Search Results - "Kugler, Matthias"

COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions by Brosnahan, Shari B., Jonkman, Annemijn H., Kugler, Matthias C., Munger, John S., Kaufman, David A.

“…The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19)…”
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Sonic hedgehog signaling in the lung. From development to disease by Kugler, Matthias C, Joyner, Alexandra L, Loomis, Cynthia A, Munger, John S

“…Over the past two decades, the secreted protein sonic hedgehog (SHH) has emerged as a critical morphogen during embryonic lung development, regulating the…”
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Alveolar Epithelial Cell Mesenchymal Transition Develops in vivo during Pulmonary Fibrosis and Is Regulated by the Extracellular Matrix by Kim, Kevin K., Kugler, Matthias C., Wolters, Paul J., Robillard, Liliane, Galvez, Michael G., Brumwell, Alexis N., Sheppard, Dean, Chapman, Harold A.

“…Mechanisms leading to fibroblast accumulation during pulmonary fibrogenesis remain unclear. Although there is in vitro evidence of lung alveolar…”
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Sonic Hedgehog Signaling Regulates Myofibroblast Function during Alveolar Septum Formation in Murine Postnatal Lung by Kugler, Matthias C, Loomis, Cynthia A, Zhao, Zhicheng, Cushman, Jennifer C, Liu, Li, Munger, John S

“…Sonic Hedgehog (Shh) signaling regulates mesenchymal proliferation and differentiation during embryonic lung development. In the adult lung, Shh signaling…”
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Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency by Spina, Elena, Simundza, Julia, Incassati, Angela, Chandramouli, Anupama, Kugler, Matthias C., Lin, Ziyan, Khodadadi-Jamayran, Alireza, Watson, Christine J., Cowin, Pamela

“…Gpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal guidance factors, that is implicated in planar polarity and control…”
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Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis by Kim, Kevin K, Wei, Ying, Szekeres, Charles, Kugler, Matthias C, Wolters, Paul J, Hill, Marla L, Frank, James A, Brumwell, Alexis N, Wheeler, Sarah E, Kreidberg, Jordan A, Chapman, Harold A

“…Pulmonary fibrosis, in particular idiopathic pulmonary fibrosis (IPF), results from aberrant wound healing and scarification. One population of fibroblasts…”
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Advances in Targeted Therapy for Progressive Fibrosing Interstitial Lung Disease by Gibson, Charlisa D., Kugler, Matthias C., Deshwal, Himanshu, Munger, John S., Condos, Rany

“…Progressive fibrosing interstitial lung disease (PF-ILD) has been redefined as a new clinical syndrome that shares similar genetics, pathophysiology, and…”
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Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages by Boytard, Ludovic, Hadi, Tarik, Silvestro, Michele, Qu, Hengdong, Kumpfbeck, Andrew, Sleiman, Rayan, Fils, Kissinger Hyppolite, Alebrahim, Dornazsadat, Boccalatte, Francesco, Kugler, Matthias, Corsica, Annanina, Gelb, Bruce E., Jacobowitz, Glenn, Miller, George, Bellini, Chiara, Oakes, Jessica, Silvestre, Jean-Sébastien, Zangi, Lior, Ramkhelawon, Bhama

“…Pulmonary disease increases the risk of developing abdominal aortic aneurysms (AAA). However, the mechanism underlying the pathological dialogue between the…”
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Hedgehog and Platelet-derived Growth Factor Signaling Intersect during Postnatal Lung Development by Yie, Ting-An, Loomis, Cynthia A, Nowatzky, Johannes, Khodadadi-Jamayran, Alireza, Lin, Ziyan, Cammer, Michael, Barnett, Clea, Mezzano, Valeria, Alu, Mark, Novick, Jackson A, Munger, John S, Kugler, Matthias C

“…Normal lung development critically depends on HH (Hedgehog) and PDGF (platelet-derived growth factor) signaling, which coordinate mesenchymal differentiation…”
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Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease by Sulaiman, Imran, Wu, Benjamin G, Chung, Matthew, Isaacs, Bradley, Tsay, Jun-Chieh J, Holub, Meredith, Barnett, Clea R, Kwok, Benjamin, Kugler, Matthias C, Natalini, Jake G, Singh, Shivani, Li, Yonghua, Schluger, Rosemary, Carpenito, Joseph, Collazo, Destiny, Perez, Luisanny, Kyeremateng, Yaa, Chang, Miao, Campbell, Christina D, Hansbro, Philip M, Oppenheimer, Beno W, Berger, Kenneth I, Goldring, Roberta M, Koralov, Sergei B, Weiden, Michael D, Xiao, Rui, D'Armiento, Jeanine, Clemente, Jose C, Ghedin, Elodie, Segal, Leopoldo N

“…Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and healthcare costs. Cigarette smoke is a causative factor;…”
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Lung microbial and host genomic signatures as predictors of prognosis in early-stage adenocarcinoma by Tsay, Jun-Chieh J, Darawshy, Fares, Wang, Chan, Kwok, Benjamin, Wong, Kendrew K, Wu, Benjamin G, Sulaiman, Imran, Zhou, Hua, Isaacs, Bradley, Kugler, Matthias C, Sanchez, Elizabeth, Bain, Alexander, Li, Yonghua, Schluger, Rosemary, Lukovnikova, Alena, Collazo, Destiny, Kyeremateng, Yaa, Pillai, Ray, Chang, Miao, Li, Qingsheng, Vanguri, Rami S, Becker, Anton S, Moore, William H, Thurston, George, Gordon, Terry, Moreira, Andre L, Goparaju, Chandra M, Sterman, Daniel H, Tsirigos, Aristotelis, Li, Huilin, Segal, Leopoldo N, Pass, Harvey I

“…Risk of early-stage lung adenocarcinoma (LUAD) recurrence after surgical resection is significant, and post-recurrence median survival is approximately two…”
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TGFβ-2 haploinsufficiency causes early death in mice with Marfan syndrome by Sachan, Nalani, Phoon, Colin K.L., Zilberberg, Lior, Kugler, Matthias C., Ene, Taylor, Mintz, Shana B., Murtada, Sae-Il, Weiss, Dar, Fishman, Glenn I., Humphrey, Jay D., Rifkin, Daniel B.

“…•TGF beta2 heterozygosity synergizes with fibrillin1 hypomorphism to cause early death in mice.•Death is not from dissection and rupture.•Mortality is…”
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Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation by Natalini, Jake G, Wong, Kendrew K, Nelson, Nathaniel C, Wu, Benjamin G, Rudym, Darya, Lesko, Melissa B, Qayum, Seema, Lewis, Tyler C, Wong, Adrian, Chang, Stephanie H, Chan, Justin C Y, Geraci, Travis C, Li, Yonghua, Wang, Chan, Li, Huilin, Pamar, Prerna, Schnier, Joseph, Mahoney, Ian J, Malik, Tahir, Darawshy, Fares, Sulaiman, Imran, Kugler, Matthias C, Singh, Rajbir, Collazo, Destiny E, Chang, Miao, Patel, Shrey, Kyeremateng, Yaa, McCormick, Colin, Barnett, Clea R, Tsay, Jun-Chieh J, Brosnahan, Shari B, Singh, Shivani, Pass, Harvey I, Angel, Luis F, Segal, Leopoldo N

“…Acute cellular rejection (ACR) after lung transplant is a leading risk factor for chronic lung allograft dysfunction. Prior studies have demonstrated dynamic…”
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Sonic Hedgehog Signaling in the Lung. From Development to Disease by Kugler, Matthias C., Joyner, Alexandra L., Loomis, Cynthia A., Munger, John S.

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Lung Allograft Dysbiosis Associates with Immune Response and Primary Graft Dysfunction by Nelson, Nathaniel C., Wong, Kendrew K., Mahoney, Ian J., Malik, Tahir, Rudym, Darya, Lesko, Melissa B., Qayum, Seema, Lewis, Tyler C., Chang, Stephanie H., Chan, Justin C.Y., Geraci, Travis C., Li, Yonghua, Pamar, Prerna, Schnier, Joseph, Singh, Rajbir, Collazo, Destiny, Chang, Miao, Kyeremateng, Yaa, McCormick, Colin, Borghi, Sara, Patel, Shrey, Darawshi, Fares, Barnett, Clea R., Sulaiman, Imran, Kugler, Matthias C., Brosnahan, Shari B., Singh, Shivani, Tsay, Jun-Chieh J., Wu, Benjamin G., Pass, Harvey I., Angel, Luis F., Segal, Leopoldo N., Natalini, Jake G.

“…Lower airway enrichment with oral commensals has been previously associated with grade 3 severe primary graft dysfunction (PGD) after lung transplantation…”
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Hedgehog signaling in neonatal and adult lung by Liu, Li, Kugler, Matthias C, Loomis, Cynthia A, Samdani, Rashmi, Zhao, Zhicheng, Chen, Gregory J, Brandt, Julia P, Brownell, Isaac, Joyner, Alexandra L, Rom, William N, Munger, John S

“…Sonic Hedgehog (Shh) signaling is essential during embryonic lung development, but its role in postnatal lung development and adult lung are not known. Using…”
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Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells by Wei, Ying, Tang, Chi-Hui, Kim, Young, Robillard, Liliane, Zhang, Feng, Kugler, Matthias C, Chapman, Harold A

“…Up-regulation of urokinase receptors is common during tumor progression and thought to promote invasion and metastasis. Urokinase receptors bind urokinase and…”
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The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis by Kugler, Matthias C., Yie, Ting-An, Cai, Yi, Berger, Jennifer Z., Loomis, Cynthia A., Munger, John S.

“…Sonic Hedgehog (SHH) signaling, a developmental pathway promoting lung mesenchymal expansion and differentiation during embryogenesis, has been increasingly…”
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Urokinase Receptors Are Required for α5β1 Integrin-mediated Signaling in Tumor Cells by Wei, Ying, Tang, Chi-Hui, Kim, Young, Robillard, Liliane, Zhang, Feng, Kugler, Matthias C., Chapman, Harold A.

“…Up-regulation of urokinase receptors is common during tumor progression and thought to promote invasion and metastasis. Urokinase receptors bind urokinase and…”
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Urokinase receptor and integrin interactions by Kugler, Matthias C, Wei, Ying, Chapman, Harold A

“…Urokinase receptors (uPAR) were initially thought to function simply as a mechanism to concentrate the urokinase/plasmin system toward the cell surface…”
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