Search Results - "Kufeld, Megan"

Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress by Cai, Elise Y., Kufeld, Megan N., Schuster, Samantha, Arora, Sonali, Larkin, Madeline, Germanos, Alexandre A., Hsieh, Andrew C., Beronja, Slobodan

“…Human skin tolerates a surprisingly high burden of oncogenic lesions. Although adult epidermis can suppress the expansion of individual mutant clones, the…”
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Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma by O’Connor, Samantha A, Feldman, Heather M, Arora, Sonali, Hoellerbauer, Pia, Toledo, Chad M, Corrin, Philip, Carter, Lucas, Kufeld, Megan, Bolouri, Hamid, Basom, Ryan, Delrow, Jeffrey, McFaline‐Figueroa, José L, Trapnell, Cole, Pollard, Steven M, Patel, Anoop, Paddison, Patrick J, Plaisier, Christopher L

“…Single‐cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we…”
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Professional Bereavement Photography in the Setting of Perinatal Loss: A Qualitative Analysis by Ramirez, Faustine D., Bogetz, Jori F., Kufeld, Megan, Yee, Lynn M.

“…Perinatal loss, including fetal and infant death, is a devastating experience for parents, resulting in long-term adverse physical and psychosocial outcomes…”
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Efficient Multi-Allelic Genome Editing of Primary Cell Cultures via CRISPR-Cas9 Ribonucleoprotein Nucleofection by Hoellerbauer, Pia, Kufeld, Megan, Paddison, Patrick J

“…CRISPR-Cas9-based technologies have revolutionized experimental manipulation of mammalian genomes. However, limitations regarding the delivery and efficacy of…”
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GENE-10. A SIMPLE AND EFFICIENT METHOD FOR GENERATING MULTI-ALLELIC INSERTION-DELETION MUTATIONS AND PRECISE DELETIONS IN PRIMARY HUMAN CELL CULTURES by Hoellerbauer, Pia, Kufeld, Megan, Arora, Sonali, Wu, Hua-Jun, Feldman, Heather, Paddison, Patrick

“…Abstract CRISPR-Cas9-based technologies have revolutionized experimental manipulation of the human genome by enabling generation of site-specific genetic…”
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COMP-04. MODELING PRECISION ONCOLOGY FOR GLIOBLASTOMA THROUGH INTEGRATION OF DESCRIPTIVE, FUNCTIONAL, AND NETWORK-BASED GENOMICS by Hoellerbauer, Pia, Kufeld, Megan, Arora, Sonali, Girard, Emily, Olson, James, Biery, Matthew, Chambwe, Nyasha, Paddison, Patrick

“…Abstract Precision oncology is largely based on the notion that identification and targeting of oncogenic drivers will lead to improved clinical outcomes…”
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Abstract 413: Emerging principles in synthetic lethality in glioblastoma by Hoellerbauer, Pia, Arora, Sonali, Kufeld, Megan, Carter, Lucas, Girard, Emily J., Feldman, Heather, Corrin, Philip, Olson, James M., Paddison, Patrick J.

“…Abstract Synthetic lethality occurs when mutations in two otherwise nonessential genes are combined to cause lethality. Because cancer is a disease of genetic…”
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A simple and highly efficient method for multi‐allelic CRISPR‐Cas9 editing in primary cell cultures by Hoellerbauer, Pia, Kufeld, Megan, Arora, Sonali, Wu, Hua‐Jun, Feldman, Heather M., Paddison, Patrick J.

“…Background CRISPR‐Cas9‐based technologies have revolutionized experimental manipulation of mammalian genomes. None‐the‐less, limitations of the delivery and…”
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FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation and lethality in glioblastoma and other cancers by Hoellerbauer, Pia, Kufeld, Megan, Arora, Sonali, Mitchell, Kelly, Girard, Emily J, Herman, Jacob A, Olson, James M, Paddison, Patrick J

“…Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. To identify genes differentially required for the viability of GBM stem-like cells…”
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