Search Results - "Kuehne, M E"

18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats by Glick, S.D., Kuehne, M.E., Maisonneuve, I.M., Bandarage, U.K., Molinari, H.H.

“…Ibogaine, a naturally occurring iboga alkaloid, has been claimed to be effective in treating addiction to opioids and stimulants, and has been reported to…”
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Acute iboga alkaloid effects on extracellular serotonin (5-HT) levels in nucleus accumbens and striatum in rats by Wei, D., Maisonneuve, I.M., Kuehne, M.E., Glick, S.D.

“…The iboga alkaloid, ibogaine, its metabolite, noribogaine, and the congener, 18-methoxycoronaridine (18-MC) have all been claimed to have anti-addictive…”
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18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats by GLICK, S. D, MAISONNEUVE, I. M, VISKER, K. E, FRITZ, K. A, BANDARAGE, U. K, KUEHNE, M. E

“…Two studies were conducted to assess, in vivo, potential anti-nicotinic effects of the iboga alkaloid ibogaine and its synthetic congener…”
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Syntheses of 5a‘-homo-Vinblastine and Congeners Designed to Establish Structural Determinants for Isolation of Atropisomers by KUEHNE, Martin E., COWEN, Scott D., XU, Feng, BORMAN, Linda S.

“…The syntheses of 5a'-homo-vinblastine (3a) and its C-20' methyl congener 62a were achieved. In contrast to vinblastine, these compounds did not allow isolation…”
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Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum by Glick, S D, Kuehne, M E, Raucci, J, Wilson, T E, Larson, D, Keller, Jr, R W, Carlson, J N

“…Ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addiction to opioid and stimulant drugs and has been reported to…”
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Attenuation of Alcohol Consumption by a Novel Nontoxic Ibogaine Analogue (18-Methoxycoronaridine) in Alcohol-Preferring Rats by Rezvani, Amir H, Overstreet, David H, Yang, Ying, Maisonneuve, Isabelle M, Bandarage, Upul K, Kuehne, Martin E, Glick, Stanley D

“…We previously reported that single administration of ibogaine, an indol alkaloid with antiaddictive properties, dose dependently reduced alcohol intake in…”
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New Ferrocenyl Chiral Auxiliary Substituents for Amines. Applications to Syntheses of Mossambine and Vinblastine by Kuehne, Martin E., Dai, Wenning, Li, Yun-Long

“…(+)−(R)-1,2-(α-(R)-Mesyloxy-β-dimethyltetramethylene)-ferrocene was synthesized and used as a chiral auxiliary for N-alkylation of methyl…”
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The Syntheses of 16a‘-homo-Leurosidine and 16a‘-homo-Vinblastine. Generation of Atropisomers by Kuehne, Martin E, Qin, Yong, Huot, Anne E, Bane, Susan L

“…The synthesis of 16a‘-homo-leurosidine was achieved through enantioselective generation of a ring D‘-seco-precursor 33 (without requirement of a chiral…”
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Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies by Deecher, D C, Teitler, M, Soderlund, D M, Bornmann, W G, Kuehne, M E, Glick, S D

“…Assays using radioligands were used to assess the actions of ibogaine and harmaline on various receptor types. Ibogaine congeners showed affinity for opiate…”
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Structurally modified ibogaine analogs exhibit differing affinities for NMDA receptors by Layer, Richard T., Skolnick, Phil, Bertha, Craig M., Bandarage, Upul K., Kuehne, Martin E., Popik, Piotr

“…Based on both preclinical findings and anecdotal evidence in man, the psychoactive indole alkaloid ibogaine has been suggested to have anti-addictive…”
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Time-dependent interactions between iboga agents and cocaine by MAISONNEUVE, I. M, VISKER, K. E, MANN, G. L, BANDARAGE, U. K, KUEHNE, M. E, GLICK, S. D

“…The purpose of this study was to clarify the effects of iboga agents on cocaine-induced hyperactivity. Both inhibition and enhancement of cocaine-induced…”
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Total syntheses of strychnos alkaloids by Kuehne, M. E., Brook, C. S., Xu, F., Parsons, R.

“…Abstract…”
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Single site-modified congeners of vinblastine dissociate its various anti-microtubule actions by Borman, L S, Kuehne, M E, Matson, P A, Marko, I, Zebovitz, T C

“…New C-20' alkyl congeners of vinblastine (VBL) were examined for their reaction with purified microtubule protein or steady-state microtubules in vitro. We…”
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Specific alterations in the biological activities of C-20'-modified vinblastine congeners by Borman, L S, Kuehne, M E

“…Both the anti-tumor and toxic activities of the vinca alkaloid dimers, vinblastine (VBL) and vincristine (VCR), may reside at the level of their known cellular…”
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Modulation of drug cytotoxicity in wild-type and multidrug-resistant tumor cells by by stereoisomeric series of C-20'-vinblastine congeners that lack antimicrotubule activity by BORMAN, L. S, BORNMANN, W. G, KUEHNE, M. E

“…Seven binary vinca alkaloid congeners were newly synthesized as the C14' or C16'(20') or C14'16'(20') stereoisomers of C20'-modified VBL. These congeners…”
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Biomimetic syntheses of indole alkaloids. 11. Syntheses of .beta.-carboline and indoloazepine intermediates by Kuehne, M. E, Bohnert, J. C, Bornmann, W. G, Kirkemo, C. L, Kuehne, S. E, Seaton, P. J, Zebovitz, T. C

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Reduction of amides and lactams to amines by reactions with phosphorus oxychloride and sodium borohydride by Kuehne, M. E, Shannon, P. J

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Thiyl radical- and mercuric ion-induced cyclizations of dimethyl dipropargylmalonate and dimethyl propargyl-3-thiylallylmalonates by Kuehne, M. E, Parsons, W. H

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Thiyl radical induced cyclizations of dienes. Cyclization of .alpha.-acoradiene, .alpha.-bulnesene, and geranyl acetate to cedrane, patchulane, and cyclogeranyl acetate products by Kuehne, M. E, Damon, R. E

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A Biomimetic Synthesis of the Pauciflorine A and B Skeleton by Kuehne, Martin E, Li, Yun-Long

“…Racemic minovincine (3), following cyclization, reduction, O-tosylation, fragmentation, and carbamate formation, provided the deoxypauciflorine 12…”
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