Search Results - "Kuehl, M."

International Myeloma Working Group molecular classification of multiple myeloma: spotlight review by Fonseca, R, Bergsagel, P L, Drach, J, Shaughnessy, J, Gutierrez, N, Stewart, A K, Morgan, G, Van Ness, B, Chesi, M, Minvielle, S, Neri, A, Barlogie, B, Kuehl, W M, Liebisch, P, Davies, F, Chen-Kiang, S, Durie, B G M, Carrasco, R, Sezer, Orhan, Reiman, Tony, Pilarski, Linda, Avet-Loiseau, H

“…Myeloma is a malignant proliferation of monoclonal plasma cells. Although morphologically similar, several subtypes of the disease have been identified at the…”
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The Burden Associated with Non-Adherence in European Patients with Depression by Pedersini, R, Kuehl, M

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A gene expression signature distinguishes innate response and resistance to proteasome inhibitors in multiple myeloma by Mitra, A K, Harding, T, Mukherjee, U K, Jang, J S, Li, Y, HongZheng, R, Jen, J, Sonneveld, P, Kumar, S, Kuehl, W M, Rajkumar, V, Van Ness, B

“…Extensive interindividual variation in response to chemotherapy is a major stumbling block in achieving desirable efficacy in the treatment of cancers,…”
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Characterization of MYC Translocations in Multiple Myeloma Cell Lines by Dib, Amel, Gabrea, Ana, Glebov, Oleg K., Bergsagel, P. Leif, Kuehl, W. Michael

“…Translocations involving an MYC gene (c >> N >>L) are very late tumor progression events and provide a paradigm for secondary translocations in multiple…”
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Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor by Rozenblum, Ester, Sotelo-Silveira, Jose R, Kim, Gina Y, Zhu, Jack Y, Lau, Christopher C, McNeil, Nicole, Korolevich, Susana, Liao, Hongling, Cherry, James M, Munroe, David J, Ried, Thomas, Meltzer, Paul S, Kuehl, Walter M, Roschke, Anna V

“…A new ovarian near-diploid cell line, OVDM1, was derived from a highly aneuploid serous ovarian metastatic adenocarcinoma. A metastatic tumor was obtained from…”
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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 by Chesi, Marta, Nardini, Elena, Brents, Leslie A, Schröck, Evelin, Ried, Thomas, Kuehl, W. Michael, Bergsagel, P. Leif

“…Dysregulation of oncogenes by translocation to the IgH locus (14q32) is a seminal event in the pathogenesis of B-cell tumours. In multiple myeloma (MM),…”
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Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons by Wang, Yong, Kuehl-Kovarik, M. Cathleen

“…Abstract The gonadotropin-releasing hormone (GnRH) neuron is the pivotal control center in a tightly regulated reproductive axis. The release of GnRH controls…”
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Mutations in the Gene Encoding KRIT1, a Krev-1/rap1a Binding Protein, Cause Cerebral Cavernous Malformations (CCM1) by Sahoo, Trilochan, Johnson, Eric W., Thomas, James W., Kuehl, Peter M., Jones, Thomas L., Dokken, Charles G., Touchman, Jeffrey W., Gallione, Carol J., Lee-Lin, Shih-Queen, Kosofsky, Barry, Kurth, Janice H., Louis, David N., Mettler, Gabrielle, Morrison, Leslie, Gil-Nagel, Antonio, Rich, Steven S., Zabramski, Joseph M., Boguski, Mark S., Green, EricD, Marchuk, Douglas A.

“…Cerebral cavernous malformations (CCM) are congenital vascular anomalies of the brain that can cause significant neurological disabilities, including…”
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Genetic events in the pathogenesis of multiple myeloma by Chng, W.J., MD, Glebov, O., PhD, Bergsagel, P.L., MD, Kuehl, W.M., MD

“…The genetics of myeloma has been increasingly elucidated in recent years. Recurrent genetic events, and also biologically distinct and clinically relevant…”
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Burden of Disease in Stage IV Non-Small Cell Lung Cancer: Comparing ALK Positive and ALK Negative Mutation Status in Egypt, Russia and the United Arab Emirates by Fisher, M, De Renteria, J, Kuehl, M, Suponcic, S, Dharamshi, K

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Genetic Defects and Clinical Characteristics of Patients with a Form of Oculocutaneous Albinism (Hermansky–Pudlak Syndrome) by Gahl, William A, Brantly, Mark, Kaiser-Kupfer, Muriel I, Iwata, Fumino, Hazelwood, Senator, Shotelersuk, Vorasuk, Duffy, Lynn F, Kuehl, Ernest M, Troendle, James, Bernardini, Isa

“…Hermansky–Pudlak syndrome, an autosomal recessive disorder, consists of oculocutaneous albinism, a storage-pool deficiency, and lysosomal accumulation of…”
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Flufenamic acid modulates multiple currents in gonadotropin-releasing hormone neurons by Wang, Yong, Kuehl-Kovarik, M. Cathleen

“…Abstract Reproduction in mammals is dependent upon the appropriate neurosecretion of gonadotropin-releasing hormone (GnRH), yet the endogenous generation of…”
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Episodic Bursting Activity and Response to Excitatory Amino Acids in Acutely Dissociated Gonadotropin-Releasing Hormone Neurons Genetically Targeted with Green Fluorescent Protein by Kuehl-Kovarik, M. Cathleen, Pouliot, Wendy A, Halterman, Gloriana L, Handa, Robert J, Dudek, F. Edward, Partin, Kathryn M

“…The gonadotropin-releasing hormone (GnRH) system, considered to be the final common pathway for the control of reproduction, has been difficult to study…”
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Instabilotyping : Comprehensive identification of frameshift mutations caused by coding region microsatellite instability by MORI, Yuriko, JING YIN, RASHID, Asma, LEGGETT, Barbara A, YOUNG, Joanne, SIMMS, Lisa, KUEHL, Peter M, LANGENBERG, Patricia, MELTZER, Stephen J, STINE, O. Colin

“…Coding region frameshift mutation caused by microsatellite instability (MSI) is one mechanism contributing to tumorigenesis in cancers with MSI in high…”
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Degree of focal immunoglobulin heavy chain locus deletion as a measure of B-cell tumor purity by Bergsagel, P L, Kuehl, W M

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Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms by Zingone, A, Cultraro, C M, Shin, D-M, Bean, C M, Morse, H C, Janz, S, Kuehl, W M

“…The t(4;14) translocation in multiple myeloma (MM) simultaneously dysregulates two apparent oncogenes: fibroblast growth factor receptor 3 ( FGFR3 ) controlled…”
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OP11: Metabolic and vascular determinants of increased left ventricular torsion in patients with type 2 diabetes mellitus by Kuehl, M, Steeds, R, Townend, J, Tahrani, A, Dubb, K, Hughes, S, Phan, T, Stevens, M.J

“…Objective Left ventricular torsion is increased in uncomplicated type 2 diabetes (T2DM) which may be an early manifestation of cardiomyopathy. Our aim was to…”
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Photobiology of endolithic microorganisms in living coral skeletons: 1. Pigmentation, spectral reflectance and variable chlorophyll fluorescence analysis of endoliths in the massive corals Cyphastrea serailia, Porites lutea and Goniastrea australensis by RALPH, P. J, LARKUM, A. W. D, KIIHL, M

“…We used microscopy, reflectance spectroscopy, pigment analysis, and photosynthesis-irradiance curves measured with variable fluorescence techniques to…”
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Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma by Affer, M, Chesi, M, Chen, W D, Keats, J J, Demchenko, Y N, Tamizhmani, K, Garbitt, V M, Riggs, D L, Brents, L A, Roschke, A V, Van Wier, S, Fonseca, R, Bergsagel, P L, Kuehl, W M

“…MYC locus rearrangements—often complex combinations of translocations, insertions, deletions and inversions—in multiple myeloma (MM) were thought to be a late…”
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Corneal Crystals in Nephropathic Cystinosis: Natural History and Treatment with Cysteamine Eyedrops by Gahl, William A., Kuehl, Ernest M., Iwata, Fumino, Lindblad, Anne, Kaiser-Kupfer, Muriel I.

“…Although renal disease is the most prominent feature of the lysosomal storage disease cystinosis, corneal cystine crystal formation remains a major…”
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