Search Results - "Kueider‐Paisley, Alexandra"

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome by Arnold, Matthias, Nho, Kwangsik, Kueider-Paisley, Alexandra, Massaro, Tyler, Huynh, Kevin, Brauner, Barbara, MahmoudianDehkordi, Siamak, Louie, Gregory, Moseley, M. Arthur, Thompson, J. Will, John-Williams, Lisa St, Tenenbaum, Jessica D., Blach, Colette, Chang, Rui, Brinton, Roberta D., Baillie, Rebecca, Han, Xianlin, Trojanowski, John Q., Shaw, Leslie M., Martins, Ralph, Weiner, Michael W., Trushina, Eugenia, Toledo, Jon B., Meikle, Peter J., Bennett, David A., Krumsiek, Jan, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Kastenmüller, Gabi

“…Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors…”
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Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers by Nho, Kwangsik, Kueider-Paisley, Alexandra, MahmoudianDehkordi, Siamak, Arnold, Matthias, Risacher, Shannon L., Louie, Gregory, Blach, Colette, Baillie, Rebecca, Han, Xianlin, Kastenmüller, Gabi, Jia, Wei, Xie, Guoxiang, Ahmad, Shahzad, Hankemeier, Thomas, van Duijn, Cornelia M., Trojanowski, John Q., Shaw, Leslie M., Weiner, Michael W., Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima

“…Bile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests gut microbiota…”
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Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex‐Dependent Manner by Chen, Tianlu, Wang, Lu, Xie, Guoxiang, Kristal, Bruce S., Zheng, Xiaojiao, Sun, Tao, Arnold, Matthias, Louie, Gregory, Li, Mengci, Wu, Lirong, Mahmoudiandehkordi, Siamak, Sniatynski, Matthew J., Borkowski, Kamil, Guo, Qihao, Kuang, Junliang, Wang, Jieyi, Nho, Kwangsik, Ren, Zhenxing, Kueider‐Paisley, Alexandra, Blach, Colette, Kaddurah‐Daouk, Rima, Jia, Wei

“…Sex disparities in serum bile acid (BA) levels and Alzheimer's disease (AD) prevalence have been established. However, the precise link between changes in…”
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Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome by MahmoudianDehkordi, Siamak, Arnold, Matthias, Nho, Kwangsik, Ahmad, Shahzad, Jia, Wei, Xie, Guoxiang, Louie, Gregory, Kueider-Paisley, Alexandra, Moseley, M. Arthur, Thompson, J. Will, St John Williams, Lisa, Tenenbaum, Jessica D., Blach, Colette, Baillie, Rebecca, Han, Xianlin, Bhattacharyya, Sudeepa, Toledo, Jon B., Schafferer, Simon, Klein, Sebastian, Koal, Therese, Risacher, Shannon L., Kling, Mitchel Allan, Motsinger-Reif, Alison, Rotroff, Daniel M., Jack, John, Hankemeier, Thomas, Bennett, David A., De Jager, Philip L., Trojanowski, John Q., Shaw, Leslie M., Weiner, Michael W., Doraiswamy, P. Murali, van Duijn, Cornelia M., Saykin, Andrew J., Kastenmüller, Gabi, Kaddurah-Daouk, Rima

“…Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut-brain axis in neurodegeneration…”
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Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways by Zhao, Na, Ren, Yingxue, Yamazaki, Yu, Qiao, Wenhui, Li, Fuyao, Felton, Lindsey M., Mahmoudiandehkordi, Siamak, Kueider-Paisley, Alexandra, Sonoustoun, Berkiye, Arnold, Matthias, Shue, Francis, Zheng, Jiaying, Attrebi, Olivia N., Martens, Yuka A., Li, Zonghua, Bastea, Ligia, Meneses, Axel D., Chen, Kai, Thompson, J. Will, St John-Williams, Lisa, Tachibana, Masaya, Aikawa, Tomonori, Oue, Hiroshi, Job, Lucy, Yamazaki, Akari, Liu, Chia-Chen, Storz, Peter, Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Kaddurah-Daouk, Rima, Bu, Guojun

“…Evidence suggests interplay among the three major risk factors for Alzheimer’s disease (AD): age, APOE genotype, and sex. Here, we present comprehensive…”
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Comparison of Approaches for Equating Different Versions of the Mini-Mental State Examination Administered in 22 Studies by Gross, Alden L, Kueider-Paisley, Alexandra M, Sullivan, Campbell, Schretlen, David

“…Abstract The Mini-Mental State Examination (MMSE) is one of the most widely used cognitive screening tests in the world. However, its administration and…”
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Predictive metabolic networks reveal sex‐ and APOE genotype‐specific metabolic signatures and drivers for precision medicine in Alzheimer's disease by Chang, Rui, Trushina, Eugenia, Zhu, Kuixi, Zaidi, Syed Shujaat Ali, Lau, Branden M., Kueider‐Paisley, Alexandra, Moein, Sara, He, Qianying, Alamprese, Melissa L., Vagnerova, Barbora, Tang, Andrew, Vijayan, Ramachandran, Liu, Yanyun, Saykin, Andrew J., Brinton, Roberta D., Kaddurah‐Daouk, Rima

“…Introduction Late‐onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic…”
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Peripheral serum metabolomic profiles inform central cognitive impairment by Wang, Jingye, Wei, Runmin, Xie, Guoxiang, Arnold, Matthias, Kueider-Paisley, Alexandra, Louie, Gregory, Mahmoudian Dehkordi, Siamak, Blach, Colette, Baillie, Rebecca, Han, Xianlin, De Jager, Philip L., Bennett, David A., Kaddurah-Daouk, Rima, Jia, Wei

“…The incidence of Alzheimer's disease (AD) increases with age and is becoming a significant cause of worldwide morbidity and mortality. However, the metabolic…”
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Investigating the importance of acylcarnitines in Alzheimer’s disease by Baloni, Priyanka, Nho, Kwangsik, Arnold, Matthias, Louie, Gregory, Kueider‐Paisley, Alexandra, Saykin, Andrew J., Ekroos, Kim, Funk, Cory, Hood, Leroy, Price, Nathan D, Baillie, Rebecca, Kastenmüller, Gabi, Han, Xianlin, Kaddurah‐Daouk, Rima F.

“…Background L‐carnitine is present in the mammalian cells as free carnitine (FC) and acylcarnitine and the adult human brain contains almost 10% of long chain…”
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Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau by Kling, Mitchel A., Goodenowe, Dayan B., Senanayake, Vijitha, MahmoudianDehkordi, Siamak, Arnold, Matthias, Massaro, Tyler J., Baillie, Rebecca, Han, Xianlin, Leung, Yuk‐Yee, Saykin, Andrew J., Nho, Kwangsik, Kueider‐Paisley, Alexandra, Tenenbaum, Jessica D., Wang, Li‐San, Shaw, Leslie M., Trojanowski, John Q., Kaddurah‐Daouk, Rima F.

“…Introduction Altered lipid metabolism is implicated in Alzheimer's disease (AD), but the mechanisms remain obscure. Aging‐related declines in circulating…”
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Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease by Baloni, Priyanka, Arnold, Matthias, Buitrago, Luna, Nho, Kwangsik, Moreno, Herman, Huynh, Kevin, Brauner, Barbara, Louie, Gregory, Kueider-Paisley, Alexandra, Suhre, Karsten, Saykin, Andrew J., Ekroos, Kim, Meikle, Peter J., Hood, Leroy, Price, Nathan D., Doraiswamy, P. Murali, Funk, Cory C., Hernández, A. Iván, Kastenmüller, Gabi, Baillie, Rebecca, Han, Xianlin, Kaddurah-Daouk, Rima

“…Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer’s disease. Genome-wide and transcriptome-wide association studies have…”
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ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease by Ko, Yi-An, Billheimer, Jeffrey T, Lyssenko, Nicholas N, Kueider-Paisley, Alexandra, Wolk, David A, Arnold, Steven E, Leung, Yuk Yee, Shaw, Leslie M, Trojanowski, John Q, Kaddurah-Daouk, Rima F, Kling, Mitchel A, Rader, Daniel J

“…Alzheimer's disease (AD) shares risk factors with cardiovascular disease (CVD) and dysregulated cholesterol metabolism is a mechanism common to both diseases…”
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Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers by Nho, Kwangsik, Kueider-Paisley, Alexandra, Ahmad, Shahzad, MahmoudianDehkordi, Siamak, Arnold, Matthias, Risacher, Shannon L, Louie, Gregory, Blach, Colette, Baillie, Rebecca, Han, Xianlin, Kastenmüller, Gabi, Trojanowski, John Q, Shaw, Leslie M, Weiner, Michael W, Doraiswamy, P Murali, van Duijn, Cornelia, Saykin, Andrew J, Kaddurah-Daouk, Rima

“…Increasing evidence suggests an important role of liver function in the pathophysiology of Alzheimer disease (AD). The liver is a major metabolic hub;…”
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Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease by Baloni, Priyanka, Funk, Cory C., Yan, Jingwen, Yurkovich, James T., Kueider-Paisley, Alexandra, Nho, Kwangsik, Heinken, Almut, Jia, Wei, Mahmoudiandehkordi, Siamak, Louie, Gregory, Saykin, Andrew J., Arnold, Matthias, Kastenmüller, Gabi, Griffiths, William J., Thiele, Ines, Kaddurah-Daouk, Rima, Kueider-Paisley, Alexandra, Louie, Gregory, Doraiswamy, P. Murali, Blach, Colette, Moseley, Arthur, Thompson, J. Will, Mahmoudiandehkhordi, Siamak, Welsh-Balmer, Kathleen, Plassman, Brenda, Saykin, Andrew, Nho, Kwangsik, Kastenmüller, Gabi, Arnold, Matthias, Bhattacharyya, Sudeepa, Han, Xianlin, Baillie, Rebecca, Fiehn, Oliver, Barupal, Dinesh, Meikle, Peter, Mazmanian, Sarkis, Kling, Mitchel, Shaw, Leslie, Trojanowski, John, Toledo, Jon, van Duijin, Cornelia, Hankemier, Thomas, Thiele, Ines, Heinken, Almut, Price, Nathan, Funk, Cory, Baloni, Priyanka, Jia, Wei, Wishart, David, Brinton, Roberta, Chang, Rui, Farrer, Lindsay, Au, Rhoda, Qiu, Wendy, Würtz, Peter, Mangravite, Lara, Krumsiek, Jan, Newman, John, Zhang, Bin, Moreno, Herman, Kaddurah-Daouk, Rima, Price, Nathan D.

“…Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol…”
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Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease by Liang, Nuanyi, Nho, Kwangsik, Newman, John W., Arnold, Matthias, Huynh, Kevin, Meikle, Peter J., Borkowski, Kamil, Kaddurah-Daouk, Rima

“…Inflammation is an important factor in Alzheimer’s disease (AD). An NMR measurement in plasma, glycoprotein acetyls (GlycA), captures the overall level of…”
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A blood-based signature of cerebrospinal fluid Aβ 1-42 status by Goudey, Benjamin, Fung, Bowen J, Schieber, Christine, Faux, Noel G

“…It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical…”
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Serum metabolome informs neuroimaging biomarkers for Alzheimer’s disease by Nho, Kwangsik, Kueider‐Paisley, Alexandra, Arnold, Matthias, Dehkordi, Siamak Mahmoudian, Risacher, Shannon L., Louie, Gregory, Blach, Colette, Baillie, Rebecca, Han, Xianlin, Kastenmüller, Gabi, Doraiswamy, P. Murali, Kaddurah‐Daouk, Rima F., Saykin, Andrew J.

“…Background Accumulating evidence suggests that Alzheimer’s disease (AD) patients display metabolic dysfunction. Metabolomics is a powerful tool for studying…”
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Serum metabolome informs neuroimaging biomarkers for Alzheimer’s disease: Genome‐metabolome‐phenome: Towards an integrated molecular atlas for Alzheimer's disease by Nho, Kwangsik, Kueider‐Paisley, Alexandra, Arnold, Matthias, Dehkordi, Siamak Mahmoudian, Risacher, Shannon L., Louie, Gregory, Blach, Colette, Baillie, Rebecca, Han, Xianlin, Kastenmüller, Gabi, Doraiswamy, P. Murali, Kaddurah‐Daouk, Rima F., Saykin, Andrew J.

“…Abstract Background Accumulating evidence suggests that Alzheimer’s disease (AD) patients display metabolic dysfunction. Metabolomics is a powerful tool for…”
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Transcriptomics, metabolomics, lipidomics, metabolic flux and mGWAS analyses of sphingolipid pathway highlights novel drugs for Alzheimer’s disease by Baloni, Priyanka, Arnold, Matthias, Moreno, Herman, Nho, Kwangsik, Kastenmüller, Gabi, Suhre, Karsten, Buitrago, Luna, Louie, Gregory, Kueider‐Paisley, Alexandra, Saykin, Andrew J., Ekroos, Kim, Meikle, Peter J., Huynh, Kevin, Funk, Cory C., Hood, Leroy, Price, Nathan D., Baillie, Rebecca, Han, Xianlin, Kaddurah‐Daouk, Rima F.

“…Background Alzheimer’s disease (AD) related neurodegeneration has been correlated with metabolic dysfunction. Sphingomyelins (SM), a class of lipids found in…”
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SERUM INDICES OF ETHANOLAMINE PLASMALOGENS AND PHOSPHATIDE METABOLISM IN THE COMBINED ADNI-1/GO/2 COHORT: DOES THE LIVER CONTRIBUTE TO AD RISK BY FAILING TO SUPPLY KEY LIPIDS TO THE BRAIN? by Kling, Mitchel A., Goodenowe, Dayan B., Senanayake, Vijitha, MahmoudianDehkordi, Siamak, Baillie, Rebecca, Han, Xianlin, Kueider-Paisley, Alexandra, Kaddurah-Daouk, Rima F.

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