Search Results - "Kueh, Andrew J."

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo by Aubrey, Brandon J., Kelly, Gemma L., Kueh, Andrew J., Brennan, Margs S., O’Connor, Liam, Milla, Liz, Wilcox, Stephen, Tai, Lin, Strasser, Andreas, Herold, Marco J.

“…The CRISPR/Cas9 technology enables the introduction of genomic alterations into almost any organism; however, systems for efficient and inducible gene…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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VDAC2 enables BAX to mediate apoptosis and limit tumor development by Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant

“…Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential…”
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The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal by Yang, Yuqing, Kueh, Andrew J., Grant, Zoe L., Abeysekera, Waruni, Garnham, Alexandra L., Wilcox, Stephen, Hyland, Craig D., Di Rago, Ladina, Metcalf, Don, Alexander, Warren S., Coultas, Leigh, Smyth, Gordon K., Voss, Anne K., Thomas, Tim

“…The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylation (H3K14Ac), and the…”
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HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development by Kueh, Andrew J., Dixon, Mathew P., Voss, Anne K., Thomas, Tim

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Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT by Chopin, Michaël, Lun, Aaron T., Zhan, Yifan, Schreuder, Jaring, Coughlan, Hannah, D’Amico, Angela, Mielke, Lisa A., Almeida, Francisca F., Kueh, Andrew J., Dickins, Ross A., Belz, Gabrielle T., Naik, Shalin H., Lew, Andrew M., Bouillet, Phillipe, Herold, Marco J., Smyth, Gordon K., Corcoran, Lynn M., Nutt, Stephen L.

“…Dendritic cells (DCs) are can be broadly divided into conventional (cDC) and plasmacytoid (pDC) subsets. Despite the importance of this lineage diversity, its…”
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DR5 and caspase-8 are dispensable in ER stress-induced apoptosis by Glab, Jason A, Doerflinger, Marcel, Nedeva, Christina, Jose, Irvin, Mbogo, George W, Paton, James C, Paton, Adrienne W, Kueh, Andrew J, Herold, Marco J, Huang, David CS, Segal, David, Brumatti, Gabriella, Puthalakath, Hamsa

“…The endoplasmic reticulum (ER) stress response constitutes cellular reactions triggered by a wide variety of stimuli that disturb folding of proteins, often…”
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Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation by Klein, Brianna J., Jang, Suk Min, Lachance, Catherine, Mi, Wenyi, Lyu, Jie, Sakuraba, Shun, Krajewski, Krzysztof, Wang, Wesley W., Sidoli, Simone, Liu, Jiuyang, Zhang, Yi, Wang, Xiaolu, Warfield, Becka M., Kueh, Andrew J., Voss, Anne K., Thomas, Tim, Garcia, Benjamin A., Liu, Wenshe R., Strahl, Brian D., Kono, Hidetoshi, Li, Wei, Shi, Xiaobing, Côté, Jacques, Kutateladze, Tatiana G.

“…Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our…”
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Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance by Deng, Yexuan, Diepstraten, Sarah T., Potts, Margaret A., Giner, Göknur, Trezise, Stephanie, Ng, Ashley P., Healey, Gerry, Kane, Serena R., Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J., Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S., Visvader, Jane E., Nutt, Stephen L., Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L., Herold, Marco J.

“…CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been exploited in this context. We establish a…”
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Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis by Potts, Margaret A., Mizutani, Shinsuke, Garnham, Alexandra L., Li Wai Suen, Connie S. N., Kueh, Andrew J., Tai, Lin, Pal, Martin, Strasser, Andreas, Herold, Marco J.

“…Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative genetic…”
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FHL1 promotes chikungunya and o’nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design by Ng, Wern Hann, Liu, Xiang, Ling, Zheng L., Santos, Camilla N. O., Magalhães, Lucas S., Kueh, Andrew J., Herold, Marco J., Taylor, Adam, Freitas, Joseph R., Koit, Sandra, Wang, Sainan, Lloyd, Andrew R., Teixeira, Mauro M., Merits, Andres, Almeida, Roque P., King, Nicholas J. C., Mahalingam, Suresh

“…Arthritogenic alphaviruses are positive-strand RNA viruses that cause debilitating musculoskeletal diseases affecting millions worldwide. A recent discovery…”
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An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles by Kueh, Andrew J, Pal, Martin, Tai, Lin, Liao, Yang, Smyth, Gordon K, Shi, Wei, Herold, Marco J

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Mof (MYST1 or KAT8) Is Essential for Progression of Embryonic Development Past the Blastocyst Stage and Required for Normal Chromatin Architecture by Thomas, Tim, Dixon, Mathew P., Kueh, Andrew J., Voss, Anne K.

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A non‐canonical function of Ezh2 preserves immune homeostasis by Vasanthakumar, Ajithkumar, Xu, Dakang, Lun, Aaron TL, Kueh, Andrew J, van Gisbergen, Klaas PJM, Iannarella, Nadia, Li, Xiaofang, Yu, Liang, Wang, Die, Williams, Bryan RG, Lee, Stanley CW, Majewski, Ian J, Godfrey, Dale I, Smyth, Gordon K, Alexander, Warren S, Herold, Marco J, Kallies, Axel, Nutt, Stephen L, Allan, Rhys S

“…Enhancer of zeste 2 (Ezh2) mainly methylates lysine 27 of histone‐H3 (H3K27me3) as part of the polycomb repressive complex 2 (PRC2) together with Suz12 and…”
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Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects by Delbridge, Alex R.D., Kueh, Andrew J., Ke, Francine, Zamudio, Natasha M., El-Saafin, Farrah, Jansz, Natasha, Wang, Gao-Yuan, Iminitoff, Megan, Beck, Tamara, Haupt, Sue, Hu, Yifang, May, Rose E., Whitehead, Lachlan, Tai, Lin, Chiang, William, Herold, Marco J., Haupt, Ygal, Smyth, Gordon K., Thomas, Tim, Blewitt, Marnie E., Strasser, Andreas, Voss, Anne K.

“…Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs…”
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Role of MXRA8 in Ross River Virus Disease Pathogenesis by Ng, Wern Hann, Ling, Zheng L, Kueh, Andrew J, Herold, Marco J, West, Nicholas P, King, Nicholas J C, Mahalingam, Suresh, Liu, Xiang

“…Arthritogenic alphaviruses such as Ross River virus (RRV) and Chikungunya virus (CHIKV) are responsible for large-scale epidemics that cause debilitating acute…”
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An Erg-driven transcriptional program controls B cell lymphopoiesis by Ng, Ashley P., Coughlan, Hannah D., Hediyeh-zadeh, Soroor, Behrens, Kira, Johanson, Timothy M., Low, Michael Sze Yuan, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Kueh, Andrew J., Boudier, Thomas, Feltham, Rebecca, Gabrielyan, Anna, DiRago, Ladina, Hyland, Craig D., Ierino, Helen, Mifsud, Sandra, Viney, Elizabeth, Willson, Tracy, Dawson, Mark A., Allan, Rhys S., Herold, Marco J., Rogers, Kelly, Tarlinton, David M., Smyth, Gordon K., Davis, Melissa J., Nutt, Stephen L., Alexander, Warren S.

“…B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature B…”
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The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy by Swiderski, Kristy, Chan, Audrey S, Herold, Marco J, Kueh, Andrew J, Chung, Jin D, Hardee, Justin P, Trieu, Jennifer, Chee, Annabel, Naim, Timur, Gregorevic, Paul, Lynch, Gordon S

“…Duchenne muscular dystrophy (DMD) is a devastating monogenic skeletal muscle-wasting disorder. Although many pharmacological and genetic interventions have…”
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Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities by Grabow, Stephanie, Kueh, Andrew J., Ke, Francine, Vanyai, Hannah K., Sheikh, Bilal N., Dengler, Michael A., Chiang, William, Eccles, Samantha, Smyth, Ian M., Jones, Lynelle K., de Sauvage, Frederic J., Scott, Mark, Whitehead, Lachlan, Voss, Anne K., Strasser, Andreas

“…Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The…”
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Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance by Deng, Yexuan, Diepstraten, Sarah T., Potts, Margaret A., Giner, Göknur, Trezise, Stephanie, Ng, Ashley P., Healey, Gerry, Kane, Serena R., Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J., Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S., Visvader, Jane E., Nutt, Stephen L., Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L., Herold, Marco J.

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