Search Results - "Kuder, Craig"

3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines by Kuder, Craig H, Weivoda, Megan M, Zhang, Ying, Zhu, Junjia, Neighbors, Jeffrey D, Wiemer, David F, Hohl, Raymond J

“…The schweinfurthins have potent antiproliferative activity in multiple glioblastoma multiforme (GBM) cell lines; however, the mechanism by which growth is…”
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Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil by Sheehy, Ryan M, Kuder, Craig H, Bachman, Zoe, Hohl, Raymond J

“…Schweinfurthins are intriguing natural products with anti-cancer activities and as yet incompletely understood mechanisms of action. We investigated whether…”
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Quantitative determination of isopentenyl diphosphate in cultured mammalian cells by Tong, Huaxiang, Kuder, Craig H., Wasko, Brian M., Hohl, Raymond J.

“…Isopentenyl diphosphate (IPP), an intermediate of the isoprenoid biosynthetic pathway (IBP), has several important biological functions, yet a method to…”
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In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors by Reilly, Jacqueline E., Zhou, Xiang, Tong, Huaxiang, Kuder, Craig H., Wiemer, David F., Hohl, Raymond J.

“…A small set of isoprenoid bisphosphonates ethers has been tested in the K562 chronic myelogenous leukemia cell line to determine their impact on isoprenoid…”
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Pleiotropic Effects of a Schweinfurthin on Isoprenoid Homeostasis by Holstein, Sarah A., Kuder, Craig H., Tong, Huaxiang, Hohl, Raymond J.

“…The schweinfurthins, a family of natural products derived from the isoprenoid biosynthetic pathway (IBP), have marked growth inhibitory activity. However, the…”
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Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification by Kuder, Craig H, Sheehy, Ryan M, Neighbors, Jeffrey D, Wiemer, David F, Hohl, Raymond J

“…Schweinfurthins are potent inhibitors of cancer cell growth, especially against human central nervous system tumor lines such as SF-295 cells. However, the…”
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Synthesis and biological activity of a fluorescent schweinfurthin analogue by Kuder, Craig H., Neighbors, Jeffrey D., Hohl, Raymond J., Wiemer, David F.

“…Synthesis of a fluorescent schweinfurthin analogue has been accomplished, and its biological activity and sub-cellular localization have been studied. Most of…”
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Biologically active biotin derivatives of schweinfurthin F by Ulrich, Natalie C., Kuder, Craig H., Hohl, Raymond J., Wiemer, David F.

“…As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been…”
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Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure by Ulrich, Natalie C., Kodet, John G., Mente, Nolan R., Kuder, Craig H., Beutler, John A., Hohl, Raymond J., Wiemer, David F.

“…Synthesis of a set of schweinfurthin analogues varied in the D-ring alkyl substituent and stilbene moiety has been accomplished, and the activity of these…”
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Quantitative Determination of Geranyl Diphosphate Levels in Cultured Human Cells by Holstein, Sarah A, Tong, Huaxiang, Kuder, Craig H, Hohl, Raymond J

“…Geranyl diphosphate (GPP), a 10-carbon isoprenoid, is a key intermediate in the isoprenoid biosynthetic pathway. This pathway, in addition to leading to sterol…”
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Fluorescent schweinfurthin B and F analogs with anti-proliferative activity by Topczewski, Joseph J., Kuder, Craig H., Neighbors, Jeffrey D., Hohl, Raymond J., Wiemer, David F.

“…The synthesis of several new fluorescent analogs of schweinfurthins B and F is described, along with assays that demonstrates that these compounds retain…”
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Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation by Maalouf, Mona A., Wiemer, Andrew J., Kuder, Craig H., Hohl, Raymond J., Wiemer, David F.

“…Geminal bisphosphonates can be used for a variety of purposes in human disease including reduction of bone resorption in osteoporosis, treatment of fractures…”
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Treatment and outcomes of patients with advanced gastric, esophageal, or gastroesophageal junction adenocarcinoma in the United States by Barzi, Afsaneh, Hess, Lisa, Zhu, Yajun, Liepa, Astra, Fang, Yun, Kuder, Craig, Beyrer, Julie, Chao, Joseph

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Real-world outcomes and patient (pt) characteristics for the second-line (2L) treatment of gastric, esophageal, or gastroesophageal junction (GEJ) adenocarcinoma (EGAC) by Barzi, Afsaneh, Hess, Lisa M., Zhu, Yajun, Liepa, Astra M., Fang, Yun, Kuder, Craig Heath, Beyrer, Julie, Chao, Joseph

“…Abstract only…”
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Dissecting The Effects Of Isoprenoid Pathway Inhibition On Hemostasis and Thrombosis: Differential Effects Of Atorvastatin and Digeranyl Bisphosphonate In Hypercholesterolemic Mice by Bhasin, Neha, Stevens, Jeff, Niki, Masaru, Tong, Huaxiang, Kuder, Craig, Hohl, Raymond J., Lentz, Steven R

“…Statins inhibit HMG-CoA reductase, leading to decreased production of cholesterol and isoprenoid metabolites. There is growing evidence that statins have…”
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Abstract 4032: Targeting the isoprenoid biosynthetic pathway in a murine model of metastatic prostate cancer by Reilly, Jacqueline E., Neighbors, Jeffrey D., Bannick, Nadine, Henry, Michael D., Kuder, Craig H., Hohl, Raymond J.

“…The isoprenoid biosynthetic pathway (IBP) provides substrates for the post-translational modification of key proteins in regulating malignant cell properties,…”
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Abstract 170: Differential Effects of Atorvastatin and Digeranyl Bisphosphonate on Hemostasis and Thrombosis in Hypercholesterolemic Mice by Bhasin, Neha, Stevens, Jeff W, Niki, Masaru, Tong, Huaxiang, Kuder, Craig H, Hohl, Raymond J, Lentz, Steven R

“…Abstract only…”
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Schweinfurthins as novel anticancer agents by Kuder, Craig Heath

“…Several members of the schweinfurthin family are potent and selective inhibitors of cancer cell growth in the NCI 60-cell cancer screen. The schweinfurthins…”
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Schweinfurthins as novel anticancer agents by Kuder, Craig Heath

“…Several members of the schweinfurthin family are potent and selective inhibitors of cancer cell growth in the NCI 60-cell cancer screen. The schweinfurthins…”
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