Search Results - "Kudoh, Masafumi"

YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts by NAKAHARA, Takahito, TAKEUCHI, Masahiro, SASAMATA, Masao, KINOYAMA, Isao, MINEMATSU, Tsuyoshi, SHIRASUNA, Kenna, MATSUHISA, Akira, KITA, Aya, TOMINAGA, Fumiko, YAMANAKA, Kentaro, KUDOH, Masafumi

“…Various accumulating evidence suggests that survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and…”
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The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice by Mori, Masamichi, Ueno, Yoko, Konagai, Satoshi, Fushiki, Hiroshi, Shimada, Itsuro, Kondoh, Yutaka, Saito, Rika, Mori, Kenichi, Shindou, Nobuaki, Soga, Takatoshi, Sakagami, Hideki, Furutani, Takashi, Doihara, Hitoshi, Kudoh, Masafumi, Kuromitsu, Sadao

“…Activation of anaplastic lymphoma receptor tyrosine kinase (ALK) is involved in the pathogenesis of several carcinomas, including non-small cell lung cancer…”
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YM-359445, an Orally Bioavailable Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor, Has Highly Potent Antitumor Activity against Established Tumors by Amino, Nobuaki, Ideyama, Yukitaka, Yamano, Mayumi, Kuromitsu, Sadao, Tajinda, Katsuinori, Samizu, Kiyohiro, Hisamichi, Hiroyuki, Matsuhisa, Akira, Shirasuna, Kenna, Kudoh, Masafumi, Shibasaki, Masayuki

“…Purpose: The vascular endothelial growth factor receptor-2 (VEGFR2) tyrosine kinase has been implicated in the pathologic angiogenesis associated with tumor…”
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N-Arylpiperazine-1-carboxamide Derivatives: a Novel Series of Orally Active Nonsteroidal Androgen Receptor Antagonists by Kinoyama, Isao, Taniguchi, Nobuaki, Kawaminami, Eiji, Nozawa, Eisuke, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru

“…A novel series of N-arylpiperazine-1-carboxamide derivatives was synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic…”
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A role of androgen receptor protein in cell growth of an androgen-independent prostate cancer cell line by Furutani, T.(Astellas Pharma Inc., Tsukuba, Ibaraki (Japan). Drug Discovery Research), Takeyama, K, Koutoku, H, Ito, S, Taniguchi, N, Suzuki, E, Kudoh, M, Shibasaki, M, Shikama, H, Kato, S

“…Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation…”
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YM-231146, a Novel Orally Bioavailable Inhibitor of Vascular Endothelial Growth Factor Receptor-2, Is Effective against Paclitaxel Resistant Tumors by Amino, Nobuaki, Ideyama, Yukitaka, Yamano, Mayumi, Kuromitsu, Sadao, Tajinda, Katsunori, Samizu, Kiyohiro, Matsuhisa, Akira, Shirasuna, Kenna, Kudoh, Masafumi, Shibasaki, Masayuki

“…Chemotherapy using anticancer drugs induces serious the problem of multidrug resistance (MDR) in the cancer cells. In contrast, endothelial cells so rarely…”
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Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target by Furutani, Takashi, Takeyama, Ken-ichi, Tanabe, Masahiko, Koutoku, Hiroshi, Ito, Saya, Taniguchi, Nobuaki, Suzuki, Eriko, Kudoh, Masafumi, Shibasaki, Masayuki, Shikama, Hisataka, Kato, Shigeaki

“…Androgen receptor (AR) plays key roles in various biological events, including pathological processes such as prostate cancer, androgen-insensitive syndrome,…”
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Synthesis and Pharmacological Evaluation of Novel Arylpiperazine Derivatives as Nonsteroidal Androgen Receptor Antagonists by Kinoyama, Isao, Taniguchi, Nobuaki, Yoden, Toru, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru

“…The search for novel antiandrogens by high-throughput screening (HTS) of the Yamanouchi chemical library led to the discovery of the lead compound (5), which…”
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Studies on Aromatase Inhibitors. I. Synthesis and Biological Evaluation of 4-Amino-4H-1, 2, 4-triazole Derivatives by OKADA, Minoru, YODEN, Toru, KAWAMINAMI, Eiji, SHIMADA, Yoshiaki, KUDOH, Masafumi, ISOMURA, Yasuo, SHIKAMA, Hisataka, FUJIKURA, Takashi

“…Various 4-N-substituted amino-4H-1, 2, 4-triazole derivatives were synthesized and evaluated for aromatase-inhibitory activity (in vitro) and for pregnant mare…”
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Studies on Aromatase Inhibitors. II. Synthesis and Biological Evaluation of 1-Amino-1H-1, 2, 4-triazole Derivatives by OKADA, Minoru, YODEN, Toru, KAWAMINAMI, Eiji, SHIMADA, Yoshiaki, KUDOH, Masafumi, ISOMURA, Yasuo

“…1-N, N-Disubstituted amino-1H-1, 2, 4-triazole derivatives were prepared and evaluated for aromatase-inhibitory activity (in vitro) and for the inhibitory…”
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Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell by Kudoh, Masafumi, Susaki, Yoko, Ideyama, Yukitaka, Nanya, Taiki, Mori, Masamichi, Shikama, Hisataka, Fujikura, Takashi

“…The proliferation of MCF-7, human breast cancer cell line, was stimulated by testosterone and estradiol. The aromatase activity in MCF-7 cells, which catalysed…”
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Studies on Aromatase Inhibitors. III. Synthesis and Biological Evaluation of ((4-Bromobenzyl)(4-cyanophenyl)amino)azoles and Their Azine Analogs by OKADA, Minoru, YODEN, Toru, KAWAMINAMI, Eiji, SHIMADA, Yoshiaki, KUDOH, Masafumi, ISOMURA, Yasuo

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YM-201627: An orally active antitumor agent with selective inhibition of vascular endothelial cell proliferation by Amino, Nobuaki, Ideyama, Yukitaka, Yamano, Mayumi, Kuromitsu, Sadao, Tajinda, Katsunori, Samizu, Kiyohiro, Matsuhisa, Akira, Kudoh, Masafumi, Shibasaki, Masayuki

“…We developed an oral administration-compatible, small molecular weight antitumor agent, YM-201627 by screening for the inhibition of the proliferation of…”
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Bag1 proteins regulate growth and survival of ZR-75-1 human breast cancer cells by KUDOH, Masafumi, KNEE, Deborah A, TAKAYAMA, Shinichi, REED, John C

“…Bag1 proteins bind heat shock protein M(r) 70,000 (Hsp 70) family molecular chaperones and regulate diverse pathways involved in cell proliferation, apoptosis,…”
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(+)-(2R,5S)-4-[4-Cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor Antagonist by Kinoyama, Isao, Taniguchi, Nobuaki, Toyoshima, Akira, Nozawa, Eisuke, Kamikubo, Takashi, Imamura, Masakazu, Matsuhisa, Akira, Samizu, Kiyohiro, Kawanimani, Eiji, Niimi, Tatsuya, Hamada, Noritaka, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru, Ohta, Mitsuaki, Tsukamoto, Shin-ichi

“…A novel series of trans-N-aryl-2,5-dimethylpiperazine-1-carboxamide derivatives was synthesized and their androgen receptor (AR) antagonist activities and in…”
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YM116, 2-(1H-Imidazol-4-ylmethyl)-9H-carbazole, Decreases Adrenal Androgen Synthesis by Inhibiting C17-20 Lyase Activity in NCI-H295 Human Adrenocortical Carcinoma Cells by Ideyama, Yukitaka, Kudoh, Masafumi, Tanimoto, Kyoko, Susaki, Yoko, Nanya, Taiki, Nakahara, Takahito, Ishikawa, Hiroko, Fujikura, Takashi, Akaza, Hideyuki, Shikama, Hisataka

“…The concentrations of androstenedione and dehydroepiandrosterone, products of C17-20 lyase, in the medium after a 6-hr incubation of NCI-H295 cells were…”
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Stabilization of androgen receptor protein is induced by agonist, not by antagonists by Furutani, Takashi, Watanabe, Tomoyuki, Tanimoto, Kyouko, Hashimoto, Takamichi, Koutoku, Hiroshi, Kudoh, Masafumi, Shimizu, Yasuaki, Kato, Shigeaki, Shikama, Hisataka

“…The action of nuclear receptor ligands in target tissues is specified mainly by the expression levels of their cognate nuclear receptors. The expression levels…”
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YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine klinase inhibitor, has highly potent antitumor activity against established tumors by AMINO, Nobuaki, IDEYAMA, Yukitaka, SHIBASAKI, Masayuki, YAMANO, Mayumi, KUROMITSU, Sadao, TAJINDA, Katsuinori, SAMIZU, Kiyohiro, HISAMICHI, Hiroyuki, MATSUHISA, Akira, SHIRASUNA, Kenna, KUDOH, Masafumi

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N-Arylpiperazine-1-carboxamide Derivatives by Kinoyama, Isao, Taniguchi, Nobuaki, Kawaminami, Eiji, Nozawa, Eisuke, Koutoku, Hiroshi, Furutani, Takashi, Kudoh, Masafumi, Okada, Minoru

“…A novel series of N-arylpiperazine-1-carboxamide derivatives was synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic…”
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YM116, 2-(1H-Imidazol-4-ylmethyl)-9H-carbazole, Decreases Adrenal Androgen Synthesis by Inhibiting Cl7-20 Lyase Activity in NCI-H295 Human Adrenocortical Carcinoma Cells by Yukitaka, Ideyama, Masafumi, Kudoh, Kyoko, Tanimoto, Yoko, Susaki, Taiki, Nanya, Takahito, Nakahara, Hiroko, Ishikawa, Takashi, Fujikura, Hideyuki, Akaza, Hisataka, Shikama

“…The concentrations of androstenedione and dehydroepiandrosterone, products of C17-20 lyase, in the medium after a 6-hr incubation of NCI-H295 cells were…”
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