Search Results - "Kudchodkar, Sagar"

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery by Tang, Li, Zheng, Yiran, Melo, Mariane Bandeira, Mabardi, Llian, Castaño, Ana P, Xie, Yu-Qing, Li, Na, Kudchodkar, Sagar B, Wong, Hing C, Jeng, Emily K, Maus, Marcela V, Irvine, Darrell J

“…Cytokines released after T cell activation improve the efficacy of T cell therapies in mice. Adoptive cell therapy (ACT) with antigen-specific T cells has…”
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Viruses and autophagy by Kudchodkar, Sagar B., Levine, Beth

“…Autophagy is an evolutionarily conserved intracellular process by which bulk cytoplasm is enveloped inside a double‐membraned vesicle and shuttled to lysosomes…”
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Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine by Tebas, Pablo, Roberts, Christine C, Muthumani, Kar, Reuschel, Emma L, Kudchodkar, Sagar B, Zaidi, Faraz I, White, Scott, Khan, Amir S, Racine, Trina, Choi, Hyeree, Boyer, Jean, Park, Young K, Trottier, Sylvie, Remigio, Celine, Krieger, Diane, Spruill, Susan E, Bagarazzi, Mark, Kobinger, Gary P, Weiner, David B, Maslow, Joel N

“…There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study…”
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Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia by Fraietta, Joseph A., Beckwith, Kyle A., Patel, Prachi R., Ruella, Marco, Zheng, Zhaohui, Barrett, David M., Lacey, Simon F., Melenhorst, Jan Joseph, McGettigan, Shannon E., Cook, Danielle R., Zhang, Changfeng, Xu, Jun, Do, Priscilla, Hulitt, Jessica, Kudchodkar, Sagar B., Cogdill, Alexandria P., Gill, Saar, Porter, David L., Woyach, Jennifer A., Long, Meixiao, Johnson, Amy J., Maddocks, Kami, Muthusamy, Natarajan, Levine, Bruce L., June, Carl H., Byrd, John C., Maus, Marcela V.

“…Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is highly promising but requires robust T-cell expansion and engraftment. A T-cell defect in chronic…”
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Protective immunity by an engineered DNA vaccine for Mayaro virus by Choi, Hyeree, Kudchodkar, Sagar B, Reuschel, Emma L, Asija, Kanika, Borole, Piyush, Ho, Michelle, Wojtak, Krzysztof, Reed, Charles, Ramos, Stephanie, Bopp, Nathen E, Aguilar, Patricia V, Weaver, Scott C, Kim, J Joseph, Humeau, Laurent, Tebas, Pablo, Weiner, David B, Muthumani, Kar

“…Mayaro virus (MAYV) of the genus alphavirus is a mosquito-transmitted emerging infectious disease that causes an acute febrile illness, rash, headaches, and…”
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Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants by Flingai, Seleeke, Czerwonko, Matias, Goodman, Jonathan, Kudchodkar, Sagar B, Muthumani, Kar, Weiner, David B

“…In recent years, DNA vaccines have undergone a number of technological advancements that have incited renewed interest and heightened promise in the field. Two…”
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A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus by Choi, Hyeree, Kudchodkar, Sagar B, Ho, Michelle, Reuschel, Emma L, Reynolds, Erin, Xu, Ziyang, Bordoloi, Devivasha, Ugen, Kenneth E, Tebas, Pablo, Kim, Joseph, Abdel-Mohsen, Mohamed, Thangamani, Saravanan, Weiner, David B, Muthumani, Kar

“…Powassan virus (POWV) infection is a tick-borne emerging infectious disease in the United States and North America. Like Zika virus, POWV is a member of the…”
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Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics by Khoshnejad, Makan, Patel, Ami, Wojtak, Krzysztof, Kudchodkar, Sagar B., Humeau, Laurent, Lyssenko, Nicholas N., Rader, Daniel J., Muthumani, Kar, Weiner, David B.

“…Elevated low-density lipoprotein cholesterol (LDL-C) is one of the major contributors to cardiovascular heart disease (CHD), the leading cause of death…”
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In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus by Esquivel, Rianne N., Patel, Ami, Kudchodkar, Sagar B., Park, Daniel H., Stettler, Karin, Beltramello, Martina, Allen, Jeffrey W., Mendoza, Janess, Ramos, Stephanie, Choi, Hyeree, Borole, Piyush, Asija, Kanika, Bah, Mamadou, Shaheen, Shareef, Chen, Jing, Yan, Jian, Durham, Amy C., Smith, Trevor R.F., Broderick, Kate, Guibinga, Ghiabe, Muthumani, Kar, Corti, Davide, Humeau, Laurent, Weiner, David B.

“…Zika virus (ZIKV) infection is endemic to several world regions, and many others are at high risk for seasonal outbreaks. Synthetic DNA-encoded monoclonal…”
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Safety and immunogenicity of the bi-cistronic GLS-5310 COVID-19 DNA vaccine delivered with the GeneDerm suction device by Kim, Woo Joo, Roberts, Christine C., Song, Joon Young, Yoon, Jin Gu, Seong, Hye, Hyun, Hak-Jun, Lee, Hyojin, Gil, Areum, Oh, Yeeun, Park, Ji-eun, Jeon, Bohyun, Lee, Ji-Eun, Choi, Sang Kyu, Yoon, Sun Kyung, Lee, Sunhee, Kim, Byoungguk, Kane, Deborah, Spruill, Susan, Kudchodkar, Sagar B., Muthumani, Kar, Park, Young K., Kwon, Ijoo, Jeong, Moonsup, Maslow, Joel N.

“…•This study reports the safety and immunogenicity of the GLS-5310 DNA vaccine through 48 weeks.•First clinical application of the GeneDerm suction device for…”
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Immune response enhancement with GLS-5310 DNA primary vaccine against SARS-CoV-2 followed by administration of an mRNA vaccine heterologous boost by Kim, Woo Joo, Roberts, Christine C., Song, Joon Young, Yoon, Jin Gu, Seong, Hye, Hyun, Hak-Jun, Lee, Hyojin, Gil, Areum, Oh, Yeeun, Park, Ji-Eun, Lee, Ji-Eun, Jeon, Bohyun, Kane, Deborah, Spruill, Susan, Kudchodkar, Sagar B., Muthumani, Kar, Park, Young K., Kwon, Ijoo, Maslow, Joel N.

“…•Heterologous mRNA boost following GLS-5310 DNA vaccination was well tolerated.•Neutralizing antibody responses were enhanced 110 fold to GMT of…”
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Rapid response to an emerging infectious disease – Lessons learned from development of a synthetic DNA vaccine targeting Zika virus by Kudchodkar, Sagar B., Choi, Hyeree, Reuschel, Emma L., Esquivel, Rianne, Jin-Ah Kwon, Jackie, Jeong, Moonsup, Maslow, Joel N., Reed, Charles C., White, Scott, Kim, J. Joseph, Kobinger, Gary P., Tebas, Pablo, Weiner, David B., Muthumani, Kar

“…Vaccines are considered one of the greatest advances in modern medicine. The global burden of numerous infectious diseases has been significantly reduced, and…”
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Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in Immunotherapy by Chung, Christopher, Kudchodkar, Sagar B, Chung, Curtis N, Park, Young K, Xu, Ziyang, Pardi, Norbert, Abdel-Mohsen, Mohamed, Muthumani, Kar

“…Harnessing the immune system to combat disease has revolutionized medical treatment. Monoclonal antibodies (mAbs), in particular, have emerged as important…”
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DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond by Maslow, Joel N, Kwon, Ijoo, Kudchodkar, Sagar B, Kane, Deborah, Tadesse, Amha, Lee, Hyojin, Park, Young K, Muthumani, Kar, Roberts, Christine C

“…We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA…”
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Multivalent DNA Vaccines as A Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses by Jiang, Jingjing, Ramos, Stephanie J, Bangalore, Preeti, Elwood, Dustin, Cashman, Kathleen A, Kudchodkar, Sagar B, Schultheis, Katherine, Pugh, Holly, Walters, Jewell, Tur, Jared, Yan, Jian, Patel, Ami, Muthumani, Kar, Schmaljohn, Connie S, Weiner, David B, Humeau, Laurent M, Broderick, Kate E

“…The emergence of multiple concurrent infectious diseases localized in the world creates a complex burden on global public health systems. Outbreaks of Ebola,…”
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Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation by Novikova, Mariia, Adams, Lucas J, Fontana, Juan, Gres, Anna T, Balasubramaniam, Muthukumar, Winkler, Dennis C, Kudchodkar, Sagar B, Soheilian, Ferri, Sarafianos, Stefan G, Steven, Alasdair C, Freed, Eric O

“…Late in the HIV-1 replication cycle, the viral structural protein Gag is targeted to virus assembly sites at the plasma membrane of infected cells. The capsid…”
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Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial by Modjarrad, Kayvon, Roberts, Christine C, Mills, Kristin T, Castellano, Amy R, Paolino, Kristopher, Muthumani, Kar, Reuschel, Emma L, Robb, Merlin L, Racine, Trina, Oh, Myoung-don, Lamarre, Claude, Zaidi, Faraz I, Boyer, Jean, Kudchodkar, Sagar B, Jeong, Moonsup, Darden, Janice M, Park, Young K, Scott, Paul T, Remigio, Celine, Parikh, Ajay P, Wise, Megan C, Patel, Ami, Duperret, Elizabeth K, Kim, Kevin Y, Choi, Hyeree, White, Scott, Bagarazzi, Mark, May, Jeanine M, Kane, Deborah, Lee, Hyojin, Kobinger, Gary, Michael, Nelson L, Weiner, David B, Thomas, Stephen J, Maslow, Joel N

“…Middle East respiratory syndrome (MERS) coronavirus causes a highly fatal lower-respiratory tract infection. There are as yet no licensed MERS vaccines or…”
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Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes by Kudchodkar, Sagar B, Yu, Yongjun, Maguire, Tobi G, Alwine, James C

“…Signaling mediated by the mammalian target of rapamycin kinase (mTOR) is activated during human cytomegalovirus (HCMV) infection. mTOR is found in two…”
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In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine by Muthumani, Karuppiah, Griffin, Bryan D, Agarwal, Sangya, Kudchodkar, Sagar B, Reuschel, Emma L, Choi, Hyeree, Kraynyak, Kimberly A, Duperret, Elizabeth K, Keaton, Amelia Anne, Chung, Christopher, Kim, Yinho K, Booth, Stephanie A, Racine, Trina, Yan, Jian, Morrow, Matthew P, Jiang, Jingjing, Lee, Brian, Ramos, Stephanie, Broderick, Kate E, Reed, Charles C, Khan, Amir S, Humeau, Laurent, Ugen, Kenneth E, Park, Young K, Maslow, Joel N, Sardesai, Niranjan Y, Joseph Kim, J, Kobinger, Gary P, Weiner, David B

“…Significant concerns have been raised owing to the rapid global spread of infection and disease caused by the mosquito-borne Zika virus (ZIKV). Recent studies…”
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Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody by Muthumani, Kar, Marnin, Liron, Kudchodkar, Sagar B., Perales-Puchalt, Alfredo, Choi, Hyeree, Agarwal, Sangya, Scott, Veronica L., Reuschel, Emma L., Zaidi, Faraz I., Duperret, Elizabeth K., Wise, Megan C., Kraynyak, Kimberly A., Ugen, Kenneth. E., Sardesai, Niranjan Y., Joseph Kim, J., Weiner, David B.

“…Prostate-specific membrane antigen (PSMA) is expressed at high levels on malignant prostate cells and is likely an important therapeutic target for the…”
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