Search Results - "Kugel, H"

Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group by Westlye, L T, Jahanshad, N, Cheung, J W, Ching, C R K, Versace, A, Bilderbeck, A C, Uhlmann, A, Overs, B, Dima, D, Grotegerd, D, Sprooten, E, Bøen, E, Jimenez, E, Howells, F M, Delvecchio, G, Starke, J, Goikolea, J M, Houenou, J, Beard, L M, Rauer, L, Abramovic, L, Bonnin, M, Ponteduro, M F, Keil, M, Rive, M M, Yao, N, Rosa, P G, Redlich, R, Trost, S, Fears, S C, van Erp, T G M, Nickson, T, Chaim-Avancini, T M, Elvsåshagen, T, Haukvik, U K, Lee, W H, Schene, A H, Lloyd, A J, Young, A H, Nugent, A, Dale, A M, Pfennig, A, Lafer, B, Baune, B T, Ekman, C J, Zarate, C A, Bearden, C E, Henry, C, Simhandl, C, McDonald, C, Bourne, C, Stein, D J, Wolf, D H, Cannon, D M, Glahn, D C, Veltman, D J, Vieta, E, Canales-Rodriguez, E J, Nery, F G, Duran, F L S, Busatto, G F, Roberts, G, Pearlson, G D, Goodwin, G M, Ruhe, H G, Soares, J C, Fullerton, J M, Rybakowski, J K, Chaim, K T, Fatjó-Vilas, M, Soeiro-de-Souza, M G, Boks, M P, Zanetti, M V, Otaduy, M C G, Schaufelberger, M S, Ingvar, M, Phillips, M L, Bauer, M, Landén, M, Lawrence, N S, van Haren, N E M, Horn, N R, Freimer, N B, Schofield, P R, Mitchell, P B, Kahn, R S, Lenroot, R, Machado-Vieira, R, Ophoff, R A, Sarró, S, Frangou, S, Satterthwaite, T D, Hajek, T, Dannlowski, U, Arolt, V, Gattaz, W F, Drevets, W C, Agartz, I, Thompson, P M, Andreassen, O A

“…Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with…”
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Adaptive resistance to RAF inhibitors in melanoma by Kugel III, Curtis H., Aplin, Andrew E.

“…Summary The discovery of activating mutations in BRAF at high frequency in cutaneous melanoma opened the door to new treatment options, which have resulted in…”
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Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3 by Abel, Ethan V, Basile, Kevin J, Kugel, 3rd, Curtis H, Witkiewicz, Agnieszka K, Le, Kaitlyn, Amaravadi, Ravi K, Karakousis, Giorgos C, Xu, Xiaowei, Xu, Wei, Schuchter, Lynn M, Lee, Jason B, Ertel, Adam, Fortina, Paolo, Aplin, Andrew E

“…The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain unclear. By combining ChIP sequencing with microarray-based gene…”
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The Wnts of change: How Wnts regulate phenotype switching in melanoma by Webster, Marie R., Kugel, Curtis H., Weeraratna, Ashani T.

“…The outgrowth of metastatic and therapy-resistant subpopulations in cancer remains a critical barrier for the successful treatment of this disease. In…”
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Neutrophilic myeloid‐derived suppressor cells in cord blood modulate innate and adaptive immune responses by Rieber, N., Gille, C., Köstlin, N., Schäfer, I., Spring, B., Ost, M., Spieles, H., Kugel, H. A., Pfeiffer, M., Heininger, V., Alkhaled, M., Hector, A., Mays, L., Kormann, M., Zundel, S., Fuchs, J., Handgretinger, R., Poets, C. F., Hartl, D.

“…Summary Neonates show an impaired anti‐microbial host defence, but the underlying immune mechanisms are not understood fully. Myeloid‐derived suppressor cells…”
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Diffeomorphic susceptibility artifact correction of diffusion-weighted magnetic resonance images by Ruthotto, L, Kugel, H, Olesch, J, Fischer, B, Modersitzki, J, Burger, M, Wolters, C H

“…Diffusion-weighted magnetic resonance imaging is a key investigation technique in modern neuroscience. In clinical settings, diffusion-weighted imaging and its…”
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Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility by Kaur, Amanpreet, Ecker, Brett L, Douglass, Stephen M, Kugel, 3rd, Curtis H, Webster, Marie R, Almeida, Filipe V, Somasundaram, Rajasekharan, Hayden, James, Ban, Ehsan, Ahmadzadeh, Hossein, Franco-Barraza, Janusz, Shah, Neelima, Mellis, Ian A, Keeney, Frederick, Kossenkov, Andrew, Tang, Hsin-Yao, Yin, Xiangfan, Liu, Qin, Xu, Xiaowei, Fane, Mitchell, Brafford, Patricia, Herlyn, Meenhard, Speicher, David W, Wargo, Jennifer A, Tetzlaff, Michael T, Haydu, Lauren E, Raj, Arjun, Shenoy, Vivek, Cukierman, Edna, Weeraratna, Ashani T

“…Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM)…”
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Differing brain structural correlates of familial and environmental risk for major depressive disorder revealed by a combined VBM/pattern recognition approach by Opel, N, Zwanzger, P, Redlich, R, Grotegerd, D, Dohm, K, Arolt, V, Heindel, W, Kugel, H, Dannlowski, U

“…Neuroimaging traits of either familial or environmental risk for major depressive disorder (MDD) have been interpreted as possibly useful vulnerability…”
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Prefrontal gray matter volume mediates genetic risks for obesity by Opel, N, Redlich, R, Kaehler, C, Grotegerd, D, Dohm, K, Heindel, W, Kugel, H, Thalamuthu, A, Koutsouleris, N, Arolt, V, Teuber, A, Wersching, H, Baune, B T, Berger, K, Dannlowski, U

“…Genetic and neuroimaging research has identified neurobiological correlates of obesity. However, evidence for an integrated model of genetic risk and brain…”
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CADM1 is a TWIST1-regulated suppressor of invasion and survival by Hartsough, Edward J., Weiss, Michele B., Heilman, Shea A., Purwin, Timothy J., Kugel, Curtis H., Rosenbaum, Sheera R., Erkes, Dan A., Tiago, Manoela, HooKim, Kim, Chervoneva, Inna, Aplin, Andrew E.

“…Metastatic cancer remains a clinical challenge; however, patients diagnosed prior to metastatic dissemination have a good prognosis. The transcription factor,…”
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Multimodal imaging of functional networks and event-related potentials in performance monitoring by Huster, R.J., Eichele, T., Enriquez-Geppert, S., Wollbrink, A., Kugel, H., Konrad, C., Pantev, C.

“…The stop-signal task is a prototypical experiment to study cognitive processes that mediate successful performance in a rapidly changing environment. By means…”
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Granulocytic myeloid‐derived suppressor cells (GR‐MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period by Schwarz, J., Scheckenbach, V., Kugel, H., Spring, B., Pagel, J., Härtel, C., Pauluschke‐Fröhlich, J., Peter, A., Poets, C. F., Gille, C., Köstlin, N.

“…Summary Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri‐ or…”
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Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho by Behera, Reeti, Kaur, Amanpreet, Webster, Marie R, Kim, Suyeon, Ndoye, Abibatou, Kugel, 3rd, Curtis H, Alicea, Gretchen M, Wang, Joshua, Ghosh, Kanad, Cheng, Phil, Lisanti, Sofia, Marchbank, Katie, Dang, Vanessa, Levesque, Mitchell, Dummer, Reinhard, Xu, Xiaowei, Herlyn, Meenhard, Aplin, Andrew E, Roesch, Alexander, Caino, Cecilia, Altieri, Dario C, Weeraratna, Ashani T

“…Aging is a poor prognostic factor for melanoma. We have shown that melanoma cells in an aged microenvironment are more resistant to targeted therapy than…”
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SHOC2 and CRAF Mediate ERK1/2 Reactivation in Mutant NRAS-mediated Resistance to RAF Inhibitor by Kaplan, Fred M., Kugel, Curtis H., Dadpey, Neda, Shao, Yongping, Abel, Ethan V., Aplin, Andrew E.

“…ERK1/2 signaling is frequently dysregulated in tumors through BRAF mutation. Targeting mutant BRAF with vemurafenib frequently elicits therapeutic responses;…”
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Neural correlates of trait anxiety in fear extinction by Sehlmeyer, C, Dannlowski, U, Schöning, S, Kugel, H, Pyka, M, Pfleiderer, B, Zwitserlood, P, Schiffbauer, H, Heindel, W, Arolt, V, Konrad, C

“…Fear conditioning involves the amygdala as the main neural structure for learning fear responses whereas fear extinction mainly activates the inhibitory…”
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Effects of electroconvulsive therapy on amygdala function in major depression - a longitudinal functional magnetic resonance imaging study by Redlich, R, Bürger, C, Dohm, K, Grotegerd, D, Opel, N, Zaremba, D, Meinert, S, Förster, K, Repple, J, Schnelle, R, Wagenknecht, C, Zavorotnyy, M, Heindel, W, Kugel, H, Gerbaulet, M, Alferink, J, Arolt, V, Zwanzger, P, Dannlowski, U

“…Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depression. However, little is known regarding brain functional processes…”
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Dehydration confounds the assessment of brain atrophy by DUNING, T, KLOSKA, S, STEINSTRÄTER, O, KUGEL, H, HEINDEL, W, KNECHT, S

“…Computerized brain volumetry has potential value for diagnosis and the follow-up evaluation of degenerative disorders. A potential pitfall of this method is…”
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Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure by Dannlowski, U, Grabe, H J, Wittfeld, K, Klaus, J, Konrad, C, Grotegerd, D, Redlich, R, Suslow, T, Opel, N, Ohrmann, P, Bauer, J, Zwanzger, P, Laeger, I, Hohoff, C, Arolt, V, Heindel, W, Deppe, M, Domschke, K, Hegenscheid, K, Völzke, H, Stacey, D, Meyer zu Schwabedissen, H, Kugel, H, Baune, B T

“…In two large genome-wide association studies, an intergenic single-nucleotide polymorphism (SNP; rs7294919 ) involved in TESC gene regulation has been…”
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Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2 by Alicea, Gretchen M, Rebecca, Vito W, Goldman, Aaron R, Fane, Mitchell E, Douglass, Stephen M, Behera, Reeti, Webster, Marie R, Kugel, 3rd, Curtis H, Ecker, Brett L, Caino, M Cecilia, Kossenkov, Andrew V, Tang, Hsin-Yao, Frederick, Dennie T, Flaherty, Keith T, Xu, Xiaowei, Liu, Qin, Gabrilovich, Dmitry I, Herlyn, Meenhard, Blair, Ian A, Schug, Zachary T, Speicher, David W, Weeraratna, Ashani T

“…Older patients with melanoma (>50 years old) have poorer prognoses and response rates to targeted therapy compared with young patients (<50 years old), which…”
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Functional anatomy of visuo-spatial working memory during mental rotation is influenced by sex, menstrual cycle, and sex steroid hormones by Schöning, S., Engelien, A., Kugel, H., Schäfer, S., Schiffbauer, H., Zwitserlood, P., Pletziger, E., Beizai, P., Kersting, A., Ohrmann, P., Greb, R.R., Lehmann, W., Heindel, W., Arolt, V., Konrad, C.

“…Recent observations indicate that sex and level of steroid hormones may influence cortical networks associated with specific cognitive functions, in particular…”
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