Search Results - "Kuder, Kamil J"

Perry Disease: Current Outlook and Advances in Drug Discovery Approach to Symptomatic Treatment by Gajda, Zbigniew, Hawrylak, Magdalena, Handzlik, Jadwiga, Kuder, Kamil J

“…Perry disease (PeD) is a rare, neurodegenerative, genetic disorder inherited in an autosomal dominant manner. The disease manifests as parkinsonism, with…”
Get full text

Structure Prediction, Evaluation, and Validation of GPR18 Lipid Receptor Using Free Programs by Michalik, Ilona, Kuder, Kamil J., Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga

“…The GPR18 receptor, often referred to as the N-arachidonylglycine receptor, although assigned (along with GPR55 and GPR119) to the new class A GPCR…”
Get full text

The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice by Abdalla, Sabna, Eissa, Nermin, Jayaprakash, Petrilla, Beiram, Rami, Kuder, Kamil J, Łażewska, Dorota, Kieć-Kononowicz, Katarzyna, Sadek, Bassem

“…The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g.,…”
Get full text

Discovery of Potential, Dual-Active Histamine H3 Receptor Ligands with Combined Antioxidant Properties by Kuder, Kamil J., Kotańska, Magdalena, Szczepańska, Katarzyna, Mika, Kamil, Reiner-Link, David, Stark, Holger, Kieć-Kononowicz, Katarzyna

“…In an attempt to find new dual acting histamine H3 receptor (H3R) ligands, we designed a series of compounds, structurally based on previously described in our…”
Get full text

AR71, Histamine H3 Receptor Ligand—In Vitro and In Vivo Evaluation (Anti-Inflammatory Activity, Metabolic Stability, Toxicity, and Analgesic Action) by Stasiak, Anna, Honkisz-Orzechowska, Ewelina, Gajda, Zbigniew, Wagner, Waldemar, Popiołek-Barczyk, Katarzyna, Kuder, Kamil J., Latacz, Gniewomir, Juszczak, Michał, Woźniak, Katarzyna, Karcz, Tadeusz, Szczepańska, Katarzyna, Jóźwiak-Bębenista, Marta, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota

“…The future of therapy for neurodegenerative diseases (NDs) relies on new strategies targeting multiple pharmacological pathways. Our research led to obtaining…”
Get full text

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity by Załuski, Michał, Łażewska, Dorota, Jaśko, Piotr, Honkisz-Orzechowska, Ewelina, Kuder, Kamil J., Brockmann, Andreas, Latacz, Gniewomir, Zygmunt, Małgorzata, Kaleta, Maria, Greser, Beril Anita, Olejarz-Maciej, Agnieszka, Jastrzębska-Więsek, Magdalena, Vielmuth, Christin, Müller, Christa E., Kieć-Kononowicz, Katarzyna

“…Chronic inflammation plays an important role in the development of neurodegenerative diseases, such as Parkinson’s disease (PD). In the present study, we…”
Get full text

Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer’s Disease by Godyń, Justyna, Zaręba, Paula, Stary, Dorota, Kaleta, Maria, Kuder, Kamil J., Latacz, Gniewomir, Mogilski, Szczepan, Reiner-Link, David, Frank, Annika, Doroz-Płonka, Agata, Olejarz-Maciej, Agnieszka, Sudoł-Tałaj, Sylwia, Nolte, Tobias, Handzlik, Jadwiga, Stark, Holger, Więckowska, Anna, Malawska, Barbara, Kieć-Kononowicz, Katarzyna, Łażewska, Dorota, Bajda, Marek

“…The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising…”
Get full text

Fluorescent GPCR ligands as new tools in pharmacology-update, years 2008-early 2014 by Kuder, Kamil J, Kieć-Kononowicz, Katarzyna

“…The robust of fluorescent techniques to study the ligand-receptor interaction followed by rapidly developing fluorescence imaging techniques resulted in a…”
Get more information

Histamine H3 Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating by Mika, Kamil, Szafarz, Małgorzata, Bednarski, Marek, Latacz, Gniewomir, Sudoł, Sylwia, Handzlik, Jadwiga, Pociecha, Krzysztof, Knutelska, Joanna, Nicosia, Noemi, Szczepańska, Katarzyna, Kuder, Kamil J., Kieć-Kononowicz, Katarzyna, Kotańska, Magdalena

“…Noting the worldwide rapid increase in the prevalence of overweight and obesity new effective drugs are now being sought to combat these diseases. Histamine H3…”
Get full text

Docking Foundations: From Rigid to Flexible Docking by Kuder, Kamil J

“…Despite the development of methods for the experimental determination of protein structures, the dissonance between the number of known sequences and their…”
Get more information

Dual-targeting Approach on Histamine H 3 and Sigma-1 Receptor Ligands as Promising Pharmacological Tools in the Treatment of CNS-linked Disorders by Szczepańska, Katarzyna, Kuder, Kamil J, Kieć-Kononowicz, Katarzyna

“…With the recent market approval of Pitolisant (Wakix®), the interest in clinical application for novel multifunctional histamine H receptor antagonists has…”
Get more information

Machine Learning Methods in Protein-Protein Docking by Michalik, Ilona, Kuder, Kamil J

“…An exponential increase in the number of publications that address artificial intelligence (AI) usage in life sciences has been noticed in recent years, while…”
Get more information

The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice by Kotańska, Magdalena, Kuder, Kamil J., Szczepańska, Katarzyna, Sapa, Jacek, Kieć-Kononowicz, Katarzyna

“…The pharmacological profile of pitolisant, a histamine H 3 receptor antagonist/inverse agonist, indicates that this compound might reduce body weight and…”
Get full text

N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H 3 receptor and cancer resistance proteins by Szczepańska, Katarzyna, Kincses, Annamária, Vincze, Klaudia, Szymańska, Ewa, Latacz, Gniewomir, Kuder, Kamil J, Stark, Holger, Spengler, Gabriella, Handzlik, Jadwiga, Kieć-Kononowicz, Katarzyna

“…Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer treatment, the ability of novel histamine H…”
Get full text

N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins by Szczepańska, Katarzyna, Kincses, Annamária, Vincze, Klaudia, Szymańska, Ewa, Latacz, Gniewomir, Kuder, Kamil J., Stark, Holger, Spengler, Gabriella, Handzlik, Jadwiga, Kieć-Kononowicz, Katarzyna

“…[Display omitted] •ABCB1 efflux pump modulating assays in mouse T-lymphoma cells for compounds 1–18.•Cytotoxicity and proliferation assays in PAR and MDR…”
Get full text

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands by Szczepańska, Katarzyna, Karcz, Tadeusz, Mogilski, Szczepan, Siwek, Agata, Kuder, Kamil J., Latacz, Gniewomir, Kubacka, Monika, Hagenow, Stefanie, Lubelska, Annamaria, Olejarz, Agnieszka, Kotańska, Magdalena, Sadek, Bassem, Stark, Holger, Kieć-Kononowicz, Katarzyna

“…As a continuation of our search for novel histamine H3 receptor ligands, a series of twenty four new tert-butyl and tert-pentyl phenoxyalkylamine derivatives…”
Get full text

Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent by Szczepańska, Katarzyna, Pockes, Steffen, Podlewska, Sabina, Höring, Carina, Mika, Kamil, Latacz, Gniewomir, Bednarski, Marek, Siwek, Agata, Karcz, Tadeusz, Nagl, Martin, Bresinsky, Merlin, Mönnich, Denise, Seibel, Ulla, Kuder, Kamil J., Kotańska, Magdalena, Stark, Holger, Elz, Sigurd, Kieć-Kononowicz, Katarzyna

“…A series of 4-pyridylpiperazine derivatives with varying regulatory region substituents proved to be potent histamine H3 receptor (H3R) ligands in the…”
Get full text

Structural modifications in the distal, regulatory region of histamine H 3 receptor antagonists leading to the identification of a potent anti-obesity agent by Szczepańska, Katarzyna, Pockes, Steffen, Podlewska, Sabina, Höring, Carina, Mika, Kamil, Latacz, Gniewomir, Bednarski, Marek, Siwek, Agata, Karcz, Tadeusz, Nagl, Martin, Bresinsky, Merlin, Mönnich, Denise, Seibel, Ulla, Kuder, Kamil J, Kotańska, Magdalena, Stark, Holger, Elz, Sigurd, Kieć-Kononowicz, Katarzyna

“…A series of 4-pyridylpiperazine derivatives with varying regulatory region substituents proved to be potent histamine H receptor (H R) ligands in the nanomolar…”
Get full text

The histamine H 3 receptor inverse agonist pitolisant reduces body weight in obese mice by Kotańska, Magdalena, Kuder, Kamil J, Szczepańska, Katarzyna, Sapa, Jacek, Kieć-Kononowicz, Katarzyna

“…The pharmacological profile of pitolisant, a histamine H receptor antagonist/inverse agonist, indicates that this compound might reduce body weight and…”
Get full text

Optimization and preclinical evaluation of novel histamine H 3 receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives by Szczepańska, Katarzyna, Karcz, Tadeusz, Kotańska, Magdalena, Siwek, Agata, Kuder, Kamil J, Latacz, Gniewomir, Mogilski, Szczepan, Hagenow, Stefanie, Lubelska, Annamaria, Sobolewski, Michał, Stark, Holger, Kieć-Kononowicz, Katarzyna

“…As a continuation of our search for novel histamine H receptor ligands, a series of new acetyl and propionyl phenoxyalkylamine derivatives (2-25) was…”
Get full text