C R, Rayment, I

“…Mant (2'(3')-O-(N-methylanthraniloyl)) labeled nucleotides have proven to be useful tools in the study of the kinetic mechanism of the myosin ATPase by…”
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Analysis of the actin-binding domain of α-actinin by mutagenesis and demonstration that dystrophin constains a functionally homologous domain by HEMMINGS, L, KUHLMAN, P. A, CRITCHLEY, D. R

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X-ray crystal structure and solution fluorescence characterization of Mg·2′(3′)- O-( N-methylanthraniloyl) nucleotides bound to the Dictyostelium discoideum myosin motor domain by Bauer, Cary B, Kuhlman, Philip A, Bagshaw, Clive R, Rayment, Ivan

“…Mant (2′(3′)- O-( N-methylanthraniloyl)) labeled nucleotides have proven to be useful tools in the study of the kinetic mechanism of the myosin ATPase by…”
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Dynamic changes in the length distribution of actin filaments during polymerization can be modulated by barbed end capping proteins by Kuhlman, Philip A.

“…During actin polymerization, it has been theorized that the actin filament length distribution initially grows in the form of a Gaussian before converting to…”
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