Search Results - "Kuemmerle, Jared"

Discovery and Structure−Activity Relationship of 3-Aryl-5-aryl-1,2,4-oxadiazoles as a New Series of Apoptosis Inducers and Potential Anticancer Agents by Zhang, Han-Zhong, Kasibhatla, Shailaja, Kuemmerle, Jared, Kemnitzer, William, Ollis-Mason, Kristin, Qiu, Ling, Crogan-Grundy, Candace, Tseng, Ben, Drewe, John, Cai, Sui Xiong

“…We have identified 5-(3-chlorothiophen-2-yl)-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazole (1d) as a novel apoptosis inducer through our caspase- and cell-based…”
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Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell-and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1-and 3-positions by KEMNITZER, William, KUEMMERLE, Jared, SONGCHUN JIANG, ZHANG, Han-Zhong, SIRISOMA, Nilantha, KASIBHATLA, Shailaja, CROGAN-GRUNDY, Candace, TSENG, Ben, DREWE, John, SUI XIONG CAI

“…1-Benzoyl-3-cyanopyrrolo[1,2-a]quinoline (2a) was identified as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay…”
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The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach by Jessen, Katayoun A, English, Nicole M, Yu Wang, Jean, Maliartchouk, Sergei, Archer, Shannon P, Qiu, Ling, Brand, Regina, Kuemmerle, Jared, Zhang, Han-Zhong, Gehlsen, Kurt, Drewe, John, Tseng, Ben, Cai, Sui Xiong, Kasibhatla, Shailaja

“…A novel series of 3,5-diaryl-oxadiazoles was identified as apoptosis-inducing agents through our cell and chemical genetics–based screening assay for compounds…”
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Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents by Kemnitzer, William, Kuemmerle, Jared, Zhang, Han-Zhong, Kasibhatla, Shailaja, Tseng, Ben, Drewe, John, Cai, Sui Xiong

“…SAR studies of 3-aryl-5-aryl-1,2,4-oxadiazoles and the identification of 4g and 4h as lead compounds are reported. As a continuation of our efforts to discover…”
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Discovery of 1-benzoyl-3-cyanopyrrolo[1,2- a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure–activity relationships of the 4-, 5-, 6-, 7- and 8-positions by Kemnitzer, William, Kuemmerle, Jared, Jiang, Songchun, Sirisoma, Nilantha, Kasibhatla, Shailaja, Crogan-Grundy, Candace, Tseng, Ben, Drewe, John, Cai, Sui Xiong

“…The synthesis and SAR studies of the 4-, 5-, 6-, 7- and 8-positions of apoptosis inducing 1-benzoyl-3-cyanopyrrolo[1,2- a]quinolines are reported. As a…”
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Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6 H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid by Kuemmerle, Jared, Jiang, Songchun, Tseng, Ben, Kasibhatla, Shailaja, Drewe, John, Cai, Sui Xiong

“…We have reported the discovery of gambogic acid (GA) as a potent apoptosis inducer and the identification of transferrin receptor as its molecular target. In…”
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