Search Results - "Kugathasan, S."

The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease – a phase 1 trial with three doses by Dhere, T., Copland, I., Garcia, M., Chiang, K. Y., Chinnadurai, R., Prasad, M., Galipeau, J., Kugathasan, S.

“…Summary Background Mesenchymal stromal cells ability to reset immune functionalities may be useful in Crohn's disease. Aim To perform a first‐in‐human phase 1…”
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NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease by Schwerd, T, Bryant, R V, Pandey, S, Capitani, M, Meran, L, Cazier, J-B, Jung, J, Mondal, K, Parkes, M, Mathew, C G, Fiedler, K, McCarthy, D J, Sullivan, P B, Rodrigues, A, Travis, S P L, Moore, C, Sambrook, J, Ouwehand, W H, Roberts, D J, Danesh, J, Russell, R K, Wilson, D C, Kelsen, J R, Cornall, R, Denson, L A, Kugathasan, S, Knaus, U G, Serra, E G, Anderson, C A, Duerr, R H, McGovern, D PB, Cho, J, Powrie, F, Li, V SW, Muise, A M, Uhlig, H H

“…Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome…”
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Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease by Kugathasan, S, Saubermann, L J, Smith, L, Kou, D, Itoh, J, Binion, D G, Levine, A D, Blumberg, R S, Fiocchi, C

“…Background and aims:Crohn’s disease is a life-long form of inflammatory bowel disease (IBD) mediated by mucosal immune abnormalities. Understanding of the…”
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African Ancestry Proportion Influences Ileal Gene Expression in Inflammatory Bowel Disease by Mo, A., Krishnakumar, C., Arafat, D., Dhere, T., Iskandar, H., Dodd, A., Prince, J., Kugathasan, S., Gibson, G.

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Complexity of Secretory Chemokines in Human Intestinal Organoid Cultures Ex Vivo by Cottle, C., Anbazhagan, M., Lipat, A., Patel, M., Porter, A.P., Hogan, K., Rajan, D., Matthews, J.D., Kugathasan, S., Chinnadurai, R.

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Crohn's Disease and Genetic Hitchhiking at IBD5 by Huff, Chad D., Witherspoon, David J., Zhang, Yuhua, Gatenbee, Chandler, Denson, Lee A., Kugathasan, Subra, Hakonarson, Hakon, Whiting, April, Davis, Chadwick T., Wu, Wilfred, Xing, Jinchuan, Watkins, W. Scott, Bamshad, Michael J., Bradfield, Jonathan P., Bulayeva, Kazima, Simonson, Tatum S., Jorde, Lynn B., Guthery, Stephen L.

“…Inflammatory bowel disease 5 (IBD5) is a 250 kb haplotype on chromosome 5 that is associated with an increased risk of Crohn's disease in Europeans. The OCTN1…”
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Safety and Efficacy of Autologous and Metabolically Fit Bone Marrow Mesenchymal Stromal Cells (BM-MSC) in Medically Refractory Crohn's Disease (CD) by Dhere, T, Copland, I, Chiang, K, Garcia, M, Chinnadurai, R, Chikkabbagilu, M, Galipeau, J, Kugathasan, S

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Genetic variants in the autophagy pathway contribute to paediatric Crohn's disease by Peterson, N, Guthery, S, Denson, L, Lee, J, Saeed, S, Prahalad, S, Biank, V, Ehlert, R, Tomer, G, Grand, R, Rudolph, C, Kugathasan, S

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Prolonged Duration of Response to Infliximab in Early Pediatric Crohnʼs Disease by Kugathasan, Subra

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Percutaneous colonoscopic cecostomy for management of chronic constipation in children by Rivera, Maria T., Kugathasan, Subra, Berger, William, Werlin, Steven L.

“…Background: Chronic constipation and encopresis are common problems in children with spina bifida and anorectal anomalies. Commonly used therapies include…”
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Improvement in a biomarker of bone formation during infliximab therapy in pediatric Crohn disease: Results of the REACH study by Thayu, M, Leonard, M, Hyams, J, Crandall, W, Kugathasan, S, Otley, A, Olsen, A, Xu, S, Marano, C, Heuschkel, R, Veereman-Wauters, G, Griffiths, A, Baldassano, R, REACH Study Group

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Pediatric inflammatory bowel disease: clinical and therapeutic aspects by Kugathasan, Subra

“…Epidemiologic data suggest that the incidences of pediatric ulcerative colitis and Crohn disease continue to evolve with geographic variations. One study…”
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MMR and IBD: the only thing we have to fear is...fear itself by Kugathasan, S

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Measurement of pANCA (antineutrophil cytoplasmic antibodies) and ASCA (anti-saccharomyces cerevisiae) in screening for IBD in young children by Kugathasan, S, Werlin, S L

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A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition by Li, Dalin, Achkar, Jean-Paul, Haritunians, Talin, Jacobs, Jonathan P, Hui, Ken Y, D'Amato, Mauro, Brand, Stephan, Radford-Smith, Graham, Halfvarson, Jonas, Niess, Jan-Hendrik, Kugathasan, Subra, Büning, Carsten, Schumm, L. Philip, Klei, Lambertus, Ananthakrishnan, Ashwin, Aumais, Guy, Baidoo, Leonard, Dubinsky, Marla, Fiocchi, Claudio, Glas, Jürgen, Milgrom, Raquel, Proctor, Deborah D, Regueiro, Miguel, Simms, Lisa A, Stempak, Joanne M, Targan, Stephan R, Törkvist, Leif, Sharma, Yashoda, Devlin, Bernie, Borneman, James, Hakonarson, Hakon, Xavier, Ramnik J, Daly, Mark, Brant, Steven R, Rioux, John D, Silverberg, Mark S, Cho, Judy H, Braun, Jonathan, McGovern, Dermot P.B, Duerr, Richard H

“…Background & Aims Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn’s disease…”
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P115 Ustekinumab in DEVELOP: A safety analysis from an Inflammatory Bowel Disease multicenter, prospective, long-term registry of paediatric patients by Koletzko, S, Veereman, G, Hyams, J, Dubinsky, M, Godwin, B, Busse, C, Strauss, R, Volger, S, Wang, Y, Griffiths, A, Colletti, R B, Kugathasan, S, Markowitz, J, Winter, H S, Escher, J, Baldassano, R N, Ruemmele, F, Faubion, W, Gold, B

“…Abstract Background DEVELOP is a multi-center, global, prospective, observational, longitudinal registry of long-term safety of infliximab (and other…”
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Association Between Plasma Level of Collagen Type III Alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn’s Disease by Ballengee, Cortney R., Stidham, Ryan W., Liu, Chunyan, Kim, Mi-Ok, Prince, Jarod, Mondal, Kajari, Baldassano, Robert, Dubinsky, Marla, Markowitz, James, Leleiko, Neal, Hyams, Jeffrey, Denson, Lee, Kugathasan, Subra

“…There are few serum biomarkers to identify patients with Crohn’s disease (CD) who are at risk for stricture development. The extracellular matrix components,…”
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DISTINCT MUCOSAL T-CELL RESPONSES TO IL-12 IN EARLY AND LATE STAGES OF INFLAMMATORY BOWEL DISEASE (IBD) by Kugathasan, S, Itoh, J, Boyle, J T, Levine, A D, Fiocchi, C

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Pancreatitis in Children by Werlin, Steven L., Kugathasan, Subra, Frautschy, Brenda Cowan

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P089 Long ncRNA Landscape in the Rectum of Treatment Naïve Early Onset Ulcerative Colitis Highlights Association with Severity and Early and Late Disease Outcome, with Potential Role in Epithelial Metabolic Functions by Haberman Ziv, Y, Braun, T, Sosnovski, K, Amir, A, VanDussen, K, Igor Ulitsky, I U, Griffiths, A, Walters, T, Mack, D, Boyle, B, Kugathasan, S, Jegga, A, Hyams, J, Denson, L

“…Abstract Background Long non-coding RNAs (lncRNAs) are tissue-specific and regulate cellular functions. We previously reported a dramatic inhibition of…”
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