Search Results - "Kugel, F."

XPB, a subunit of TFIIH, is a target of the natural product triptolide by Liu, Jun O, Titov, Denis V, Gilman, Benjamin, He, Qing-Li, Bhat, Shridhar, Low, Woon-Kai, Dang, Yongjun, Smeaton, Michael, Demain, Arnold L, Miller, Paul S, Kugel, Jennifer F, Goodrich, James A

“…Triptolide is a bioactive natural product isolated from plants used in traditional Chinese medicine. A target identification approach shows that triptolide…”
Get full text

Non-coding-RNA regulators of RNA polymerase II transcription by Goodrich, James A, Kugel, Jennifer F

“…Several non-coding RNAs (ncRNAs) that regulate eukaryotic mRNA transcription have recently been discovered. Their mechanisms of action and biological roles are…”
Get full text

Interactions of HMGB Proteins with the Genome and the Impact on Disease by Voong, Calvin K, Goodrich, James A, Kugel, Jennifer F

“…High Mobility Group Box (HMGB) proteins are small architectural DNA binding proteins that regulate multiple genomic processes such as DNA damage repair,…”
Get full text

B2 RNA and Alu RNA Repress Transcription by Disrupting Contacts between RNA Polymerase II and Promoter DNA within Assembled Complexes by Yakovchuk, Petro, Goodrich, James A., Kugel, Jennifer F., Roeder, Robert G.

“…Noncoding RNAs (ncRNAs) are now recognized as transregulators of eukaryotic transcription, a role once attributed exclusively to protein factors. Two ncRNAs in…”
Get full text

Finding the start site: redefining the human initiator element by Kugel, Jennifer F, Goodrich, James A

“…Transcription by RNA polymerase II (Pol II) is dictated in part by core promoter elements, which are DNA sequences flanking the transcription start site (TSS)…”
Get full text

Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements by Suwita, Johannes P, Voong, Calvin K, Ly, Elina, Goodrich, James A, Kugel, Jennifer F

“…The transcriptional activator p53 is a tumor suppressor protein that controls cellular pathways important for cell fate decisions, including cell cycle arrest,…”
Get full text

Mechanisms and Functions of the RNA Polymerase II General Transcription Machinery during the Transcription Cycle by Archuleta, Stephen R, Goodrich, James A, Kugel, Jennifer F

“…Central to the development and survival of all organisms is the regulation of gene expression, which begins with the process of transcription catalyzed by RNA…”
Get full text

The HMGB1 C-Terminal Tail Regulates DNA Bending by Blair, Rebecca H., Horn, Abigail E., Pazhani, Yogitha, Grado, Lizbeth, Goodrich, James A., Kugel, Jennifer F.

“…High mobility group box protein 1 (HMGB1) is an architectural protein that facilitates the formation of protein–DNA assemblies involved in transcription,…”
Get full text

Short‐term exposure to ethanol induces transcriptional changes in nontumorigenic breast cells by Miller, Georgiana M., Brant, Tyler S., Goodrich, James A., Kugel, Jennifer F.

“…Breast cancer is a leading cause of cancer‐related deaths in women. Many genetic and behavioral risk factors can contribute to the initiation and progression…”
Get full text

ERK1/2 activation is a therapeutic target in age-related macular degeneration by Dridi, Sami, Hirano, Yoshio, Tarallo, Valeria, Kim, Younghee, Fowler, Benjamin J, Ambati, Balamurali K, Bogdanovich, Sasha, Chiodo, Vince A, Hauswirth, William W, Kugel, Jennifer F, Goodrich, James A, Ponicsan, Steven L, Hinton, David R, Kleinman, Mark E, Baffi, Judit Z, Gelfand, Bradley D, Ambati, Jayakrishna

“…Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal…”
Get full text

B2 RNA binds directly to RNA polymerase II to repress transcript synthesis by Kugel, Jennifer F, Goodrich, James A, Espinoza, Celso A, Allen, Tiffany A, Hieb, Aaron R

“…B2 RNA is a small noncoding RNA polymerase III transcript that represses mRNA transcription in response to heat shock in mouse cells. Here we define the…”
Get full text

Comets beyond 4 au: How pristine are Oort nuclei? by Fulle, Marco, Lazzarin, M, La Forgia, F, Zakharov, V V, Bertini, I, Mazzotta Epifani, E, Ammannito, E, Buzzoni, A, Capria, M T, Carbognani, A, Da Deppo, V, Della Corte, V, Fiscale, S, Frattin, E, Inno, L, Migliorini, A, Pernechele, C, Rotundi, A, Sindoni, G, Tubiana, C, Milani, G, Aletti, A, Bacci, P, Baj, G, Bellini, F, Bryssinck, E, Di Grazia, M, Facchini, M, Feraco, M, Guido, E, Ligustri, R, Kugel, F, Maestripieri, M, Tirelli, D, Valvasori, A, Snodgrass, C, Jones, G H

“…ABSTRACT The ESA mission Comet Interceptor will target an Oort or interstellar comet during its first approach to the Sun. Meanwhile, the Vera Rubin LSST…”
Get full text

Using electrophoretic mobility shift assays to measure equilibrium dissociation constants: GAL4‐p53 binding DNA as a model system by Heffler, Michael A., Walters, Ryan D., Kugel‡, Jennifer F.

“…An undergraduate biochemistry laboratory experiment is described that will teach students the practical and theoretical considerations for measuring the…”
Get full text

Characterization of the structure, function, and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription by Espinoza, Celso A, Goodrich, James A, Kugel, Jennifer F

“…We previously found that the SINE-encoded mouse B2 RNA binds RNA polymerase II and represses mRNA transcription during the cellular heat-shock response. In…”
Get full text

Historical vanishing of the Blazhko effect of RR Lyr from the GEOS and Kepler surveys by Le Borgne, J. F., Poretti, E., Klotz, A., Denoux, E., Smith, H. A., Kolenberg, K., Szabó, R., Bryson, S., Audejean, M., Buil, C., Caron, J., Conseil, E., Corp, L., Drillaud, C., de France, T., Graham, K., Hirosawa, K., Klotz, A. N., Kugel, F., Loughney, D., Menzies, K., Rodríguez, M., Ruscitti, P. M.

“…RR Lyr is one of the most studied variable stars. Its light curve has been regularly monitored since the discovery of its periodic variability in 1899. The…”
Get full text

Evaluating the Relationship between FRET Changes and Distance Changes Using DNA Length and Restriction Enzyme Specificity by Pazhani, Yogitha, Horn, Abigail E, Grado, Lizbeth, Kugel, Jennifer F

“…FRET (Förster resonance energy transfer) involves the transfer of energy from an excited donor fluorophore to an acceptor molecule in a manner that is…”
Get full text

GRB 110205A: ANATOMY OF A LONG GAMMA-RAY BURST by GENDRE, B, ATTEIA, J. L, VACHIER, F, BOËR, M, COLAS, F, KLOTZ, A, KUGEL, F, LAAS-BOUREZ, M, RINNER, C, STRAJNIC, J, STRATTA, G

“…The Swift burst GRB 110205A was a very bright burst visible in the Northern Hemisphere. GRB 110205A was intrinsically long and very energetic and it occurred…”
Get full text

Selection and characterization of a DNA aptamer that can discriminate between cJun/cJun and cJun/cFos by Walters, Ryan D, McSwiggen, David T, Goodrich, James A, Kugel, Jennifer F

“…The AP-1 family of transcriptional activators plays pivotal roles in regulating a wide range of biological processes from the immune response to tumorigenesis…”
Get full text

The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock by Goodrich, James A, Kugel, Jennifer F, Allen, Tiffany A, Von Kaenel, Sandra

“…Cells respond to changes in environmental conditions via orchestrated modifications in gene expression. For example, in response to heat shock, cells execute a…”
Get full text

TFIIF Facilitates Dissociation of RNA Polymerase II from Noncoding RNAs That Lack a Repression Domain by Wagner, Stacey D., Kugel, Jennifer F., Goodrich, James A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text