Search Results - "Kuehner, Jason"

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  1. 1

    Unravelling the means to an end: RNA polymerase II transcription termination by Moore, Claire, Kuehner, Jason N, Pearson, Erika L

    Published in Nature reviews. Molecular cell biology (01-05-2011)
    “…Key Points RNA polymerase II (Pol II) transcribes all eukaryotic protein-coding genes and most non-coding RNA genes. The final step of transcription is…”
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    Journal Article
  2. 2

    Regulation of a Eukaryotic Gene by GTP-Dependent Start Site Selection and Transcription Attenuation by Kuehner, Jason N., Brow, David A.

    Published in Molecular cell (25-07-2008)
    “…Guanine nucleotide negatively regulates yeast inosine monophosphate dehydrogenase (IMPDH) mRNA synthesis by an unknown mechanism. IMPDH catalyzes the first…”
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    Journal Article
  3. 3
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    Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3′-end processing factors is a conserved DNA damage response in eukaryotes by Kuehner, Jason N., Kaufman, James W., Moore, Claire

    Published in DNA repair (01-09-2017)
    “…[Display omitted] •Yeast mRNA 3′-end processing factors CFIA and CPF promote tolerance to UV damage.•CFIA/CPF contribution to DNA integrity is not limited to…”
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    Journal Article
  5. 5

    Genome-Wide Distribution of Yeast RNA Polymerase II and Its Control by Sen1 Helicase by Steinmetz, Eric J., Warren, Christopher L., Kuehner, Jason N., Panbehi, Bahman, Ansari, Aseem Z., Brow, David A.

    Published in Molecular cell (08-12-2006)
    “…Functional engagement of RNA polymerase II (Pol II) with eukaryotic chromosomes is a fundamental and highly regulated biological process. Here we present a…”
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    Journal Article
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    RNA polymerase II transcription attenuation at the yeast DNA repair gene DEF1 is biologically significant and dependent on the Hrp1 RNA-recognition motif by Amodeo, Maria E, Mitchell, Shane P C, Pavan, Vincent, Kuehner, Jason N

    Published in G3 : genes - genomes - genetics (12-01-2023)
    “…Abstract Premature transcription termination (i.e. attenuation) is a potent gene regulatory mechanism that represses mRNA synthesis. Attenuation of RNA…”
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    Journal Article
  8. 8

    DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast by Graber, Joel H, Nazeer, Fathima I, Yeh, Pei-chun, Kuehner, Jason N, Borikar, Sneha, Hoskinson, Derick, Moore, Claire L

    Published in Genome research (01-10-2013)
    “…Systemic response to DNA damage and other stresses is a complex process that includes changes in the regulation and activity of nearly all stages of gene…”
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    Journal Article
  9. 9

    Quantitative Analysis of in Vivo Initiator Selection by Yeast RNA Polymerase II Supports a Scanning Model by Kuehner, Jason N., Brow, David A.

    Published in The Journal of biological chemistry (19-05-2006)
    “…Initiation of transcription by RNA polymerase II (RNAP II) on Saccharomyces cerevisiae messenger RNA (mRNA) genes typically occurs at multiple sites 40–120 bp…”
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    Journal Article
  10. 10

    RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1 , Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination by Whalen, Courtney, Tuohy, Christine, Tallo, Thomas, Kaufman, James W, Moore, Claire, Kuehner, Jason N

    Published in G3 : genes - genomes - genetics (01-06-2018)
    “…Termination of RNA Polymerase II (Pol II) activity serves a vital cellular role by separating ubiquitous transcription units and influencing RNA fate and…”
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    Journal Article
  11. 11

    Reconstitution of CF IA from Overexpressed Subunits Reveals Stoichiometry and Provides Insights into Molecular Topology by Gordon, James M. B, Shikov, Sergei, Kuehner, Jason N, Liriano, Melissa, Lee, Eunhee, Stafford, Walter, Poulsen, Mathias Bach, Harrison, Celia, Moore, Claire, Bohm, Andrew

    Published in Biochemistry (Easton) (29-11-2011)
    “…Yeast cleavage factor I (CF I) is an essential complex of five proteins that binds signal sequences at the 3′ end of yeast mRNA. CF I is required for correct…”
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    Journal Article
  12. 12

    Money, Sex, and Drugs: A Case Study to Teach the Genetics of Antibiotic Resistance by Cloud-Hansen, Karen A, Kuehner, Jason N, Tong, Lillian, Miller, Sarah, Handelsman, Jo

    Published in CBE life sciences education (01-01-2008)
    “…The goal of the work reported here was to help students expand their understanding of antibiotic resistance, the Central Dogma, and evolution. We developed a…”
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    Journal Article
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    A simple, robust, broadly applicable insertion mutagenesis method to create random fluorescent protein: target protein fusions by Pike, Andrew, Pietryski, Cassandra, Deighan, Padraig, Kuehner, Jason, Lau, Derek, Seshan, Anupama, March, Paul E

    Published in G3 : genes - genomes - genetics (07-05-2024)
    “…A simple, broadly applicable method was developed using an in vitro transposition reaction followed by transformation into Escherichia coli and screening…”
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    Journal Article
  15. 15

    Mechanism and regulation of yeast RNA polymerase II transcription initiation and termination by Kuehner, Jason Nicholas

    Published 01-01-2008
    “…RNA Polymerase II (Pol II) transcribes most eukaryotic genes and is subject to extensive regulatory control. Initiation of Pol II transcription in the yeast…”
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    Dissertation