Search Results - "Kudlacek, Stephan"

Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance by Liu, Can, Zhou, Jiawei, Kudlacek, Stephan, Qi, Timothy, Dunlap, Tyler, Cao, Yanguang

“…Effector T cells need to form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal…”
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High-resolution epitope mapping of commercial antibodies to ANCA antigens by yeast surface display by Poulton, John S., Lamba, Sajan, Free, Meghan, Xi, Gang, McInnis, Elizabeth, Williams, Gabrielle, Kudlacek, Stephan T., Thieker, David, Kuhlman, Brian, Falk, Ronald

“…Epitope mapping provides critical insight into antibody-antigen interactions. Epitope mapping of autoantibodies from patients with autoimmune diseases can help…”
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Stabilizing proteins, simplified: A Rosetta‐based webtool for predicting favorable mutations by Thieker, David F., Maguire, Jack B., Kudlacek, Stephan T., Leaver‐Fay, Andrew, Lyskov, Sergey, Kuhlman, Brian

“…Many proteins have low thermodynamic stability, which can lead to low expression yields and limit functionality in research, industrial and clinical settings…”
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Focused dengue vaccine development: outwitting nature's design by Kudlacek, Stephan T, Metz, Stefan W

“…ABSTRACT The four DENV serotypes are mosquito-borne pathogens that belong to the Flavivirus genus. These viruses present a major global health burden, being…”
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A conserved set of mutations for stabilizing soluble envelope protein dimers from dengue and Zika viruses to advance the development of subunit vaccines by Phan, Thanh T.N., Hvasta, Matthew G., Kudlacek, Stephan T., Thiono, Devina J., Tripathy, Ashutosh, Nicely, Nathan I., de Silva, Aravinda M., Kuhlman, Brian

“…Dengue viruses (DENV serotypes 1–4) and Zika virus (ZIKV) are closely related flaviviruses that continue to be a global public health concern, infecting…”
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Shear-Stress-Mediated Refolding of Proteins from Aggregates and Inclusion Bodies by Yuan, Tom Z., Ormonde, Callum F. G., Kudlacek, Stephan T., Kunche, Sameeran, Smith, Joshua N., Brown, William A., Pugliese, Kaitlin M., Olsen, Tivoli J., Iftikhar, Mariam, Raston, Colin L., Weiss, Gregory A.

“…Recombinant protein overexpression of large proteins in bacteria often results in insoluble and misfolded proteins directed to inclusion bodies. We report the…”
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Dimerization of Dengue Virus E Subunits Impacts Antibody Function and Domain Focus by Thomas, Ashlie, Thiono, Devina J, Kudlacek, Stephan T, Forsberg, John, Premkumar, Lakshmanane, Tian, Shaomin, Kuhlman, Brian, de Silva, Aravinda M, Metz, Stefan W

“…Dengue virus (DENV) is responsible for the most prevalent and significant arthropod-borne viral infection of humans. The leading DENV vaccines are based on…”
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Virus-Enabled Biosensor for Human Serum Albumin by Ogata, Alana F, Edgar, Joshua M, Majumdar, Sudipta, Briggs, Jeffrey S, Patterson, Shae V, Tan, Ming X, Kudlacek, Stephan T, Schneider, Christine A, Weiss, Gregory A, Penner, Reginald M

“…The label-free detection of human serum albumin (HSA) in aqueous buffer is demonstrated using a simple, monolithic, two-electrode electrochemical biosensor. In…”
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Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins by Kudlacek, Stephan T., Premkumar, Lakshmanane, Metz, Stefan W., Tripathy, Ashutosh, Bobkov, Andrey A., Payne, Alexander Matthew, Graham, Stephen, Brackbill, James A., Miley, Michael J., de Silva, Aravinda M., Kuhlman, Brian

“…The spread of dengue (DENV) and Zika virus (ZIKV) is a major public health concern. The primary target of antibodies that neutralize DENV and ZIKV is the…”
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Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies by Kudlacek, Stephan T, Metz, Stefan, Thiono, Devina, Payne, Alexander M, Phan, Thanh T N, Tian, Shaomin, Forsberg, Lawrence J, Maguire, Jack, Seim, Ian, Zhang, Shu, Tripathy, Ashutosh, Harrison, Joseph, Nicely, Nathan I, Soman, Sandrine, McCracken, Michael K, Gromowski, Gregory D, Jarman, Richard G, Premkumar, Lakshmanane, de Silva, Aravinda M, Kuhlman, Brian

“…Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed. Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E)…”
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Computer-Based Design and Stabilization of the Dengue Virus Envelope Protein for Use as a Subunit Vaccine by Kudlacek, Stephan Timothy

“…Dengue virus (DENV) is a highly prevalent, multi-serotype arbovirus whose infections present a worldwide public health burden with the need of vaccines capable…”
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Measuring quality of life with the German Osteoporosis Quality of Life Questionnaire in women with osteoporosis by Kerschan-Schindl, Katharina, Patsch, Janina, Kudlacek, Stephan, Gleiss, Andreas, Pietschmann, Peter

“…Summary Objective To evaluate quality of life in women suffering with osteoporosis with or without vertebral fractures for the first time with the German…”
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The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism by Pietschmann, Peter, Gollob, Eva, Brosch, Susanne, Hahn, Philipp, Kudlacek, Stephan, Willheim, Martin, Woloszczuk, Wolfgang, Peterlik, Meinrad, Tragl, Karl Heinz

“…Background. Aging has been associated with various alterations of immune functions, the musculoskeletal system and a decline of sex hormone levels. Estradiol…”
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