Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

The methods used for digital processing of optical coherence tomography (OCT) and crosspolarization (CP) OCT images are focused on improving the contrast ratio of native structural OCT images. Such advances are particularly important for the intraoperative detection of glioma margins where the visua...

Full description

Saved in:

Bibliographic Details
Published in:	Neurophotonics (Print) Vol. 6; no. 3; p. 035003
Main Authors:	Kiseleva, Elena B, Yashin, Konstantin S, Moiseev, Alexander A, Timofeeva, Lidia B, Kudelkina, Vera V, Alekseeva, Anna I, Meshkova, Svetlana V, Polozova, Anastasia V, Gelikonov, Grigory V, Zagaynova, Elena V, Gladkova, Natalia D
Format:	Journal Article
Language:	English
Published:	United States Society of Photo-Optical Instrumentation Engineers 01-07-2019 S P I E - International Society for
Subjects:	Brain cancer Brain mapping Glioblastoma Research Papers Substantia alba Substantia grisea Tomography Tumors Russia brain imaging image processing crosspolarization optical coherence tomography glioblastoma model optical coefficients white and gray matter
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The methods used for digital processing of optical coherence tomography (OCT) and crosspolarization (CP) OCT images are focused on improving the contrast ratio of native structural OCT images. Such advances are particularly important for the intraoperative detection of glioma margins where the visual assessment of OCT images can be difficult and lead to errors. The aim of the study was to investigate the application of optical coefficients obtained from CP OCT data for the differentiation of glial tumorous tissue from a normal brain. Pseudocolor en-face OCT maps based on two optical coefficients (the commonly used rate of attenuation in the cochannel, and in addition, the interchannel attenuation difference) were constructed for normal rat brain coronal cross sections and for brains with a 101.8 rat glioblastoma model. It was shown that the use of optical coefficients significantly increased the available information from the OCT data in comparison with unprocessed images. As a result, this allowed contrasting of the white matter from the gray matter and tumorous tissue ex vivo, and for this purpose, the interchannel attenuation difference worked better. The interchannel attenuation difference values of white matter were at least seven and two times higher than corresponding values of the cortex and tumorous tissue, whereas the same parameter for cochannel attenuation coefficient values of white matter are about 4 and 1.4. However, quantitative analysis shows that both coefficients are suitable for the purpose of glioblastoma detection from normal brain tissue regardless of whether a necrotic component was present (in all compared groups p < 0.001).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2329-423X 2329-4248
DOI:	10.1117/1.NPh.6.3.035003