Search Results - "Kuhle, Jens"

Serum neurofilament light levels in normal aging and their association with morphologic brain changes by Khalil, Michael, Pirpamer, Lukas, Hofer, Edith, Voortman, Margarete M., Barro, Christian, Leppert, David, Benkert, Pascal, Ropele, Stefan, Enzinger, Christian, Fazekas, Franz, Schmidt, Reinhold, Kuhle, Jens

“…Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also in serum, which allows for…”
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Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis by Siller, Nelly, Kuhle, Jens, Muthuraman, Muthuraman, Barro, Christian, Uphaus, Timo, Groppa, Sergiu, Kappos, Ludwig, Zipp, Frauke, Bittner, Stefan

“…Background: Monitoring neuronal injury remains one key challenge in early relapsing-remitting multiple sclerosis (RRMS) patients. Upon axonal damage,…”
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Serum NfL levels should be used to monitor multiple sclerosis evolution – Yes by Leppert, David, Kuhle, Jens

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Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity by Högel, Heidi, Rissanen, Eero, Barro, Christian, Matilainen, Markus, Nylund, Marjo, Kuhle, Jens, Airas, Laura

“…Background: Cerebrospinal fluid (CSF) levels of two soluble biomarkers, glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), have been…”
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Blood neurofilament light chain as a biomarker of MS disease activity and treatment response by Kuhle, Jens, Kropshofer, Harald, Haering, Dieter A, Kundu, Uma, Meinert, Rolf, Barro, Christian, Dahlke, Frank, Tomic, Davorka, Leppert, David, Kappos, Ludwig

“…OBJECTIVETo assess the value of blood neurofilament light chain (NfL) as a biomarker of recent, ongoing, and future disease activity and tissue damage and its…”
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Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis by Barro, Christian, Benkert, Pascal, Disanto, Giulio, Tsagkas, Charidimos, Amann, Michael, Naegelin, Yvonne, Leppert, David, Gobbi, Claudio, Granziera, Cristina, Yaldizli, Özgür, Michalak, Zuzanna, Wuerfel, Jens, Kappos, Ludwig, Parmar, Katrin, Kuhle, Jens

“…See Giovannoni (doi:10.1093/brain/awy200) for a scientific commentary on this article. Biomarkers of tissue damage in multiple sclerosis are urgently needed…”
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Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa by Kuhle, Jens, Barro, Christian, Andreasson, Ulf, Derfuss, Tobias, Lindberg, Raija, Sandelius, Åsa, Liman, Victor, Norgren, Niklas, Blennow, Kaj, Zetterberg, Henrik

“…Neuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are specific cytoskeletal proteins of neurons and…”
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Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis by Disanto, Giulio, Barro, Christian, Benkert, Pascal, Naegelin, Yvonne, Schädelin, Sabine, Giardiello, Antonella, Zecca, Chiara, Blennow, Kaj, Zetterberg, Henrik, Leppert, David, Kappos, Ludwig, Gobbi, Claudio, Kuhle, Jens, Kuhle, Jens, Lorscheider, Johannes, Yaldizli, Özgür, Derfuss, Tobias, Kappos, Ludwig, Disanto, Giulio, Zecca, Chiara, Gobbi, Claudio, Benkert, Pascal, Achtnichts, Lutz, Nedeltchev, Krassen, Kamm, Christian P, Salmen, Anke, Chan, Andrew, Lalive, Patrice H, Pot, Caroline, Schluep, Myriam, Granziera, Cristina, Du Pasquier, Renaud, Müller, Stefanie, Vehoff, Jochen

“…Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in…”
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Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD by Watanabe, Mitsuru, Nakamura, Yuri, Michalak, Zuzanna, Isobe, Noriko, Barro, Christian, Leppert, David, Matsushita, Takuya, Hayashi, Fumie, Yamasaki, Ryo, Kuhle, Jens, Kira, Jun-ichi

“…OBJECTIVETo test the hypothesis that serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), which are an intermediate…”
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Neurofilaments: neurobiological foundations for biomarker applications by Gafson, Arie R, Barthélemy, Nicolas R, Bomont, Pascale, Carare, Roxana O, Durham, Heather D, Julien, Jean-Pierre, Kuhle, Jens, Leppert, David, Nixon, Ralph A, Weller, Roy O, Zetterberg, Henrik, Matthews, Paul M

“…Interest in neurofilaments has risen sharply in recent years with recognition of their potential as biomarkers of brain injury or neurodegeneration in CSF and…”
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Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases by Bacioglu, Mehtap, Maia, Luis F., Preische, Oliver, Schelle, Juliane, Apel, Anja, Kaeser, Stephan A., Schweighauser, Manuel, Eninger, Timo, Lambert, Marius, Pilotto, Andrea, Shimshek, Derya R., Neumann, Ulf, Kahle, Philipp J., Staufenbiel, Matthias, Neumann, Manuela, Maetzler, Walter, Kuhle, Jens, Jucker, Mathias

“…A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative diseases target their characteristic proteopathic lesions…”
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Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis by Weydt, Patrick, Oeckl, Patrick, Huss, André, Müller, Kathrin, Volk, Alexander E., Kuhle, Jens, Knehr, Antje, Andersen, Peter M., Prudlo, Johannes, Steinacker, Petra, Weishaupt, Jochen H., Ludolph, Albert C., Otto, Markus

“…Neurofilaments are elevated in the cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients. However, timing of this increase is…”
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Comparative analysis of natalizumab versus fingolimod as second-line treatment in relapsing–remitting multiple sclerosis by Lorscheider, Johannes, Benkert, Pascal, Lienert, Carmen, Hänni, Peter, Derfuss, Tobias, Kuhle, Jens, Kappos, Ludwig, Yaldizli, Özgür

“…Background: No randomized controlled trials have compared the efficacy of fingolimod or natalizumab as second-line treatment in patients with…”
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Serum neurofilament light chain level associations with clinical and cognitive performance in multiple sclerosis: A longitudinal retrospective 5-year study by Jakimovski, Dejan, Zivadinov, Robert, Ramanthan, Murali, Hagemeier, Jesper, Weinstock-Guttman, Bianca, Tomic, Davorka, Kropshofer, Harald, Fuchs, Tom A, Barro, Christian, Leppert, David, Yaldizli, Özgür, Kuhle, Jens, Benedict, Ralph HB

“…Background: A limited number of studies investigated associations between serum neurofilament light chain (sNfL) and cognition in persons with multiple…”
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Neurofilament light levels are associated with long-term outcomes in multiple sclerosis by Kuhle, Jens, Plavina, Tatiana, Barro, Christian, Disanto, Giulio, Sangurdekar, Dipen, Singh, Carol M, de Moor, Carl, Engle, Bob, Kieseier, Bernd C, Fisher, Elizabeth, Kappos, Ludwig, Rudick, Richard A, Goyal, Jaya

“…Background: Neurofilament light chain (NfL) is a promising marker of disease activity/treatment response in multiple sclerosis (MS), although its predictive…”
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Increased neurofilament light chain blood levels in neurodegenerative neurological diseases by Gaiottino, Johanna, Norgren, Niklas, Dobson, Ruth, Topping, Joanne, Nissim, Ahuva, Malaspina, Andrea, Bestwick, Jonathan P, Monsch, Andreas U, Regeniter, Axel, Lindberg, Raija L, Kappos, Ludwig, Leppert, David, Petzold, Axel, Giovannoni, Gavin, Kuhle, Jens

“…Neuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their…”
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Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis by Feneberg, Emily, Oeckl, Patrick, Steinacker, Petra, Verde, Federico, Barro, Christian, Van Damme, Philip, Gray, Elizabeth, Grosskreutz, Julian, Jardel, Claude, Kuhle, Jens, Koerner, Sonja, Lamari, Foudil, Amador, Maria del Mar, Mayer, Benjamin, Morelli, Claudia, Muckova, Petra, Petri, Susanne, Poesen, Koen, Raaphorst, Joost, Salachas, François, Silani, Vincenzo, Stubendorff, Beatrice, Turner, Martin R, Verbeek, Marcel M, Weishaupt, Jochen H, Weydt, Patrick, Ludolph, Albert C, Otto, Markus

“…OBJECTIVETo examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis…”
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Neurofilament levels are associated with blood–brain barrier integrity, lymphocyte extravasation, and risk factors following the first demyelinating event in multiple sclerosis by Uher, Tomas, McComb, Mason, Galkin, Shery, Srpova, Barbora, Oechtering, Johanna, Barro, Christian, Tyblova, Michaela, Bergsland, Niels, Krasensky, Jan, Dwyer, Michael, Havrdova, Eva Kubala, Posova, Helena, Vaneckova, Manuela, Zivadinov, Robert, Horakova, Dana, Kuhle, Jens, Ramanathan, Murali

“…Background: Increased blood brain barrier (BBB) permeability, CNS inflammation and neuroaxonal damage are pathological hallmarks in early multiple sclerosis…”
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Serum neurofilament light is increased in multiple system atrophy of cerebellar type and in repeat-expansion spinocerebellar ataxias: a pilot study by Wilke, Carlo, Bender, Friedemann, Hayer, Stefanie N., Brockmann, Kathrin, Schöls, Ludger, Kuhle, Jens, Synofzik, Matthis

“…Blood biomarkers in degenerative ataxias are still largely missing. Here, we aimed to provide piloting proof-of-concept that serum Neurofilament light (NfL)…”
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Confounding effect of blood volume and body mass index on blood neurofilament light chain levels by Manouchehrinia, Ali, Piehl, Fredrik, Hillert, Jan, Kuhle, Jens, Alfredsson, Lars, Olsson, Tomas, Kockum, Ingrid

“…Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of…”
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