Search Results - "Kugelman, Jeffrey R."

Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo by Kugelman, Jeffrey R, Johnston, Sara C, Mulembakani, Prime M, Kisalu, Neville, Lee, Michael S, Koroleva, Galina, McCarthy, Sarah E, Gestole, Marie C, Wolfe, Nathan D, Fair, Joseph N, Schneider, Bradley S, Wright, Linda L, Huggins, John, Whitehouse, Chris A, Wemakoy, Emile Okitolonda, Muyembe-Tamfum, Jean Jacques, Hensley, Lisa E, Palacios, Gustavo F, Rimoin, Anne W

“…Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic…”
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Evolution and Spread of Ebola Virus in Liberia, 2014–2015 by Ladner, Jason T., Wiley, Michael R., Mate, Suzanne, Dudas, Gytis, Prieto, Karla, Lovett, Sean, Nagle, Elyse R., Beitzel, Brett, Gilbert, Merle L., Fakoli, Lawrence, Diclaro, Joseph W., Schoepp, Randal J., Fair, Joseph, Kuhn, Jens H., Hensley, Lisa E., Park, Daniel J., Sabeti, Pardis C., Rambaut, Andrew, Sanchez-Lockhart, Mariano, Bolay, Fatorma K., Kugelman, Jeffrey R., Palacios, Gustavo

“…The 2013–present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome…”
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Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail by Kugelman, Jeffrey R., Kugelman-Tonos, Johanny, Ladner, Jason T., Pettit, James, Keeton, Carolyn M., Nagle, Elyse R., Garcia, Karla Y., Froude, Jeffrey W., Kuehne, Ana I., Kuhn, Jens H., Bavari, Sina, Zeitlin, Larry, Dye, John M., Olinger, Gene G., Sanchez-Lockhart, Mariano, Palacios, Gustavo F.

“…MB-003, a plant-derived monoclonal antibody cocktail used effectively in treatment of Ebola virus infection in non-human primates, was unable to protect two of…”
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Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia by Kugelman, Jeffrey R, Wiley, Michael R, Mate, Suzanne, Ladner, Jason T, Beitzel, Brett, Fakoli, Lawrence, Taweh, Fahn, Prieto, Karla, Diclaro, Joseph W, Minogue, Timothy, Schoepp, Randal J, Schaecher, Kurt E, Pettitt, James, Bateman, Stacey, Fair, Joseph, Kuhn, Jens H, Hensley, Lisa, Park, Daniel J, Sabeti, Pardis C, Sanchez-Lockhart, Mariano, Bolay, Fatorma K, Palacios, Gustavo

“…To support Liberia's response to the ongoing Ebola virus (EBOV) disease epidemic in Western Africa, we established in-country advanced genomic capabilities to…”
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Error baseline rates of five sample preparation methods used to characterize RNA virus populations by Kugelman, Jeffrey R, Wiley, Michael R, Nagle, Elyse R, Reyes, Daniel, Pfeffer, Brad P, Kuhn, Jens H, Sanchez-Lockhart, Mariano, Palacios, Gustavo F

“…Individual RNA viruses typically occur as populations of genomes that differ slightly from each other due to mutations introduced by the error-prone viral…”
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Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics by Kugelman, Jeffrey R, Sanchez-Lockhart, Mariano, Andersen, Kristian G, Gire, Stephen, Park, Daniel J, Sealfon, Rachel, Lin, Aaron E, Wohl, Shirlee, Sabeti, Pardis C, Kuhn, Jens H, Palacios, Gustavo F

“…Until recently, Ebola virus (EBOV) was a rarely encountered human pathogen that caused disease among small populations with extraordinarily high lethality. At…”
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Japanese Encephalitis Virus Surveillance in U.S. Army Installations in the Republic of Korea from 2021 to 2023 by Lado, Paula, Crispell, Gary P, Chong, Sung Tae, Kim, Myong Sun, Esparza, Ashley N, Zielinski, Eric, Iwami, Akira, Williams, Kelly P, Eads, John J, Jimbo, Kei, Mitzel, Dana N, Cohnstaedt, Lee W, Richardson, Joshua B, Kugelman, Jeffrey R, Stoops, Craig A

“…Japanese encephalitis is a disease caused by the Japanese encephalitis virus (JEV) and is a concern for U.S. military personnel stationed in the Republic of…”
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Informing the Historical Record of Experimental Nonhuman Primate Infections with Ebola Virus: Genomic Characterization of USAMRIID Ebola Virus/H.sapiens-tc/COD/1995/Kikwit-9510621 Challenge Stock "R4368" and Its Replacement "R4415" by Kugelman, Jeffrey R, Rossi, Cynthia A, Wiley, Michael R, Ladner, Jason T, Nagle, Elyse R, Pfeffer, Bradley P, Garcia, Karla, Prieto, Karla, Wada, Jiro, Kuhn, Jens H, Palacios, Gustavo

“…The creation of licensed medical countermeasures against Select Agents such as Ebola virus (EBOV) is critically dependent on the use of standardized reagents,…”
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A Department of Defense Laboratory Consortium Approach to Next Generation Sequencing and Bioinformatics Training for Infectious Disease Surveillance in Kenya by Maljkovic Berry, Irina, Rutvisuttinunt, Wiriya, Voegtly, Logan J, Prieto, Karla, Pollett, Simon, Cer, Regina Z, Kugelman, Jeffrey R, Bishop-Lilly, Kimberly A, Morton, Lindsay, Waitumbi, John, Jarman, Richard G

“…Epidemics of emerging and re-emerging infectious diseases are a danger to civilian and military populations worldwide. Health security and mitigation of…”
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Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection by Kugelman, Jeffrey R, Lee, Michael S, Rossi, Cynthia A, McCarthy, Sarah E, Radoshitzky, Sheli R, Dye, John M, Hensley, Lisa E, Honko, Anna, Kuhn, Jens H, Jahrling, Peter B, Warren, Travis K, Whitehouse, Chris A, Bavari, Sina, Palacios, Gustavo

“…To identify polymorphic sites that could be used as biomarkers of Ebola virus passage history, we repeatedly amplified Ebola virus (Kikwit variant) in vitro…”
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On-Demand Patient-Specific Phenotype-to-Genotype Ebola Virus Characterization by Beitzel, Brett F, Radoshitzky, Sheli R, Di Paola, Nicholas, Brannan, Jennifer M, Kimmel, David, Caviness, Katie, Soloveva, Veronica, Yu, Shuiqing, Postnikova, Elena N, Finch, Courtney L, Liu, Hu, Prugar, Laura, Bakken, Russell, Dye, John M, Kugelman, Jeffrey R, Cunningham, James M, Sanchez-Lockhart, Mariano, Kuhn, Jens H, Palacios, Gustavo

“…Biosafety, biosecurity, logistical, political, and technical considerations can delay or prevent the wide dissemination of source material containing viable…”
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SUMOylation of the Lens Epithelium-Derived Growth Factor/p75 Attenuates Its Transcriptional Activity on the Heat Shock Protein 27 Promoter by Bueno, Murilo T.D., Garcia-Rivera, Jose A., Kugelman, Jeffrey R., Morales, Elisa, Rosas-Acosta, Germán, Llano, Manuel

“…Lens epithelium-derived growth factor (LEDGF) proteins p75 and p52 are transcriptional coactivators that connect sequence-specific activators to the basal…”
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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys by Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina

“…The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of…”
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Implication of Serine Residues 271, 273, and 275 in the Human Immunodeficiency Virus Type 1 Cofactor Activity of Lens Epithelium-Derived Growth Factor/p75 by Garcia-Rivera, Jose A, Bueno, Murilo T D, Morales, Elisa, Kugelman, Jeffrey R, Rodriguez, Daniel F, Llano, Manuel

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone by Park, Daniel J., Dudas, Gytis, Wohl, Shirlee, Goba, Augustine, Whitmer, Shannon L.M., Andersen, Kristian G., Sealfon, Rachel S., Ladner, Jason T., Kugelman, Jeffrey R., Matranga, Christian B., Winnicki, Sarah M., Qu, James, Gire, Stephen K., Gladden-Young, Adrianne, Jalloh, Simbirie, Nosamiefan, Dolo, Yozwiak, Nathan L., Moses, Lina M., Jiang, Pan-Pan, Lin, Aaron E., Schaffner, Stephen F., Bird, Brian, Towner, Jonathan, Mamoh, Mambu, Gbakie, Michael, Kanneh, Lansana, Kargbo, David, Massally, James L.B., Kamara, Fatima K., Konuwa, Edwin, Sellu, Josephine, Jalloh, Abdul A., Mustapha, Ibrahim, Foday, Momoh, Yillah, Mohamed, Erickson, Bobbie R., Sealy, Tara, Blau, Dianna, Paddock, Christopher, Brault, Aaron, Amman, Brian, Basile, Jane, Bearden, Scott, Belser, Jessica, Bergeron, Eric, Campbell, Shelley, Chakrabarti, Ayan, Dodd, Kimberly, Flint, Mike, Gibbons, Aridth, Goodman, Christin, Klena, John, McMullan, Laura, Morgan, Laura, Russell, Brandy, Salzer, Johanna, Sanchez, Angela, Wang, David, Jungreis, Irwin, Tomkins-Tinch, Christopher, Kislyuk, Andrey, Lin, Michael F., Chapman, Sinead, MacInnis, Bronwyn, Matthews, Ashley, Bochicchio, James, Hensley, Lisa E., Kuhn, Jens H., Nusbaum, Chad, Schieffelin, John S., Birren, Bruce W., Forget, Marc, Nichol, Stuart T., Palacios, Gustavo F., Ndiaye, Daouda, Happi, Christian, Gevao, Sahr M., Vandi, Mohamed A., Kargbo, Brima, Holmes, Edward C., Bedford, Trevor, Gnirke, Andreas, Ströher, Ute, Rambaut, Andrew, Garry, Robert F., Sabeti, Pardis C.

“…The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of Ebola virus (EBOV). Early in the epidemic, genome sequencing provided…”
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Reidentification of Ebola Virus E718 and ME as Ebola Virus/H.sapiens-tc/COD/1976/Yambuku-Ecran by Kuhn, Jens H, Lofts, Loreen L, Kugelman, Jeffrey R, Smither, Sophie J, Lever, Mark S, van der Groen, Guido, Johnson, Karl M, Radoshitzky, Sheli R, Bavari, Sina, Jahrling, Peter B, Towner, Jonathan S, Nichol, Stuart T, Palacios, Gustavo

“…Ebola virus (EBOV) was discovered in 1976 around Yambuku, Zaire. A lack of nomenclature standards resulted in a variety of designations for each isolate,…”
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Recent successes in therapeutics for Ebola virus disease: no time for complacency by Iversen, Patrick L, Kane, Christopher D, Zeng, Xiankun, Panchal, Rekha G, Warren, Travis K, Radoshitzky, Sheli R, Kuhn, Jens H, Mudhasani, Rajini R, Cooper, Christopher L, Shurtleff, Amy C, Nasar, Farooq, Sunay, Melek ME, Duplantier, Allen J, Eaton, Brett P, Zumbrun, Elizabeth E, Bixler, Sandra L, Martin, Shannon, Meinig, J Matthew, Chiang, Chih-Yuan, Sanchez-Lockhart, Mariano, Palacios, Gustavo F, Kugelman, Jeffrey R, Martins, Karen A, Pitt, Margaret L, Crozier, Ian, Saunders, David L

“…The PALM trial in the Democratic Republic of the Congo identified a statistically significant survival benefit for two monoclonal antibody-based therapeutics…”
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HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin by Astiazaran, Paulina, Bueno, Murilo Td, Morales, Elisa, Kugelman, Jeffrey R, Garcia-Rivera, Jose A, Llano, Manuel

“…Chromatin binding plays a central role in the molecular mechanism of LEDGF/p75 in HIV-1 DNA integration. Conflicting results have been reported in regards to…”
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Monkeypox virus genomic accordion strategies by Monzón, Sara, Varona, Sarai, Negredo, Anabel, Vidal-Freire, Santiago, Patiño-Galindo, Juan Angel, Ferressini-Gerpe, Natalia, Zaballos, Angel, Orviz, Eva, Ayerdi, Oskar, Muñoz-Gómez, Ana, Delgado-Iribarren, Alberto, Estrada, Vicente, García, Cristina, Molero, Francisca, Sánchez-Mora, Patricia, Torres, Montserrat, Vázquez, Ana, Galán, Juan-Carlos, Torres, Ignacio, Causse del Río, Manuel, Merino-Diaz, Laura, López, Marcos, Galar, Alicia, Cardeñoso, Laura, Gutiérrez, Almudena, Loras, Cristina, Escribano, Isabel, Alvarez-Argüelles, Marta E., del Río, Leticia, Simón, María, Meléndez, María Angeles, Camacho, Juan, Herrero, Laura, Jiménez, Pilar, Navarro-Rico, María Luisa, Jado, Isabel, Giannetti, Elaina, Kuhn, Jens H., Sanchez-Lockhart, Mariano, Di Paola, Nicholas, Kugelman, Jeffrey R., Guerra, Susana, García-Sastre, Adolfo, Cuesta, Isabel, Sánchez-Seco, Maripaz P., Palacios, Gustavo

“…The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person…”
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Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19 by Zumbrun, Elizabeth E, Kaku, Chengzi I, Dillinger, Lukas, Zak, Samantha E, Kuehne, Ana I, Bakken, Russel R, Koehler, Jeffrey W, Delp, Korey L, Stefan, Christopher P, Kumar, Raina, Kugelman, Jeffrey R, Moreau, Alicia M, Zeng, Xiankun, Dye, John M, Herbert, Andrew S, Narayan, Kristin, Walker, Laura M

“…Adintrevimab is a human immunoglobulin G1 monoclonal antibody engineered to have broad neutralization against severe acute respiratory syndrome coronavirus 2…”
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