Search Results - "Kugener, Guillaume"

Mitochondrial metabolism promotes adaptation to proteotoxic stress by Tsvetkov, Peter, Detappe, Alexandre, Cai, Kai, Keys, Heather R., Brune, Zarina, Ying, Weiwen, Thiru, Prathapan, Reidy, Mairead, Kugener, Guillaume, Rossen, Jordan, Kocak, Mustafa, Kory, Nora, Tsherniak, Aviad, Santagata, Sandro, Whitesell, Luke, Ghobrial, Irene M., Markley, John L., Lindquist, Susan, Golub, Todd R.

“…The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key to understanding how tumor cells, particularly in vivo, are largely…”
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Genetic and transcriptional evolution alters cancer cell line drug response by Ben-David, Uri, Siranosian, Benjamin, Ha, Gavin, Tang, Helen, Oren, Yaara, Hinohara, Kunihiko, Strathdee, Craig A., Dempster, Joshua, Lyons, Nicholas J., Burns, Robert, Nag, Anwesha, Kugener, Guillaume, Cimini, Beth, Tsvetkov, Peter, Maruvka, Yosef E., O’Rourke, Ryan, Garrity, Anthony, Tubelli, Andrew A., Bandopadhayay, Pratiti, Tsherniak, Aviad, Vazquez, Francisca, Wong, Bang, Birger, Chet, Ghandi, Mahmoud, Thorner, Aaron R., Bittker, Joshua A., Meyerson, Matthew, Getz, Gad, Beroukhim, Rameen, Golub, Todd R.

“…Human cancer cell lines are the workhorse of cancer research. Although cell lines are known to evolve in culture, the extent of the resultant genetic and…”
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Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration by McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad

“…The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for…”
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Expert surgeons and deep learning models can predict the outcome of surgical hemorrhage from 1 min of video by Pangal, Dhiraj J., Kugener, Guillaume, Zhu, Yichao, Sinha, Aditya, Unadkat, Vyom, Cote, David J., Strickland, Ben, Rutkowski, Martin, Hung, Andrew, Anandkumar, Animashree, Han, X. Y., Papyan, Vardan, Wrobel, Bozena, Zada, Gabriel, Donoho, Daniel A.

“…Major vascular injury resulting in uncontrolled bleeding is a catastrophic and often fatal complication of minimally invasive surgery. At the outset of these…”
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Neural network modeling for prediction of recurrence, progression, and hormonal non-remission in patients following resection of functional pituitary adenomas by Shahrestani, Shane, Cardinal, Tyler, Micko, Alexander, Strickland, Ben A., Pangal, Dhiraj J., Kugener, Guillaume, Weiss, Martin H., Carmichael, John, Zada, Gabriel

“…Purpose Functional pituitary adenomas (FPAs) cause severe neuro-endocrinopathies including Cushing’s disease (CD) and acromegaly. While many are effectively…”
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An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML by Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K, Seong, Bo Kyung A, Dharia, Neekesh V, Kuljanin, Miljan, Wechsler, Caroline S, Kugener, Guillaume, Robichaud, Amanda L, Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A, Mancias, Joseph D, Younger, Scott T, Piccioni, Federica, Lee, Lynn H, Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly

“…CRISPR-Cas9-based genetic screens have successfully identified cell type-dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating…”
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MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors by Howard, Thomas P, Arnoff, Taylor E, Song, Melinda R, Giacomelli, Andrew O, Wang, Xiaofeng, Hong, Andrew L, Dharia, Neekesh V, Wang, Su, Vazquez, Francisca, Pham, Minh-Tam, Morgan, Ann M, Wachter, Franziska, Bird, Gregory H, Kugener, Guillaume, Oberlick, Elaine M, Rees, Matthew G, Tiv, Hong L, Hwang, Justin H, Walsh, Katherine H, Cook, April, Krill-Burger, John M, Tsherniak, Aviad, Gokhale, Prafulla C, Park, Peter J, Stegmaier, Kimberly, Walensky, Loren D, Hahn, William C, Roberts, Charles W M

“…Malignant rhabdoid tumors (MRT) are highly aggressive pediatric cancers that respond poorly to current therapies. In this study, we screened several MRT cell…”
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Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine by Howard, Thomas P, Oberlick, Elaine M, Rees, Matthew G, Arnoff, Taylor E, Pham, Minh-Tam, Brenan, Lisa, DoCarmo, Mariana, Hong, Andrew L, Kugener, Guillaume, Chou, Hsien-Chao, Drosos, Yiannis, Mathias, Kaeli M, Ramos, Pilar, Seashore-Ludlow, Brinton, Giacomelli, Andrew O, Wang, Xiaofeng, Freeman, 3rd, Burgess B, Blankenship, Kaley, Hoffmann, Lauren, Tiv, Hong L, Gokhale, Prafulla C, Johannessen, Cory M, Stewart, Elizabeth A, Schreiber, Stuart L, Hahn, William C, Roberts, Charles W M

“…Rhabdoid tumors are devastating pediatric cancers in need of improved therapies. We sought to identify small molecules that exhibit and efficacy against…”
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The SAFE-T assessment tool: derivation and validation of a web-based application for point-of-care evaluation of gastroenterology fellow performance in colonoscopy by Kumar, Navin L., MD, Kugener, Guillaume, BS, Perencevich, Molly L., MD, Saltzman, John R., MD

“…Background and Aims Attending assessment is a critical part of endoscopic education for gastroenterology fellows. The aim of this study was to develop and…”
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Simulated outcomes for durotomy repair in minimally invasive spine surgery by Balu, Alan, Kugener, Guillaume, Pangal, Dhiraj J., Lee, Heewon, Lasky, Sasha, Han, Jane, Buchanan, Ian, Liu, John, Zada, Gabriel, Donoho, Daniel A.

“…Minimally invasive spine surgery (MISS) is increasingly performed using endoscopic and microscopic visualization, and the captured video can be used for…”
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Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition by Hong, Andrew L, Tseng, Yuen-Yi, Wala, Jeremiah A, Kim, Won-Jun, Kynnap, Bryan D, Doshi, Mihir B, Kugener, Guillaume, Sandoval, Gabriel J, Howard, Thomas P, Li, Ji, Yang, Xiaoping, Tillgren, Michelle, Ghandi, Mahmhoud, Sayeed, Abeer, Deasy, Rebecca, Ward, Abigail, McSteen, Brian, Labella, Katherine M, Keskula, Paula, Tracy, Adam, Connor, Cora, Clinton, Catherine M, Church, Alanna J, Crompton, Brian D, Janeway, Katherine A, Van Hare, Barbara, Sandak, David, Gjoerup, Ole, Bandopadhayay, Pratiti, Clemons, Paul A, Schreiber, Stuart L, Root, David E, Gokhale, Prafulla C, Chi, Susan N, Mullen, Elizabeth A, Roberts, Charles Wm, Kadoch, Cigall, Beroukhim, Rameen, Ligon, Keith L, Boehm, Jesse S, Hahn, William C

“…Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. We have developed faithful…”
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Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress by Tsvetkov, Peter, Detappe, Alexandre, Cai, Kai, Keys, Heather R., Brune, Zarina, Ying, Weiwen, Thiru, Prathapan, Reidy, Mairead, Kugener, Guillaume, Rossen, Jordan, Kocak, Mustafa, Kory, Nora, Tsherniak, Aviad, Santagata, Sandro, Whitesell, Luke, Ghobrial, Irene M., Markley, John L., Lindquist, Susan, Golub, Todd R.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Caught in the act: Allergic-like reaction to gadolinium-based contrast agent in POEMS syndrome by Kugener, Guillaume, Rajamohan, Anandh, Patel, Vishal

“…POEMS syndrome is a rare paraneoplastic condition related to an abnormal proliferation of plasma cells. Allergic-type reactions to gadolinium-based MR contrast…”
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Haplotype-resolved germline and somatic alterations in renal medullary carcinomas by Tan, Kar-Tong, Kim, Hyunji, Carrot-Zhang, Jian, Zhang, Yuxiang, Kim, Won Jun, Kugener, Guillaume, Wala, Jeremiah A, Howard, Thomas P, Chi, Yueh-Yun, Beroukhim, Rameen, Li, Heng, Ha, Gavin, Alper, Seth L, Perlman, Elizabeth J, Mullen, Elizabeth A, Hahn, William C, Meyerson, Matthew, Hong, Andrew L

“…Renal medullary carcinomas (RMCs) are rare kidney cancers that occur in adolescents and young adults of African ancestry. Although RMC is associated with the…”
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317 Pilot Analysis of Surgeon Instrument Utilization Signatures Based on Shannon Entropy for Surgeon Performance Assessment in a Cadaveric Carotid Artery Injury Control Simulation by Balu, Alan, Pangal, Dhiraj J., Kugener, Guillaume, Donoho, Daniel

“…INTRODUCTION: Automated video-based feedback for a surgeon’s technical skills would improve patient care and facilitate trainee education, but current feedback…”
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APPROACH TO MANAGEMENT OF PATIENTS AT HIGH BLEEDING RISK WITH MITRAL REGURGITATION REQUIRING TRANSCATHETER EDGE TO EDGE MITRAL VALVE REPAIR WITH THE MITRACLIP SYSTEM by Mandava, Sri, Kugener, Guillaume G., Nguyen, Hoang, Aragon, Joseph R.

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In Reply: Deep Neural Networks Can Accurately Detect Blood Loss and Hemorrhage Control Task Success from Video by Kugener, Guillaume, Pangal, Dhiraj J, Donoho, Daniel A

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213 DERIVATION AND VALIDATION OF THE SAFE-T UPPER ENDOSCOPY EVALUATION TOOL: A WEB-BASED SMARTPHONE APPLICATION FOR EVALUATION OF GASTROENTEROLOGY FELLOW PERFORMANCE IN UPPER ENDOSCOPY by Kumar, Navin L., Kugener, Guillaume, Perencevich, Molly, Saltzman, John R.

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A Guide to Annotation of Neurosurgical Intraoperative Video for Machine Learning Analysis and Computer Vision by Pangal, Dhiraj J., Kugener, Guillaume, Shahrestani, Shane, Attenello, Frank, Zada, Gabriel, Donoho, Daniel A.

“…Computer vision (CV) is a subset of artificial intelligence that performs computations on image or video data, permitting the quantitative analysis of visual…”
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Improved surgeon performance following cadaveric simulation of internal carotid artery injury during endoscopic endonasal surgery: training outcomes of a nationwide prospective educational intervention by Donoho, Daniel A, Pangal, Dhiraj J, Kugener, Guillaume, Rutkowski, Martin, Micko, Alexander, Shahrestani, Shane, Brunswick, Andrew, Minneti, Michael, Wrobel, Bozena B, Zada, Gabriel

“…Internal carotid artery injury (ICAI) is a rare, life-threatening complication of endoscopic endonasal approaches that will be encountered by most skull base…”
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