Search Results - "Kuentzel, Katharina B."

Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase by Bradić, Ivan, Liesinger, Laura, Kuentzel, Katharina B., Vujić, Nemanja, Trauner, Michael, Birner-Gruenberger, Ruth, Kratky, Dagmar

“…Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL…”
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Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice by Kuentzel, Katharina B, Bradić, Ivan, Mihalič, Zala N, Korbelius, Melanie, Rainer, Silvia, Pirchheim, Anita, Kargl, Julia, Kratky, Dagmar

“…Advanced maternal age and obesity are the main risk factors to develop gestational diabetes mellitus (GDM). Obesity is a consequence of the increased storage…”
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Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth by Kuentzel, Katharina B, Bradić, Ivan, Akhmetshina, Alena, Korbelius, Melanie, Rainer, Silvia, Kolb, Dagmar, Gauster, Martin, Vujić, Nemanja, Kratky, Dagmar

“…Cholesterol and fatty acids are essential lipids that are critical for membrane biosynthesis and fetal organ development. Cholesteryl esters (CE) are degraded…”
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Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice by Goeritzer, Madeleine, Kuentzel, Katharina B, Beck, Sarah, Korbelius, Melanie, Rainer, Silvia, Bradić, Ivan, Kolb, Dagmar, Mussbacher, Marion, Schrottmaier, Waltraud C, Assinger, Alice, Schlagenhauf, Axel, Rost, René, Gottschalk, Benjamin, Eichmann, Thomas O, Züllig, Thomas, Graier, Wolfgang F, Vujić, Nemanja, Kratky, Dagmar

“…Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades…”
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Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases by Bradić, Ivan, Kuentzel, Katharina B., Honeder, Sophie, Grabner, Gernot F., Vujić, Nemanja, Zimmermann, Robert, Birner-Gruenberger, Ruth, Kratky, Dagmar

“…Lysosomal acid lipase (LAL) is the key enzyme, which degrades neutral lipids at an acidic pH in lysosomes. The role of LAL in various cellular processes has…”
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Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration by Bianco, Valentina, Korbelius, Melanie, Vujic, Nemanja, Akhmetshina, Alena, Amor, Melina, Kolb, Dagmar, Pirchheim, Anita, Bradic, Ivan, Kuentzel, Katharina B., Buerger, Martin, Schauer, Silvia, Phan, Huyen T.T., Bulfon, Dominik, Hoefler, Gerald, Zimmermann, Robert, Kratky, Dagmar

“…To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid…”
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Global analysis of protein arginine methylation by Zhang, Fangrong, Kerbl-Knapp, Jakob, Rodriguez Colman, Maria J., Meinitzer, Andreas, Macher, Therese, Vujić, Nemanja, Fasching, Sandra, Jany-Luig, Evelyne, Korbelius, Melanie, Kuentzel, Katharina B., Mack, Maximilian, Akhmetshina, Alena, Pirchheim, Anita, Paar, Margret, Rinner, Beate, Hörl, Gerd, Steyrer, Ernst, Stelzl, Ulrich, Burgering, Boudewijn, Eisenberg, Tobias, Pertschy, Brigitte, Kratky, Dagmar, Madl, Tobias

“…Quantitative information about the levels and dynamics of post-translational modifications (PTMs) is critical for an understanding of cellular functions…”
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Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice by Akhmetshina, Alena, Bianco, Valentina, Bradić, Ivan, Korbelius, Melanie, Pirchheim, Anita, Kuentzel, Katharina B, Eichmann, Thomas O, Hinteregger, Helga, Kolb, Dagmar, Habisch, Hansjoerg, Liesinger, Laura, Madl, Tobias, Sattler, Wolfgang, Radović, Branislav, Sedej, Simon, Birner-Gruenberger, Ruth, Vujić, Nemanja, Kratky, Dagmar

“…Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite the…”
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Lanifibranor Reduces Inflammation and Improves Dyslipidemia in Lysosomal Acid Lipase-Deficient Mice by Bradić, Ivan, Vujić, Nemanja, Kuentzel, Katharina B., Habisch, Hansjörg, Pirchheim, Anita, Akhmetshina, Alena, Henderson, John D., Madl, Tobias, Deshmukh, Atul S., Kratky, Dagmar

“…Recent studies showed that patients suffering from lysosomal acid lipase deficiency (LAL-D) benefit from enzyme replacement therapy; however, liver…”
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Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo by Goeritzer, Madeleine, Schlager, Stefanie, Kuentzel, Katharina B, Vujić, Nemanja, Korbelius, Melanie, Rainer, Silvia, Kolb, Dagmar, Mussbacher, Marion, Salzmann, Manuel, Schrottmaier, Waltraud C, Assinger, Alice, Schlagenhauf, Axel, Madreiter-Sokolowski, Corina T, Blass, Sandra, Eichmann, Thomas O, Graier, Wolfgang F, Kratky, Dagmar

“…According to genome-wide RNA sequencing data from human and mouse platelets, adipose triglyceride lipase (ATGL), the main lipase catalyzing triglyceride (TG)…”
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Recent insights into lysosomal acid lipase deficiency by Korbelius, Melanie, Kuentzel, Katharina B., Bradić, Ivan, Vujić, Nemanja, Kratky, Dagmar

“…Mutations in the LIPA gene cause LAL deficiency (LAL-D), a rare autosomal-recessive multiorgan condition with fatal outcome if residual lysosomal acid lipase…”
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From LAL-D to MASLD: Insights into the role of LAL and Kupffer cells in liver inflammation and lipid metabolism by Bradić, Ivan, Kuentzel, Katharina B., Pirchheim, Anita, Rainer, Silvia, Schwarz, Birgit, Trauner, Michael, Larsen, Martin R., Vujić, Nemanja, Kratky, Dagmar

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver pathology worldwide, closely associated with obesity and metabolic…”
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ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages by Vujić, Nemanja, Bradić, Ivan, Goeritzer, Madeleine, Kuentzel, Katharina B, Rainer, Silvia, Kratky, Dagmar, Radović, Branislav

“…Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that,…”
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Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis by Korbelius, Melanie, Vujić, Nemanja, Kuentzel, Katharina B., Obrowsky, Sascha, Rainer, Silvia, Haemmerle, Guenter, Rülicke, Thomas, Kratky, Dagmar

“…Enterocytes of the small intestine (SI) play an important role in maintaining systemic lipid levels by regulating dietary lipid absorption and postprandial…”
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How does the loss of intracellular lipases affect mouse placenta and fetus? by Kuentzel, Katharina B., Korbelius, Melanie, Bradić, Ivan, Vujić, Nemanja, Gauster, Martin, Wadsack, Christian, Kratky, Dagmar

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Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice by von Voss, Liv, Arora, Tulika, Assis, Juliana, Kuentzel, Katharina B, Arfelt, Kristine N, Nøhr, Mark K, Grevengoed, Trisha J, Arumugam, Manimozhiyan, Mandrup-Poulsen, Thomas, Rosenkilde, Mette M

“…Abstract Context Excessive eating and intake of a Western diet negatively affect the intestinal immune system, resulting in compromised glucose homeostasis and…”
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ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages by Vujić, Nemanja, Bradić, Ivan, Goeritzer, Madeleine, Kuentzel, Katharina B., Rainer, Silvia, Kratky, Dagmar, Radović, Branislav

“…Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that,…”
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