Search Results - "Kudchadkar, R"

Large language models and the perils of their hallucinations by Azamfirei, Razvan, Kudchadkar, Sapna R, Fackler, James

“…[...]one of the trials included in the summary, Belohlavek et al. [...]we will improve our ability to integrate real-time information and reduce the rate of…”
Get full text

Predictive and on-treatment monitoring biomarkers in advanced melanoma: Moving toward personalized medicine by Tarhini, Ahmad, Kudchadkar, Ragini R.

“…•Validated biomarkers predictive for response to therapy are needed in melanoma.•Baseline immune biomarkers are emerging to personalize therapeutic…”
Get full text

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain by Tawbi, Hussein A, Forsyth, Peter A, Algazi, Alain, Hamid, Omid, Hodi, F. Stephen, Moschos, Stergios J, Khushalani, Nikhil I, Lewis, Karl, Lao, Christopher D, Postow, Michael A, Atkins, Michael B, Ernstoff, Marc S, Reardon, David A, Puzanov, Igor, Kudchadkar, Ragini R, Thomas, Reena P, Tarhini, Ahmad, Pavlick, Anna C, Jiang, Joel, Avila, Alexandre, Demelo, Sheena, Margolin, Kim

“…A combination of nivolumab and ipilimumab produced complete responses in 26% and partial responses in 30% of patients with previously untreated brain…”
Get full text

Tuberculosis following PD-1 blockade for cancer immunotherapy by Barber, Daniel L, Sakai, Shunsuke, Kudchadkar, Ragini R, Fling, Steven P, Day, Tracey A, Vergara, Julie A, Ashkin, David, Cheng, Jonathan H, Lundgren, Lisa M, Raabe, Vanessa N, Kraft, Colleen S, Nieva, Jorge J, Cheever, Martin A, Nghiem, Paul T, Sharon, Elad

“…Because of the well-established therapeutic benefit of boosting antitumor responses through blockade of the T cell inhibitory receptor PD-1, it has been…”
Get more information

PICU Up!: Impact of a Quality Improvement Intervention to Promote Early Mobilization in Critically Ill Children by Wieczorek, Beth, Ascenzi, Judith, Kim, Yun, Lenker, Hallie, Potter, Caroline, Shata, Nehal J, Mitchell, Lauren, Haut, Catherine, Berkowitz, Ivor, Pidcock, Frank, Hoch, Jeannine, Malamed, Connie, Kravitz, Tamara, Kudchadkar, Sapna R

“…To determine the safety and feasibility of an early mobilization program in a PICU. Observational, pre-post design. PICU in a tertiary academic hospital in the…”
Get full text

Long‐term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42‐month analysis of the phase II randomized, double‐blind BOLT study by Dummer, R., Guminksi, A., Gutzmer, R., Lear, J.T., Lewis, K.D., Chang, A.L.S., Combemale, P., Dirix, L., Kaatz, M., Kudchadkar, R., Loquai, C., Plummer, R., Schulze, H.‐J., Stratigos, A.J., Trefzer, U., Squittieri, N., Migden, M.R.

“…Summary Background Basal cell carcinomas (BCCs) exhibit aberrant activation of the hedgehog pathway. Sonidegib is a hedgehog pathway inhibitor approved for the…”
Get full text

Effect of anesthetics on microglial activation and nanoparticle uptake: Implications for drug delivery in traumatic brain injury by Kannan, Gokul, Kambhampati, Siva P., Kudchadkar, Sapna R.

“…Traumatic brain injury (TBI) is a serious public health problem, often with devastating consequences for patients and their families. Affordable and timely…”
Get full text

Long‐term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30‐month analysis of the randomized phase 2 BOLT study by Lear, J.T., Migden, M.R., Lewis, K.D., Chang, A.L.S., Guminski, A., Gutzmer, R., Dirix, L., Combemale, P., Stratigos, A., Plummer, R., Castro, H., Yi, T., Mone, M., Zhou, J., Trefzer, U., Kaatz, M., Loquai, C., Kudchadkar, R., Sellami, D., Dummer, R.

“…Background Patients with locally advanced basal cell carcinoma (laBCC) or metastatic BCC (mBCC), two difficult‐to‐treat populations, have had limited treatment…”
Get full text

Sleep of critically ill children in the pediatric intensive care unit: A systematic review by Kudchadkar, Sapna R, Aljohani, Othman A, Punjabi, Naresh M

“…Summary Critically ill children in the pediatric intensive care unit (PICU) are exposed to multiple physical, environmental and pharmacologic factors which…”
Get full text

Mobilization of Mechanically Ventilated Patients in Switzerland by Sibilla, Alberto, Nydahl, Peter, Greco, Nicola, Mungo, Giuseppe, Ott, Natalie, Unger, Ines, Rezek, Spencer, Gemperle, Sarah, Needham, Dale M., Kudchadkar, Sapna R.

“…Purpose: Growing evidence suggests that early mobilization benefits intensive care unit (ICU) patients. However, national practices and the culture of…”
Get full text

Balancing Inflammation: The Link between Th17 and Regulatory T Cells by Lawson, David H., Delman, Keith A., Kudchadkar, Ragini R., Diller, Maggie L., Ford, Mandy L.

“…CD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics…”
Get full text

Rehabilitation in critically ill children: Findings from the Korean National Health Insurance database by Cho, Joongbum, Park, Hyejeong, Kang, Danbee, Park, Esther, Chung, Chi Ryang, Cho, Juhee, Kudchadkar, Sapna R

“…Intensive care unit (ICU) survivors suffer from physical weakness and challenges returning to daily life. With the importance of rehabilitating patients in the…”
Get full text

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling by Kang, Hee-Bum, Fan, Jun, Lin, Ruiting, Elf, Shannon, Ji, Quanjiang, Zhao, Liang, Jin, Lingtao, Seo, Jae Ho, Shan, Changliang, Arbiser, Jack L., Cohen, Cynthia, Brat, Daniel, Miziorko, Henry M., Kim, Eunhee, Abdel-Wahab, Omar, Merghoub, Taha, Fröhling, Stefan, Scholl, Claudia, Tamayo, Pablo, Barbie, David A., Zhou, Lu, Pollack, Brian P., Fisher, Kevin, Kudchadkar, Ragini R., Lawson, David H., Sica, Gabriel, Rossi, Michael, Lonial, Sagar, Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Boggon, Titus J., He, Chuan, Kang, Sumin, Chen, Jing

“…Many human cancers share similar metabolic alterations, including the Warburg effect. However, it remains unclear whether oncogene-specific metabolic…”
Get full text

Comfort and Coordination among Interprofessional Care Providers Involved in Intubations in the Pediatric Intensive Care Unit by Pande, Chetna K., Stayer, Kelsey, Rappold, Thomas, Alvin, Madeleine, Koszela, Keri, Kudchadkar, Sapna R.

“…Background. Successful execution of invasive procedures in acute care settings, including tracheal intubation, requires careful coordination of an…”
Get full text

Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma by Weber, Jeffrey, Mandala, Mario, Del Vecchio, Michele, Gogas, Helen J, Arance, Ana M, Cowey, C. Lance, Dalle, Stéphane, Schenker, Michael, Chiarion-Sileni, Vanna, Marquez-Rodas, Ivan, Grob, Jean-Jacques, Butler, Marcus O, Middleton, Mark R, Maio, Michele, Atkinson, Victoria, Queirolo, Paola, Gonzalez, Rene, Kudchadkar, Ragini R, Smylie, Michael, Meyer, Nicolas, Mortier, Laurent, Atkins, Michael B, Long, Georgina V, Bhatia, Shailender, Lebbé, Celeste, Rutkowski, Piotr, Yokota, Kenji, Yamazaki, Naoya, Kim, Tae M, de Pril, Veerle, Sabater, Javier, Qureshi, Anila, Larkin, James, Ascierto, Paolo A

“…In a randomized trial involving more than 900 patients undergoing resection of advanced melanoma, adjuvant nivolumab was associated with a higher rate of…”
Get full text

Implementation of the ABCDEF Bundle for Critically Ill ICU Patients During the COVID-19 Pandemic: A Multi-National 1-Day Point Prevalence Study by Liu, Keibun, Nakamura, Kensuke, Katsukawa, Hajime, Nydahl, Peter, Ely, Eugene Wesley, Kudchadkar, Sapna R., Takahashi, Kunihiko, Elhadi, Muhammed, Gurjar, Mohan, Leong, Be Kim, Chung, Chi Ryang, Balachandran, Jayachandran, Inoue, Shigeaki, Lefor, Alan Kawarai, Nishida, Osamu

“…Background: Data regarding delivery of evidence-based care to critically ill patients in Intensive Care Units (ICU) during the COVID-19 pandemic is crucial but…”
Get full text

ABCDEF Bundle and Supportive ICU Practices for Patients With Coronavirus Disease 2019 Infection: An International Point Prevalence Study by Liu, Keibun, Nakamura, Kensuke, Katsukawa, Hajime, Elhadi, Muhammed, Nydahl, Peter, Ely, Eugene Wesley, Kudchadkar, Sapna R, Takahashi, Kunihiko, Inoue, Shigeaki, Lefor, Alan Kawarai, Kesecioglu, Jozef, Nishida, Osamu

“…To investigate implementation of evidence-based and supportive cares in ICUs, such as the ABCDEF, nutrition therapy, and ICU diary, for patients with…”
Get full text

Pediatric Critical Care Illness Severity Toolkit: Stata Commands for Calculation of Pediatric Index of Mortality and Pediatric Logistic Organ Dysfunction Scores by Azamfirei, Razvan, Mennie, Colleen, Fackler, James C., Kudchadkar, Sapna R.

“…Abstract Introduction Illness severity scoring tools, such as PRISM III/IV, PIM-3, and PELOD-2, are widely used in pediatric critical care research. However,…”
Get full text

Impact of a multifaceted early mobility intervention for critically ill children - the PICU Up! trial: study protocol for a multicenter stepped-wedge cluster randomized controlled trial by Azamfirei, Razvan, Mennie, Colleen, Dinglas, Victor D, Fatima, Arooj, Colantuoni, Elizabeth, Gurses, Ayse P, Balas, Michele C, Needham, Dale M, Kudchadkar, Sapna R

“…Over 50% of all critically ill children develop preventable intensive care unit-acquired morbidity. Early and progressive mobility is associated with improved…”
Get full text

95 Evaluation of a Simulation Curriculum to Improve Nursing-Led Early Physical Rehabilitation of Critically Ill Children by LaRosa, Jessica M., Lenker, Hallie, Brown, Kristen, Shilkofski, Nicole, Kudchadkar, Sapna R.

“…OBJECTIVES/GOALS: Early pediatric intensive care unit (PICU) mobilization is safe and associated with improved outcomes. Nursing-specific mobility training is…”
Get full text